DegronMD

Uniprot ID: Q8IYG6

Source protein: Leucine-rich repeat-containing protein 56

Source gene: LRRC56

Class: DEG_COP1_1

Location: 443:452

E3 ligase: COP1

DEGRON score: 0.9136

ASA_SCORE: 87.38

COIL: 0.8894

CONS_SCORE: 0.3175

DSS_SCORE: 0.853

HELIX: 0.0768

FCONS_SCORE: 1.0091

RIG_SCORE: 0.4951

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S441F	TCGA-XF-A9SX	BLCA	TCGA	TSSQHLVPSP	DEG_COP1_1	0.2778
p.S441F	DO51916	BLCA	ICGC	TSSQHLVPSP	DEG_COP1_1	0.2778
p.GT442GP	DO222558	COCA	ICGC	TSSQHLVPSP	DEG_COP1_1	0
p.S445R	DO232829	NACA	ICGC	TSSQHLVPSP	DEG_COP1_1	0.7427
p.G442R	SIDM01110	Hepatocellular Carcinoma	GDSC	TSSQHLVPSP	DEG_COP1_1	0.3056
p.R459P	SIDM00983	Bladder Carcinoma	GDSC	TSSQHLVPSP	DEG_COP1_1	0.1389
p.R459P	ACH-000896	Bladder Cancer	CCLE	TSSQHLVPSP	DEG_COP1_1	0.1389
p.R459P	647-V	urinary_tract	COSMIC	TSSQHLVPSP	DEG_COP1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IYG6	Leucine-rich repeat-containing protein 56	DEG_COP1_1	443:452	TSSQHLVPSP	COP1	0.9136	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons