DegronMD - Q9NQ76(MEPE)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A160S	TCGA-38-4631	LUAD	TCGA	NKENT	DEG_APCC_KENBOX_2	168:172	Mutation rewiring degron network	0.1111
p.Y186H	TCGA-43-2578	LUSC	TCGA	PRNVLNIIP	DEG_APCC_DBOX_1	173:181	Mutation rewiring degron network	0.1944
p.S510I	TCGA-49-4488	LUAD	TCGA	DSGSSS	DEG_SCF_TRCP1_1	515:520	Mutation rewiring degron network	0.1944
p.S510I	DO24750	LUAD	ICGC	DSGSSS	DEG_SCF_TRCP1_1	515:520	Mutation rewiring degron network	0.1944
p.G111C	TCGA-50-5049	LUAD	TCGA	NKENT	DEG_APCC_KENBOX_2	104:108	Mutation rewiring degron network	0.25
p.G111C	DO229022	LICA	ICGC	NKENT	DEG_APCC_KENBOX_2	104:108	Mutation rewiring degron network	0.25
p.G111C	DO23705	LUAD	ICGC	NKENT	DEG_APCC_KENBOX_2	104:108	Mutation rewiring degron network	0.25
p.T108S	TCGA-50-6593	LUAD	TCGA	NKENT	DEG_APCC_KENBOX_2	104:108	Mutation altering degron motif	0.6005
p.T108S	DO24100	LUAD	ICGC	NKENT	DEG_APCC_KENBOX_2	104:108	Mutation altering degron motif	0.6005
p.L164M	TCGA-99-8028	LUAD	TCGA	PRNVLNIIP	DEG_APCC_DBOX_1	173:181	Mutation rewiring degron network	0.0833
p.L164M	TCGA-99-8028	LUAD	TCGA	NKENT	DEG_APCC_KENBOX_2	168:172	Mutation rewiring degron network	0.2222
p.L164M	SNU-175	large intestine	COSMIC	PRNVLNIIP	DEG_APCC_DBOX_1	173:181	Mutation rewiring degron network	0.0833
p.L164M	SNU-175	large intestine	COSMIC	NKENT	DEG_APCC_KENBOX_2	168:172	Mutation rewiring degron network	0.2222
p.E106D	TCGA-A5-A2K5	UCEC	TCGA	NKENT	DEG_APCC_KENBOX_2	104:108	Mutation altering degron motif	0.6758
p.E106D	TCGA-BS-A0UV	UCEC	TCGA	NKENT	DEG_APCC_KENBOX_2	104:108	Mutation altering degron motif	0.6758
p.N178S	TCGA-A5-A2K5	UCEC	TCGA	PRNVLNIIP	DEG_APCC_DBOX_1	173:181	Mutation altering degron motif	0.5958
p.N178S	DO41379	UCEC	ICGC	PRNVLNIIP	DEG_APCC_DBOX_1	173:181	Mutation altering degron motif	0.5958
p.D509G	TCGA-A6-5665	COAD	TCGA	DSGSSS	DEG_SCF_TRCP1_1	515:520	Mutation rewiring degron network	0.1667
p.L96M	TCGA-AP-A051	UCEC	TCGA	NKENT	DEG_APCC_KENBOX_2	104:108	Mutation rewiring degron network	0.1111
p.L96M	DO42673	UCEC	ICGC	NKENT	DEG_APCC_KENBOX_2	104:108	Mutation rewiring degron network	0.1111
p.I161V	TCGA-AX-A06F	UCEC	TCGA	NKENT	DEG_APCC_KENBOX_2	168:172	Mutation rewiring degron network	0.1389
p.I161V	DO41752	UCEC	ICGC	NKENT	DEG_APCC_KENBOX_2	168:172	Mutation rewiring degron network	0.1389
p.S191L	TCGA-AZ-4315	COAD	TCGA	PRNVLNIIP	DEG_APCC_DBOX_1	173:181	Mutation rewiring degron network	0.0556
p.R505C	TCGA-B5-A11H	UCEC	TCGA	DSGSSS	DEG_SCF_TRCP1_1	515:520	Mutation rewiring degron network	0.0556
p.R53I	TCGA-BK-A6W3	UCEC	TCGA	SKENI	DEG_APCC_KENBOX_2	60:64	Mutation rewiring degron network	0.1389
p.H190Q	TCGA-D1-A0ZO	UCEC	TCGA	PRNVLNIIP	DEG_APCC_DBOX_1	173:181	Mutation rewiring degron network	0.0833
p.P118H	TCGA-D3-A2JC	SKCM	TCGA	NKENT	DEG_APCC_KENBOX_2	104:108	Mutation rewiring degron network	0.0556
p.S73F	TCGA-D3-A2JO	SKCM	TCGA	SKENI	DEG_APCC_KENBOX_2	60:64	Mutation rewiring degron network	0.0833
p.A160V	TCGA-DF-A2KV	UCEC	TCGA	NKENT	DEG_APCC_KENBOX_2	168:172	Mutation rewiring degron network	0.1111
p.A160V	TCGA-QS-A5YQ	UCEC	TCGA	NKENT	DEG_APCC_KENBOX_2	168:172	Mutation rewiring degron network	0.1111
p.A160V	DO222884	COCA	ICGC	NKENT	DEG_APCC_KENBOX_2	168:172	Mutation rewiring degron network	0.1111
p.A160V	DO228544	GACA	ICGC	NKENT	DEG_APCC_KENBOX_2	168:172	Mutation rewiring degron network	0.1111
p.A160V	DO219771	UCEC	ICGC	NKENT	DEG_APCC_KENBOX_2	168:172	Mutation rewiring degron network	0.1111
p.A160V	DO49073	UCEC	ICGC	NKENT	DEG_APCC_KENBOX_2	168:172	Mutation rewiring degron network	0.1111
p.S73P	TCGA-DU-6392	LGG	TCGA	SKENI	DEG_APCC_KENBOX_2	60:64	Mutation rewiring degron network	0.0833
p.V65A	TCGA-FV-A496	LIHC	TCGA	SKENI	DEG_APCC_KENBOX_2	60:64	Mutation rewiring degron network	0.3056
p.S101I	TCGA-NC-A5HD	LUSC	TCGA	NKENT	DEG_APCC_KENBOX_2	104:108	Mutation rewiring degron network	0.25
p.S101I	DO219184	LUSC	ICGC	NKENT	DEG_APCC_KENBOX_2	104:108	Mutation rewiring degron network	0.25
p.E166K	TCGA-RP-A694	SKCM	TCGA	PRNVLNIIP	DEG_APCC_DBOX_1	173:181	Mutation rewiring degron network	0.1389
p.E166K	TCGA-RP-A694	SKCM	TCGA	NKENT	DEG_APCC_KENBOX_2	168:172	Mutation rewiring degron network	0.2778
p.E166K	DO51269	SKCM	ICGC	PRNVLNIIP	DEG_APCC_DBOX_1	173:181	Mutation rewiring degron network	0.1389
p.E166K	DO51269	SKCM	ICGC	NKENT	DEG_APCC_KENBOX_2	168:172	Mutation rewiring degron network	0.2778
p.E167K	TCGA-UF-A7JA	HNSC	TCGA	PRNVLNIIP	DEG_APCC_DBOX_1	173:181	Mutation rewiring degron network	0.1667
p.E167K	TCGA-UF-A7JA	HNSC	TCGA	NKENT	DEG_APCC_KENBOX_2	168:172	Mutation rewiring degron network	0.3056
p.E166D	TCGA-VQ-A91S	STAD	TCGA	PRNVLNIIP	DEG_APCC_DBOX_1	173:181	Mutation rewiring degron network	0.1389
p.E166D	TCGA-VQ-A91S	STAD	TCGA	NKENT	DEG_APCC_KENBOX_2	168:172	Mutation rewiring degron network	0.2778
p.I179L	TCGA-YD-A89C	SKCM	TCGA	PRNVLNIIP	DEG_APCC_DBOX_1	173:181	Mutation altering degron motif	0.6063
p.I179L	DO219501	SKCM	ICGC	PRNVLNIIP	DEG_APCC_DBOX_1	173:181	Mutation altering degron motif	0.6063
p.E99K	DO10172	COAD	ICGC	NKENT	DEG_APCC_KENBOX_2	104:108	Mutation rewiring degron network	0.1944
p.K171T	DO7801	COAD	ICGC	NKENT	DEG_APCC_KENBOX_2	168:172	Mutation altering degron motif	0.7306
p.S167L	DO8842	COAD	ICGC	PRNVLNIIP	DEG_APCC_DBOX_1	173:181	Mutation rewiring degron network	0.1667
p.S167L	DO8842	COAD	ICGC	NKENT	DEG_APCC_KENBOX_2	168:172	Mutation rewiring degron network	0.3056
p.R191C	DO233265	GACA	ICGC	PRNVLNIIP	DEG_APCC_DBOX_1	173:181	Mutation rewiring degron network	0.0556
p.Q56H	DO233950	GACA	ICGC	SKENI	DEG_APCC_KENBOX_2	60:64	Mutation rewiring degron network	0.2222
p.S520I	DO229018	LICA	ICGC	DSGSSS	DEG_SCF_TRCP1_1	515:520	Mutation altering degron motif	0.8453
p.S520I	DO229028	LICA	ICGC	DSGSSS	DEG_SCF_TRCP1_1	515:520	Mutation altering degron motif	0.8453
p.V50F	DO229015	LICA	ICGC	SKENI	DEG_APCC_KENBOX_2	60:64	Mutation rewiring degron network	0.0556
p.A158S	DO229029	LICA	ICGC	NKENT	DEG_APCC_KENBOX_2	168:172	Mutation rewiring degron network	0.0556
p.E167G	DO229237	LMS	ICGC	PRNVLNIIP	DEG_APCC_DBOX_1	173:181	Mutation rewiring degron network	0.1667
p.E167G	DO229237	LMS	ICGC	NKENT	DEG_APCC_KENBOX_2	168:172	Mutation rewiring degron network	0.3056
p.S182R	DO230968	LUSC	ICGC	PRNVLNIIP	DEG_APCC_DBOX_1	173:181	Mutation rewiring degron network	0.3056
p.S182R	DO230968	LUSC	ICGC	NKENT	DEG_APCC_KENBOX_2	168:172	Mutation rewiring degron network	0.0556
p.S182R	DO224621	LUSC	ICGC	PRNVLNIIP	DEG_APCC_DBOX_1	173:181	Mutation rewiring degron network	0.3056
p.S182R	DO224621	LUSC	ICGC	NKENT	DEG_APCC_KENBOX_2	168:172	Mutation rewiring degron network	0.0556
p.Y162H	DO26662	LUSC	ICGC	NKENT	DEG_APCC_KENBOX_2	168:172	Mutation substituting flanking lysine	0.2778
p.S60P	DO222420	MELA	ICGC	SKENI	DEG_APCC_KENBOX_2	60:64	Mutation altering degron motif	0.5641
p.D169N	DO222743	MELA	ICGC	NKENT	DEG_APCC_KENBOX_2	168:172	Mutation altering degron motif	0.6932
p.N107I	DO222843	MELA	ICGC	NKENT	DEG_APCC_KENBOX_2	104:108	Mutation altering degron motif	0.728
p.L51R	DO36556	READ	ICGC	SKENI	DEG_APCC_KENBOX_2	60:64	Mutation rewiring degron network	0.0833
p.K100R	DO36619	READ	ICGC	NKENT	DEG_APCC_KENBOX_2	104:108	Mutation rewiring degron network	0.2222
p.R175K	DO47389	SKCM	ICGC	PRNVLNIIP	DEG_APCC_DBOX_1	173:181	Mutation altering degron motif	0.7237
p.P94H	DO47578	SKCM	ICGC	NKENT	DEG_APCC_KENBOX_2	104:108	Mutation rewiring degron network	0.0556
p.T97I	DO38111	SKCM	ICGC	NKENT	DEG_APCC_KENBOX_2	104:108	Mutation rewiring degron network	0.1389
p.D107N	DO51298	SKCM	ICGC	NKENT	DEG_APCC_KENBOX_2	104:108	Mutation altering degron motif	0.6932
p.F102V	DO42280	UCEC	ICGC	NKENT	DEG_APCC_KENBOX_2	104:108	Mutation rewiring degron network	0.2778
p.H166Q	DO41927	UCEC	ICGC	PRNVLNIIP	DEG_APCC_DBOX_1	173:181	Mutation rewiring degron network	0.1389
p.H166Q	DO41927	UCEC	ICGC	NKENT	DEG_APCC_KENBOX_2	168:172	Mutation rewiring degron network	0.2778
p.R99S	SIDM00401	Melanoma	GDSC	NKENT	DEG_APCC_KENBOX_2	104:108	Mutation rewiring degron network	0.1944
p.R99S	RVH-421	skin	COSMIC	NKENT	DEG_APCC_KENBOX_2	104:108	Mutation rewiring degron network	0.1944
p.G521V	SIDM00390	T-Cell Non-Hodgkin's Lymphoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	515:520	Mutation rewiring degron network	0.3056
p.G521V	SU-DHL-1	haematopoietic and lymphoid tissue	COSMIC	DSGSSS	DEG_SCF_TRCP1_1	515:520	Mutation rewiring degron network	0.3056
p.P58R	SIDM00454	Rhabdomyosarcoma	GDSC	SKENI	DEG_APCC_KENBOX_2	60:64	Mutation rewiring degron network	0.2778
p.G113R	SIDM01175	Other Sarcomas	GDSC	NKENT	DEG_APCC_KENBOX_2	104:108	Mutation rewiring degron network	0.1944
p.G113R	SW684	soft tissue	COSMIC	NKENT	DEG_APCC_KENBOX_2	104:108	Mutation rewiring degron network	0.1944
p.R512W	SIDM00656	Burkitt's Lymphoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	515:520	Mutation rewiring degron network	0.25
p.R512W	SIDM00633	Breast Carcinoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	515:520	Mutation rewiring degron network	0.25
p.R512W	SIDM00660	Colorectal Carcinoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	515:520	Mutation rewiring degron network	0.25
p.R512W	SIDM00032	Bladder Carcinoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	515:520	Mutation rewiring degron network	0.25
p.R512W	SIDM00760	Small Cell Lung Carcinoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	515:520	Mutation rewiring degron network	0.25
p.R512W	SIDM00641	Burkitt's Lymphoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	515:520	Mutation rewiring degron network	0.25
p.R512W	SIDM01752	Pancreatic Carcinoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	515:520	Mutation rewiring degron network	0.25
p.Q518H	SIDM00656	Burkitt's Lymphoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	515:520	Mutation altering degron motif	0.7582
p.Q518H	SIDM00633	Breast Carcinoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	515:520	Mutation altering degron motif	0.7582
p.Q518H	SIDM01112	Osteosarcoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	515:520	Mutation altering degron motif	0.7582
p.Q518H	SIDM01099	Neuroblastoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	515:520	Mutation altering degron motif	0.7582
p.Q518H	SIDM00032	Bladder Carcinoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	515:520	Mutation altering degron motif	0.7582
p.Q518H	SIDM00760	Small Cell Lung Carcinoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	515:520	Mutation altering degron motif	0.7582
p.Q518H	SIDM00641	Burkitt's Lymphoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	515:520	Mutation altering degron motif	0.7582
p.Q518H	SIDM01752	Pancreatic Carcinoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	515:520	Mutation altering degron motif	0.7582
p.A191V	SIDM00013	Melanoma	GDSC	PRNVLNIIP	DEG_APCC_DBOX_1	173:181	Mutation rewiring degron network	0.0556
p.K73R	SIDM00706	Small Cell Lung Carcinoma	GDSC	SKENI	DEG_APCC_KENBOX_2	60:64	Mutation rewiring degron network	0.0833
p.K73R	NCI-H209	lung	COSMIC	SKENI	DEG_APCC_KENBOX_2	60:64	Mutation rewiring degron network	0.0833
p.M56T	SIDM00970	Bladder Carcinoma	GDSC	SKENI	DEG_APCC_KENBOX_2	60:64	Mutation rewiring degron network	0.2222
p.M56T	DSH1	urinary tract	COSMIC	SKENI	DEG_APCC_KENBOX_2	60:64	Mutation rewiring degron network	0.2222
p.N72H	SIDM00118	Colorectal Carcinoma	GDSC	SKENI	DEG_APCC_KENBOX_2	60:64	Mutation rewiring degron network	0.1111
p.N72H	HCC2998	large intestine	COSMIC	SKENI	DEG_APCC_KENBOX_2	60:64	Mutation rewiring degron network	0.1111
p.Q183K	SIDM00750	Non-Small Cell Lung Carcinoma	GDSC	PRNVLNIIP	DEG_APCC_DBOX_1	173:181	Mutation rewiring degron network	0.2778
p.Q183K	NCI-H1568	lung	COSMIC	PRNVLNIIP	DEG_APCC_DBOX_1	173:181	Mutation rewiring degron network	0.2778
p.R68S	ACH-000614	Skin Cancer	CCLE	SKENI	DEG_APCC_KENBOX_2	60:64	Mutation rewiring degron network	0.2222
p.R68S	RVH-421	skin	COSMIC	SKENI	DEG_APCC_KENBOX_2	60:64	Mutation rewiring degron network	0.2222
p.R63S	ACH-000820	Colon/Colorectal Cancer	CCLE	SKENI	DEG_APCC_KENBOX_2	60:64	Mutation altering degron motif	0.7427
p.R63S	SW403	large intestine	COSMIC	SKENI	DEG_APCC_KENBOX_2	60:64	Mutation altering degron motif	0.7427
p.Q56E	ACH-000840	Lung Cancer	CCLE	SKENI	DEG_APCC_KENBOX_2	60:64	Mutation rewiring degron network	0.2222
p.Q56E	HCC-366	lung	COSMIC	SKENI	DEG_APCC_KENBOX_2	60:64	Mutation rewiring degron network	0.2222
p.H190Y	ACH-000954	Endometrial/Uterine Cancer	CCLE	PRNVLNIIP	DEG_APCC_DBOX_1	173:181	Mutation rewiring degron network	0.0833
p.S520G	ACH-000997	Colon/Colorectal Cancer	CCLE	DSGSSS	DEG_SCF_TRCP1_1	515:520	Mutation altering degron motif	0.8104
p.S520G	HCT-15	large intestine	COSMIC	DSGSSS	DEG_SCF_TRCP1_1	515:520	Mutation altering degron motif	0.8104
p.A94T	ACH-000999	Colon/Colorectal Cancer	CCLE	NKENT	DEG_APCC_KENBOX_2	104:108	Mutation rewiring degron network	0.0556
p.A94T	SNU-1040	large intestine	COSMIC	NKENT	DEG_APCC_KENBOX_2	104:108	Mutation rewiring degron network	0.0556
p.N104D	ACH-002317	Leukemia	CCLE	NKENT	DEG_APCC_KENBOX_2	104:108	Mutation altering degron motif	0.5821
p.N104D	YT	haematopoietic and lymphoid tissue	COSMIC	NKENT	DEG_APCC_KENBOX_2	104:108	Mutation altering degron motif	0.5821
p.G51D	SNU-1040	large intestine	COSMIC	SKENI	DEG_APCC_KENBOX_2	60:64	Mutation rewiring degron network	0.0833
p.G58R	SW684	soft tissue	COSMIC	SKENI	DEG_APCC_KENBOX_2	60:64	Mutation rewiring degron network	0.2778
p.L51M	SNU-175	large intestine	COSMIC	SKENI	DEG_APCC_KENBOX_2	60:64	Mutation rewiring degron network	0.0833
p.I168S	H513	pleura	COSMIC	NKENT	DEG_APCC_KENBOX_2	168:172	Mutation altering degron motif	0.7341

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MEPE

UniProt ID: Q9NQ76

Entrez ID: 56955

Protein name: Matrix extracellular phosphoglycoprotein (Osteoblast/osteocyte factor 45) (OF45) (Osteoregulin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MEPE in