DegronMD

Uniprot ID: Q9NQ76

Source protein: Matrix extracellular phosphoglycoprotein

Source gene: MEPE

Class: DEG_APCC_KENBOX_2

Location: 60:64

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9125

ASA_SCORE: 94.24

COIL: 0.6144

CONS_SCORE: 0.3779

DSS_SCORE: 0.5262

HELIX: 0.373

FCONS_SCORE: 1.2138

RIG_SCORE: 0.711

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R53I	TCGA-BK-A6W3	UCEC	TCGA	SKENI	DEG_APCC_KENBOX_2	0.1389
p.S73F	TCGA-D3-A2JO	SKCM	TCGA	SKENI	DEG_APCC_KENBOX_2	0.0833
p.S73P	TCGA-DU-6392	LGG	TCGA	SKENI	DEG_APCC_KENBOX_2	0.0833
p.V65A	TCGA-FV-A496	LIHC	TCGA	SKENI	DEG_APCC_KENBOX_2	0.3056
p.Q56H	DO233950	GACA	ICGC	SKENI	DEG_APCC_KENBOX_2	0.2222
p.V50F	DO229015	LICA	ICGC	SKENI	DEG_APCC_KENBOX_2	0.0556
p.S60P	DO222420	MELA	ICGC	SKENI	DEG_APCC_KENBOX_2	0.5641
p.L51R	DO36556	READ	ICGC	SKENI	DEG_APCC_KENBOX_2	0.0833
p.P58R	SIDM00454	Rhabdomyosarcoma	GDSC	SKENI	DEG_APCC_KENBOX_2	0.2778
p.K73R	SIDM00706	Small Cell Lung Carcinoma	GDSC	SKENI	DEG_APCC_KENBOX_2	0.0833
p.K73R	NCI-H209	lung	COSMIC	SKENI	DEG_APCC_KENBOX_2	0.0833
p.M56T	SIDM00970	Bladder Carcinoma	GDSC	SKENI	DEG_APCC_KENBOX_2	0.2222
p.M56T	DSH1	urinary_tract	COSMIC	SKENI	DEG_APCC_KENBOX_2	0.2222
p.N72H	SIDM00118	Colorectal Carcinoma	GDSC	SKENI	DEG_APCC_KENBOX_2	0.1111
p.N72H	HCC2998	large_intestine	COSMIC	SKENI	DEG_APCC_KENBOX_2	0.1111
p.R68S	ACH-000614	Skin Cancer	CCLE	SKENI	DEG_APCC_KENBOX_2	0.2222
p.R68S	RVH-421	skin	COSMIC	SKENI	DEG_APCC_KENBOX_2	0.2222
p.R63S	ACH-000820	Colon/Colorectal Cancer	CCLE	SKENI	DEG_APCC_KENBOX_2	0.7427
p.R63S	SW403	large_intestine	COSMIC	SKENI	DEG_APCC_KENBOX_2	0.7427
p.Q56E	ACH-000840	Lung Cancer	CCLE	SKENI	DEG_APCC_KENBOX_2	0.2222
p.Q56E	HCC-366	lung	COSMIC	SKENI	DEG_APCC_KENBOX_2	0.2222
p.G51D	SNU-1040	large_intestine	COSMIC	SKENI	DEG_APCC_KENBOX_2	0.0833
p.G58R	SW684	soft_tissue	COSMIC	SKENI	DEG_APCC_KENBOX_2	0.2778
p.L51M	SNU-175	large_intestine	COSMIC	SKENI	DEG_APCC_KENBOX_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13521	Secretogranin-2	DEG_APCC_KENBOX_2	268:272	SKENI	APC,CDC20,FZR1	0.7451	More...
P51955	Serine/threonine-protein kinase Nek2	DEG_APCC_KENBOX_2	390:394	SKENI	APC,CDC20,FZR1	0.9566	More...
Q9NQ76	Matrix extracellular phosphoglycoprotein	DEG_APCC_KENBOX_2	60:64	SKENI	APC,CDC20,FZR1	0.9125	More...
Q9NQX3	Gephyrin [Includes: Molybdopterin adenylyltransferase	DEG_APCC_KENBOX_2	295:299	SKENI	APC,CDC20,FZR1	0.8364	More...
Q9NSY1	BMP-2-inducible protein kinase	DEG_APCC_KENBOX_2	1041:1045	SKENI	APC,CDC20,FZR1	0.9065	More...
Q9NYB5	Solute carrier organic anion transporter family member 1C1	DEG_APCC_KENBOX_2	5:9	SKENI	APC,CDC20,FZR1	0.9756	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons