DegronMD

Uniprot ID: Q9C0H9

Source protein: SRC kinase signaling inhibitor 1

Source gene: SRCIN1

Class: DEG_SCF_FBW7_1

Location: 1101:1107

E3 ligase: FBXW7

DEGRON score: 0.9824

ASA_SCORE: 73.9

COIL: 0.8661

CONS_SCORE: 0

DSS_SCORE: 0.6088

HELIX: 0.0837

FCONS_SCORE: 0

RIG_SCORE: 0.701

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1104L	TCGA-DX-A8BV	SARC	TCGA	VVTPGAS	DEG_SCF_FBW7_1	0.7582
p.P1098L	TCGA-IB-7651	PAAD	TCGA	VVTPGAS	DEG_SCF_FBW7_1	0.25
p.A1107V	DO222427	BTCA	ICGC	VVTPGAS	DEG_SCF_FBW7_1	0.6936
p.S1101F	DO10550	COAD	ICGC	VVTPGAS	DEG_SCF_FBW7_1	0.7982
p.E1113K	DO49069	HNSC	ICGC	VVTPGAS	DEG_SCF_FBW7_1	0.1667
p.S1094F	DO231942	LICA	ICGC	VVTPGAS	DEG_SCF_FBW7_1	0.1389
p.R1108W	DO222363	MELA	ICGC	VVTPGAS	DEG_SCF_FBW7_1	0.3056
p.A1097V	DO222702	MELA	ICGC	VVTPGAS	DEG_SCF_FBW7_1	0.2222
p.D1114Y	DO41361	UCEC	ICGC	VVTPGAS	DEG_SCF_FBW7_1	0.1389
p.G1093R	SIDM01612	Endometrial Carcinoma	GDSC	VVTPGAS	DEG_SCF_FBW7_1	0.1111
p.A1111V	ACH-000659	Lung Cancer	CCLE	VVTPGAS	DEG_SCF_FBW7_1	0.2222
p.A1111V	ACH-001386	Lung Cancer	CCLE	VVTPGAS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0H9	SRC kinase signaling inhibitor 1	DEG_SCF_FBW7_1	1101:1107	VVTPGAS	FBXW7	0.9824	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons