DegronMD

Uniprot ID: Q9NYB5

Source protein: Solute carrier organic anion transporter family member 1C1

Source gene: SLCO1C1

Class: DEG_APCC_KENBOX_2

Location: 5:9

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9756

ASA_SCORE: 109.66

COIL: 0.7568

CONS_SCORE: 0.4081

DSS_SCORE: 0.6488

HELIX: 0.2386

FCONS_SCORE: 1.225

RIG_SCORE: 0.747

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P19L	TCGA-34-7107	LUSC	TCGA	SKENI	DEG_APCC_KENBOX_2	0.0556
p.P19L	DO26449	LUSC	ICGC	SKENI	DEG_APCC_KENBOX_2	0.0556
p.P19T	TCGA-DD-AADG	LIHC	TCGA	SKENI	DEG_APCC_KENBOX_2	0.0556
p.P19T	DO219571	LIHC	ICGC	SKENI	DEG_APCC_KENBOX_2	0.0556
p.P19S	TCGA-EE-A2GC	SKCM	TCGA	SKENI	DEG_APCC_KENBOX_2	0.0556
p.P19S	DO37839	SKCM	ICGC	SKENI	DEG_APCC_KENBOX_2	0.0556
p.P19H	TCGA-FI-A2D5	UCEC	TCGA	SKENI	DEG_APCC_KENBOX_2	0.0556
p.P19H	DO41331	UCEC	ICGC	SKENI	DEG_APCC_KENBOX_2	0.0556
p.E7G	TCGA-W3-AA1V	SKCM	TCGA	SKENI	DEG_APCC_KENBOX_2	0.7199
p.E7G	DO51276	SKCM	ICGC	SKENI	DEG_APCC_KENBOX_2	0.7199
p.L6V	DO49800	BLCA	ICGC	SKENI	DEG_APCC_KENBOX_2	0.6765
p.F14S	DO598	BLCA	ICGC	SKENI	DEG_APCC_KENBOX_2	0.3056
p.E16D	DO8264	COAD	ICGC	SKENI	DEG_APCC_KENBOX_2	0.1389
p.E16D	DO229027	LICA	ICGC	SKENI	DEG_APCC_KENBOX_2	0.1389
p.F12L	DO233737	GACA	ICGC	SKENI	DEG_APCC_KENBOX_2	0.25
p.L11F	DO229015	LICA	ICGC	SKENI	DEG_APCC_KENBOX_2	0.2778
p.L7F	DO52319	LIHC	ICGC	SKENI	DEG_APCC_KENBOX_2	0.6981
p.Y18N	DO45345	LUAD	ICGC	SKENI	DEG_APCC_KENBOX_2	0.0833
p.G2V	DO45450	LUSC	ICGC	SKENI	DEG_APCC_KENBOX_2	0.6944
p.A9G	DO27279	LUSC	ICGC	SKENI	DEG_APCC_KENBOX_2	0.754
p.G2E	DO222731	MELA	ICGC	SKENI	DEG_APCC_KENBOX_2	0.6944
p.C13Y	DO33432	PACA	ICGC	SKENI	DEG_APCC_KENBOX_2	0.2222
p.F13L	DO36556	READ	ICGC	SKENI	DEG_APCC_KENBOX_2	0.2222
p.G2R	DO220056	SARC	ICGC	SKENI	DEG_APCC_KENBOX_2	0.6944
p.G4E	DO50301	SKCM	ICGC	SKENI	DEG_APCC_KENBOX_2	0.4167
p.G4R	DO48665	SKCM	ICGC	SKENI	DEG_APCC_KENBOX_2	0.4167
p.Q17H	NEC8	testis	COSMIC	SKENI	DEG_APCC_KENBOX_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13521	Secretogranin-2	DEG_APCC_KENBOX_2	268:272	SKENI	APC,CDC20,FZR1	0.7451	More...
P51955	Serine/threonine-protein kinase Nek2	DEG_APCC_KENBOX_2	390:394	SKENI	APC,CDC20,FZR1	0.9566	More...
Q9NQ76	Matrix extracellular phosphoglycoprotein	DEG_APCC_KENBOX_2	60:64	SKENI	APC,CDC20,FZR1	0.9125	More...
Q9NQX3	Gephyrin [Includes: Molybdopterin adenylyltransferase	DEG_APCC_KENBOX_2	295:299	SKENI	APC,CDC20,FZR1	0.8364	More...
Q9NSY1	BMP-2-inducible protein kinase	DEG_APCC_KENBOX_2	1041:1045	SKENI	APC,CDC20,FZR1	0.9065	More...
Q9NYB5	Solute carrier organic anion transporter family member 1C1	DEG_APCC_KENBOX_2	5:9	SKENI	APC,CDC20,FZR1	0.9756	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons