DegronMD - Q8IYG6(LRRC56)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D372N	TCGA-36-2534	OV	TCGA	AASTS	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.1944
p.D372N	DO29046	OV	ICGC	AASTS	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.1944
p.D372Y	TCGA-64-1676	LUAD	TCGA	AASTS	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.1944
p.D372Y	DO23629	LUAD	ICGC	AASTS	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.1944
p.P355S	TCGA-AJ-A3OJ	UCEC	TCGA	AASTS	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.1111
p.P355S	TCGA-B5-A1MX	UCEC	TCGA	AASTS	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.1111
p.P355S	DO41999	UCEC	ICGC	AASTS	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.1111
p.P355S	DO42753	UCEC	ICGC	AASTS	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.1111
p.D471G	TCGA-BR-8680	STAD	TCGA	DSGSSS	DEG_SCF_TRCP1_1	460:465	Mutation rewiring degron network	0.1667
p.D471G	TCGA-BR-8680	STAD	TCGA	LQSRGRRLR	SCF_FBXL2	472:480	Mutation rewiring degron network	0.3056
p.D471G	DO47769	STAD	ICGC	DSGSSS	DEG_SCF_TRCP1_1	460:465	Mutation rewiring degron network	0.1667
p.D471G	DO47769	STAD	ICGC	LQSRGRRLR	SCF_FBXL2	472:480	Mutation rewiring degron network	0.3056
p.Q353L	TCGA-CC-A7IK	LIHC	TCGA	AASTS	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.0556
p.Q353L	DO52184	LIHC	ICGC	AASTS	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.0556
p.Q473K	TCGA-CR-7367	HNSC	TCGA	LQSRGRRLR	SCF_FBXL2	472:480	Mutation altering degron motif	0.6944
p.Q473K	DO15999	HNSC	ICGC	LQSRGRRLR	SCF_FBXL2	472:480	Mutation altering degron motif	0.6944
p.P369T	TCGA-D3-A1Q6	SKCM	TCGA	AASTS	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.2778
p.P369T	DO37450	SKCM	ICGC	AASTS	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.2778
p.P466L	TCGA-D3-A2JL	SKCM	TCGA	DSGSSS	DEG_SCF_TRCP1_1	460:465	Mutation rewiring degron network	0.3056
p.P466L	TCGA-D3-A2JL	SKCM	TCGA	LQSRGRRLR	SCF_FBXL2	472:480	Mutation rewiring degron network	0.1667
p.P466L	DO47278	SKCM	ICGC	DSGSSS	DEG_SCF_TRCP1_1	460:465	Mutation rewiring degron network	0.3056
p.P466L	DO47278	SKCM	ICGC	LQSRGRRLR	SCF_FBXL2	472:480	Mutation rewiring degron network	0.1667
p.R480L	TCGA-EE-A2MK	SKCM	TCGA	LQSRGRRLR	SCF_FBXL2	472:480	Mutation altering degron motif	0.7316
p.R480L	DO38177	SKCM	ICGC	LQSRGRRLR	SCF_FBXL2	472:480	Mutation altering degron motif	0.7316
p.L354V	TCGA-EL-A3D0	THCA	TCGA	AASTS	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.0833
p.L354V	DO48127	THCA	ICGC	AASTS	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.0833
p.K454E	TCGA-EO-A22X	UCEC	TCGA	DSGSSS	DEG_SCF_TRCP1_1	460:465	Mutation substituting flanking lysine	0.2778
p.K454E	DO43907	UCEC	ICGC	DSGSSS	DEG_SCF_TRCP1_1	460:465	Mutation substituting flanking lysine	0.2778
p.Q473E	TCGA-FI-A3PX	UCEC	TCGA	LQSRGRRLR	SCF_FBXL2	472:480	Mutation altering degron motif	0.6744
p.Q473E	DO52417	UCEC	ICGC	LQSRGRRLR	SCF_FBXL2	472:480	Mutation altering degron motif	0.6744
p.R477C	TCGA-HU-A4GU	STAD	TCGA	LQSRGRRLR	SCF_FBXL2	472:480	Mutation altering degron motif	0.719
p.R477C	DO47849	STAD	ICGC	LQSRGRRLR	SCF_FBXL2	472:480	Mutation altering degron motif	0.719
p.R477C	SIDM02015	Colorectal Carcinoma	GDSC	LQSRGRRLR	SCF_FBXL2	472:480	Mutation altering degron motif	0.719
p.S441F	TCGA-XF-A9SX	BLCA	TCGA	TSSQHLVPSP	DEG_COP1_1	443:452	Mutation rewiring degron network	0.2778
p.S441F	DO51916	BLCA	ICGC	TSSQHLVPSP	DEG_COP1_1	443:452	Mutation rewiring degron network	0.2778
p.S464N	DO222427	BTCA	ICGC	DSGSSS	DEG_SCF_TRCP1_1	460:465	Mutation altering degron motif	0.7069
p.GT442GP	DO222558	COCA	ICGC	TSSQHLVPSP	DEG_COP1_1	443:452	Mutation rewiring degron network	0
p.T368I	DO48328	ESCA	ICGC	AASTS	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.3056
p.P362L	DO233089	GACA	ICGC	AASTS	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.3056
p.R467Q	DO229480	LAML	ICGC	DSGSSS	DEG_SCF_TRCP1_1	460:465	Mutation rewiring degron network	0.2778
p.R467Q	DO229480	LAML	ICGC	LQSRGRRLR	SCF_FBXL2	472:480	Mutation rewiring degron network	0.1944
p.R467Q	DO230993	LUSC	ICGC	DSGSSS	DEG_SCF_TRCP1_1	460:465	Mutation rewiring degron network	0.2778
p.R467Q	DO230993	LUSC	ICGC	LQSRGRRLR	SCF_FBXL2	472:480	Mutation rewiring degron network	0.1944
p.S445R	DO232829	NACA	ICGC	TSSQHLVPSP	DEG_COP1_1	443:452	Mutation altering degron motif	0.7427
p.G442R	SIDM01110	Hepatocellular Carcinoma	GDSC	TSSQHLVPSP	DEG_COP1_1	443:452	Mutation rewiring degron network	0.3056
p.R459P	SIDM00983	Bladder Carcinoma	GDSC	TSSQHLVPSP	DEG_COP1_1	443:452	Mutation rewiring degron network	0.1389
p.R459P	SIDM00983	Bladder Carcinoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	460:465	Mutation rewiring degron network	0.3056
p.R459P	ACH-000896	Bladder Cancer	CCLE	TSSQHLVPSP	DEG_COP1_1	443:452	Mutation rewiring degron network	0.1389
p.R459P	ACH-000896	Bladder Cancer	CCLE	DSGSSS	DEG_SCF_TRCP1_1	460:465	Mutation rewiring degron network	0.3056
p.R459P	647-V	urinary tract	COSMIC	TSSQHLVPSP	DEG_COP1_1	443:452	Mutation rewiring degron network	0.1389
p.R459P	647-V	urinary tract	COSMIC	DSGSSS	DEG_SCF_TRCP1_1	460:465	Mutation rewiring degron network	0.3056
p.R467W	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	460:465	Mutation rewiring degron network	0.2778
p.R467W	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	LQSRGRRLR	SCF_FBXL2	472:480	Mutation rewiring degron network	0.1944
p.R467W	ACH-000980	Lung Cancer	CCLE	DSGSSS	DEG_SCF_TRCP1_1	460:465	Mutation rewiring degron network	0.2778
p.R467W	ACH-000980	Lung Cancer	CCLE	LQSRGRRLR	SCF_FBXL2	472:480	Mutation rewiring degron network	0.1944
p.R467W	NCI-H1155	lung	COSMIC	DSGSSS	DEG_SCF_TRCP1_1	460:465	Mutation rewiring degron network	0.2778
p.R467W	NCI-H1155	lung	COSMIC	LQSRGRRLR	SCF_FBXL2	472:480	Mutation rewiring degron network	0.1944
p.W485L	SIDM01617	Endometrial Carcinoma	GDSC	LQSRGRRLR	SCF_FBXL2	472:480	Mutation rewiring degron network	0.1944
p.W485L	ACH-000994	Endometrial/Uterine Cancer	CCLE	LQSRGRRLR	SCF_FBXL2	472:480	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LRRC56

UniProt ID: Q8IYG6

Entrez ID: 115399

Protein name: Leucine-rich repeat-containing protein 56

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LRRC56 in