DegronMD - Q8IYG6(LRRC56)

FUNCTION: Required for the assembly of dynein arms. {ECO:0000250|UniProtKB:Q387Y5}.

GO - Biological processes (BP): cell projection organization [GO:0030030]

GO - Molecular function (MF):

GO - Cellular component (CC): cilium [GO:0005929]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
TSSQHLVPSP	DEG_COP1_1	COP1	Leucine-rich repeat-containing protein 56	443:452	More..
DSGSSS	DEG_SCF_TRCP1_1	BTRC	Leucine-rich repeat-containing protein 56	460:465	More..
AASTS	DEG_SPOP_SBC_1	SPOP	Leucine-rich repeat-containing protein 56	363:367	More..
LQSRGRRLR	SCF_FBXL2	FBXL2	Leucine-rich repeat-containing protein 56	472:480	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S445R	DO232829	NACA	ICGC	TSSQHLVPSP	DEG_COP1_1	443:452	Mutation altering degron motif	0.7427
p.R480L	TCGA-EE-A2MK	SKCM	TCGA	LQSRGRRLR	SCF_FBXL2	472:480	Mutation altering degron motif	0.7316
p.R480L	DO38177	SKCM	ICGC	LQSRGRRLR	SCF_FBXL2	472:480	Mutation altering degron motif	0.7316
p.R477C	TCGA-HU-A4GU	STAD	TCGA	LQSRGRRLR	SCF_FBXL2	472:480	Mutation altering degron motif	0.719
p.R477C	DO47849	STAD	ICGC	LQSRGRRLR	SCF_FBXL2	472:480	Mutation altering degron motif	0.719
p.R477C	SIDM02015	Colorectal Carcinoma	GDSC	LQSRGRRLR	SCF_FBXL2	472:480	Mutation altering degron motif	0.719
p.S464N	DO222427	BTCA	ICGC	DSGSSS	DEG_SCF_TRCP1_1	460:465	Mutation altering degron motif	0.7069
p.Q473K	TCGA-CR-7367	HNSC	TCGA	LQSRGRRLR	SCF_FBXL2	472:480	Mutation altering degron motif	0.6944
p.Q473K	DO15999	HNSC	ICGC	LQSRGRRLR	SCF_FBXL2	472:480	Mutation altering degron motif	0.6944
p.Q473E	TCGA-FI-A3PX	UCEC	TCGA	LQSRGRRLR	SCF_FBXL2	472:480	Mutation altering degron motif	0.6744
p.Q473E	DO52417	UCEC	ICGC	LQSRGRRLR	SCF_FBXL2	472:480	Mutation altering degron motif	0.6744
p.D471G	TCGA-BR-8680	STAD	TCGA	LQSRGRRLR	SCF_FBXL2	472:480	Mutation rewiring degron network	0.3056
p.D471G	DO47769	STAD	ICGC	LQSRGRRLR	SCF_FBXL2	472:480	Mutation rewiring degron network	0.3056
p.P466L	TCGA-D3-A2JL	SKCM	TCGA	DSGSSS	DEG_SCF_TRCP1_1	460:465	Mutation rewiring degron network	0.3056
p.P466L	DO47278	SKCM	ICGC	DSGSSS	DEG_SCF_TRCP1_1	460:465	Mutation rewiring degron network	0.3056
p.T368I	DO48328	ESCA	ICGC	AASTS	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.3056
p.P362L	DO233089	GACA	ICGC	AASTS	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.3056
p.G442R	SIDM01110	Hepatocellular Carcinoma	GDSC	TSSQHLVPSP	DEG_COP1_1	443:452	Mutation rewiring degron network	0.3056
p.R459P	SIDM00983	Bladder Carcinoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	460:465	Mutation rewiring degron network	0.3056
p.R459P	ACH-000896	Bladder Cancer	CCLE	DSGSSS	DEG_SCF_TRCP1_1	460:465	Mutation rewiring degron network	0.3056

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Kaplan plot for LRRC56 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LRRC56

UniProt ID: Q8IYG6

Entrez ID: 115399

Protein name: Leucine-rich repeat-containing protein 56

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LRRC56 in