DegronMD - Q9C0H9(SRCIN1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G524E	TCGA-2F-A9KO	BLCA	TCGA	DSGSSS	DEG_SCF_TRCP1_1	512:517	Mutation rewiring degron network	0.1389
p.E521K	TCGA-BK-A6W3	UCEC	TCGA	DSGSSS	DEG_SCF_TRCP1_1	512:517	Mutation rewiring degron network	0.2222
p.E521K	DO50076	UCEC	ICGC	DSGSSS	DEG_SCF_TRCP1_1	512:517	Mutation rewiring degron network	0.2222
p.P1104L	TCGA-DX-A8BV	SARC	TCGA	VVTPGAS	DEG_SCF_FBW7_1	1101:1107	Mutation altering degron motif	0.7582
p.P1098L	TCGA-IB-7651	PAAD	TCGA	VVTPGAS	DEG_SCF_FBW7_1	1101:1107	Mutation rewiring degron network	0.25
p.A1107V	DO222427	BTCA	ICGC	VVTPGAS	DEG_SCF_FBW7_1	1101:1107	Mutation altering degron motif	0.6936
p.S328L	DO222817	BTCA	ICGC	PPSY	ITCH	337:340	Mutation rewiring degron network	0.0833
p.S339L	DO222955	BTCA	ICGC	PPSY	ITCH	337:340	Mutation altering degron motif	0.6556
p.S1101F	DO10550	COAD	ICGC	VVTPGAS	DEG_SCF_FBW7_1	1101:1107	Mutation altering degron motif	0.7982
p.S341L	DO233759	GACA	ICGC	PPSY	ITCH	337:340	Mutation rewiring degron network	0.3056
p.A333T	DO233782	GACA	ICGC	PPSY	ITCH	337:340	Mutation rewiring degron network	0.2222
p.E1113K	DO49069	HNSC	ICGC	VVTPGAS	DEG_SCF_FBW7_1	1101:1107	Mutation rewiring degron network	0.1667
p.S1094F	DO231942	LICA	ICGC	VVTPGAS	DEG_SCF_FBW7_1	1101:1107	Mutation rewiring degron network	0.1389
p.E350K	DO26280	LUAD	ICGC	PPSY	ITCH	337:340	Mutation rewiring degron network	0.0556
p.R1108W	DO222363	MELA	ICGC	VVTPGAS	DEG_SCF_FBW7_1	1101:1107	Mutation rewiring degron network	0.3056
p.A1097V	DO222702	MELA	ICGC	VVTPGAS	DEG_SCF_FBW7_1	1101:1107	Mutation rewiring degron network	0.2222
p.R327H	DO229253	THCA	ICGC	PPSY	ITCH	337:340	Mutation rewiring degron network	0.0556
p.D1114Y	DO41361	UCEC	ICGC	VVTPGAS	DEG_SCF_FBW7_1	1101:1107	Mutation rewiring degron network	0.1389
p.R336H	SIDM01314	Colorectal Carcinoma	GDSC	PPSY	ITCH	337:340	Mutation rewiring degron network	0.3056
p.G1093R	SIDM01612	Endometrial Carcinoma	GDSC	VVTPGAS	DEG_SCF_FBW7_1	1101:1107	Mutation rewiring degron network	0.1111
p.A1111V	ACH-000659	Lung Cancer	CCLE	VVTPGAS	DEG_SCF_FBW7_1	1101:1107	Mutation rewiring degron network	0.2222
p.A1111V	ACH-001386	Lung Cancer	CCLE	VVTPGAS	DEG_SCF_FBW7_1	1101:1107	Mutation rewiring degron network	0.2222

Kaplan plot for SRCIN1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SRCIN1

UniProt ID: Q9C0H9

Entrez ID: 80725

Protein name: SRC kinase signaling inhibitor 1 (SNAP-25-interacting protein) (SNIP) (p130Cas-associated protein) (p140Cap)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SRCIN1 in