DegronMD

Uniprot ID: Q9NSY1

Source protein: BMP-2-inducible protein kinase

Source gene: BMP2K

Class: DEG_APCC_KENBOX_2

Location: 1041:1045

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9065

ASA_SCORE: 89.98

COIL: 0.6204

CONS_SCORE: 0.2676

DSS_SCORE: 0.4211

HELIX: 0.2692

FCONS_SCORE: 1.0159

RIG_SCORE: 0.707

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1055K	TCGA-AD-A5EJ	COAD	TCGA	SKENI	DEG_APCC_KENBOX_2	0.0556
p.R1055K	TCGA-D3-A5GR	SKCM	TCGA	SKENI	DEG_APCC_KENBOX_2	0.0556
p.R1055K	DO50090	COAD	ICGC	SKENI	DEG_APCC_KENBOX_2	0.0556
p.R1055K	DO47436	SKCM	ICGC	SKENI	DEG_APCC_KENBOX_2	0.0556
p.D1051Y	TCGA-LT-A5Z6	BLCA	TCGA	SKENI	DEG_APCC_KENBOX_2	0.1667
p.D1051Y	DO44029	BLCA	ICGC	SKENI	DEG_APCC_KENBOX_2	0.1667
p.D1040H	SIDM00660	Colorectal Carcinoma	GDSC	SKENI	DEG_APCC_KENBOX_2	0.3056
p.D1040H	ACH-000985	Colon/Colorectal Cancer	CCLE	SKENI	DEG_APCC_KENBOX_2	0.3056
p.D1040H	LS-411N	large_intestine	COSMIC	SKENI	DEG_APCC_KENBOX_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13521	Secretogranin-2	DEG_APCC_KENBOX_2	268:272	SKENI	APC,CDC20,FZR1	0.7451	More...
P51955	Serine/threonine-protein kinase Nek2	DEG_APCC_KENBOX_2	390:394	SKENI	APC,CDC20,FZR1	0.9566	More...
Q9NQ76	Matrix extracellular phosphoglycoprotein	DEG_APCC_KENBOX_2	60:64	SKENI	APC,CDC20,FZR1	0.9125	More...
Q9NQX3	Gephyrin [Includes: Molybdopterin adenylyltransferase	DEG_APCC_KENBOX_2	295:299	SKENI	APC,CDC20,FZR1	0.8364	More...
Q9NSY1	BMP-2-inducible protein kinase	DEG_APCC_KENBOX_2	1041:1045	SKENI	APC,CDC20,FZR1	0.9065	More...
Q9NYB5	Solute carrier organic anion transporter family member 1C1	DEG_APCC_KENBOX_2	5:9	SKENI	APC,CDC20,FZR1	0.9756	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons