DegronMD

Uniprot ID: Q8IYG6

Source protein: Leucine-rich repeat-containing protein 56

Source gene: LRRC56

Class: DEG_SCF_TRCP1_1

Location: 460:465

E3 ligase: BTRC

DEGRON score: 0.9835

ASA_SCORE: 77.7833

COIL: 0.956

CONS_SCORE: 0.2666

DSS_SCORE: 0.7638

HELIX: 0.0323

FCONS_SCORE: 0.8359

RIG_SCORE: 0.4916

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D471G	TCGA-BR-8680	STAD	TCGA	DSGSSS	DEG_SCF_TRCP1_1	0.1667
p.D471G	DO47769	STAD	ICGC	DSGSSS	DEG_SCF_TRCP1_1	0.1667
p.P466L	TCGA-D3-A2JL	SKCM	TCGA	DSGSSS	DEG_SCF_TRCP1_1	0.3056
p.P466L	DO47278	SKCM	ICGC	DSGSSS	DEG_SCF_TRCP1_1	0.3056
p.K454E	TCGA-EO-A22X	UCEC	TCGA	DSGSSS	DEG_SCF_TRCP1_1	0.2778
p.K454E	DO43907	UCEC	ICGC	DSGSSS	DEG_SCF_TRCP1_1	0.2778
p.S464N	DO222427	BTCA	ICGC	DSGSSS	DEG_SCF_TRCP1_1	0.7069
p.R467Q	DO229480	LAML	ICGC	DSGSSS	DEG_SCF_TRCP1_1	0.2778
p.R467Q	DO230993	LUSC	ICGC	DSGSSS	DEG_SCF_TRCP1_1	0.2778
p.R459P	SIDM00983	Bladder Carcinoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	0.3056
p.R459P	ACH-000896	Bladder Cancer	CCLE	DSGSSS	DEG_SCF_TRCP1_1	0.3056
p.R459P	647-V	urinary_tract	COSMIC	DSGSSS	DEG_SCF_TRCP1_1	0.3056
p.R467W	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	0.2778
p.R467W	ACH-000980	Lung Cancer	CCLE	DSGSSS	DEG_SCF_TRCP1_1	0.2778
p.R467W	NCI-H1155	lung	COSMIC	DSGSSS	DEG_SCF_TRCP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13428	Treacle protein	DEG_SCF_TRCP1_1	931:936	DSGSSS	BTRC	0.9956	More...
Q8IYG6	Leucine-rich repeat-containing protein 56	DEG_SCF_TRCP1_1	460:465	DSGSSS	BTRC	0.9835	More...
Q96S38	Ribosomal protein S6 kinase delta-1	DEG_SCF_TRCP1_1	499:504	DSGSSS	BTRC	0.9876	More...
Q9C0H9	SRC kinase signaling inhibitor 1	DEG_SCF_TRCP1_1	512:517	DSGSSS	BTRC	0.9672	More...
Q9H7S9	Zinc finger protein 703	DEG_SCF_TRCP1_1	169:174	DSGSSS	BTRC	0.9995	More...
Q9NQ76	Matrix extracellular phosphoglycoprotein	DEG_SCF_TRCP1_1	515:520	DSGSSS	BTRC	0.9943	More...
Q9Y4G8	Rap guanine nucleotide exchange factor 2	DEG_SCF_TRCP1_1	53:58	DSGSSS	BTRC	0.9394	More...
Q9C0H5	Rho GTPase-activating protein 39	DEG_SCF_TRCP1_1	168:173	DSGSSS	BTRC	0.9988	More...
Q86VQ1	Glucocorticoid-induced transcript 1 protein	DEG_SCF_TRCP1_1	393:398	DSGSSS	BTRC	0.9577	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons