DegronMD

Uniprot ID: Q9C0H9

Source protein: SRC kinase signaling inhibitor 1

Source gene: SRCIN1

Class: DEG_SCF_TRCP1_1

Location: 512:517

E3 ligase: BTRC

DEGRON score: 0.9672

ASA_SCORE: 66.65

COIL: 0.907

CONS_SCORE: 0.4707

DSS_SCORE: 0.6801

HELIX: 0.0435

FCONS_SCORE: 1.0103

RIG_SCORE: 0.5739

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G524E	TCGA-2F-A9KO	BLCA	TCGA	DSGSSS	DEG_SCF_TRCP1_1	0.1389
p.E521K	TCGA-BK-A6W3	UCEC	TCGA	DSGSSS	DEG_SCF_TRCP1_1	0.2222
p.E521K	DO50076	UCEC	ICGC	DSGSSS	DEG_SCF_TRCP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13428	Treacle protein	DEG_SCF_TRCP1_1	931:936	DSGSSS	BTRC	0.9956	More...
Q8IYG6	Leucine-rich repeat-containing protein 56	DEG_SCF_TRCP1_1	460:465	DSGSSS	BTRC	0.9835	More...
Q96S38	Ribosomal protein S6 kinase delta-1	DEG_SCF_TRCP1_1	499:504	DSGSSS	BTRC	0.9876	More...
Q9C0H9	SRC kinase signaling inhibitor 1	DEG_SCF_TRCP1_1	512:517	DSGSSS	BTRC	0.9672	More...
Q9H7S9	Zinc finger protein 703	DEG_SCF_TRCP1_1	169:174	DSGSSS	BTRC	0.9995	More...
Q9NQ76	Matrix extracellular phosphoglycoprotein	DEG_SCF_TRCP1_1	515:520	DSGSSS	BTRC	0.9943	More...
Q9Y4G8	Rap guanine nucleotide exchange factor 2	DEG_SCF_TRCP1_1	53:58	DSGSSS	BTRC	0.9394	More...
Q9C0H5	Rho GTPase-activating protein 39	DEG_SCF_TRCP1_1	168:173	DSGSSS	BTRC	0.9988	More...
Q86VQ1	Glucocorticoid-induced transcript 1 protein	DEG_SCF_TRCP1_1	393:398	DSGSSS	BTRC	0.9577	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons