DegronMD

Uniprot ID: Q9NQX3

Source protein: Gephyrin [Includes: Molybdopterin adenylyltransferase

Source gene: GPHN

Class: DEG_APCC_KENBOX_2

Location: 295:299

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8364

ASA_SCORE: 92.62

COIL: 0.4258

CONS_SCORE: 0.1881

DSS_SCORE: 0.4799

HELIX: 0.5658

FCONS_SCORE: 0.9727

RIG_SCORE: 0.6992

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S297T	TCGA-23-1032	OV	TCGA	SKENI	DEG_APCC_KENBOX_2	0.7116
p.S297T	DO32267	OV	ICGC	SKENI	DEG_APCC_KENBOX_2	0.7116
p.P304S	TCGA-A5-A1OF	UCEC	TCGA	SKENI	DEG_APCC_KENBOX_2	0.1944
p.S303L	TCGA-BR-4201	STAD	TCGA	SKENI	DEG_APCC_KENBOX_2	0.6667
p.S303L	DO38707	STAD	ICGC	SKENI	DEG_APCC_KENBOX_2	0.6667
p.D292H	TCGA-BR-7716	STAD	TCGA	SKENI	DEG_APCC_KENBOX_2	0.25
p.D292H	DO38675	STAD	ICGC	SKENI	DEG_APCC_KENBOX_2	0.25
p.P300L	TCGA-FI-A2D0	UCEC	TCGA	SKENI	DEG_APCC_KENBOX_2	0.3056
p.P300L	SIDM00545	Melanoma	GDSC	SKENI	DEG_APCC_KENBOX_2	0.3056
p.P300L	ACH-000987	Skin Cancer	CCLE	SKENI	DEG_APCC_KENBOX_2	0.3056
p.P300L	Mewo	skin	COSMIC	SKENI	DEG_APCC_KENBOX_2	0.3056
p.R291Q	TCGA-GN-A263	SKCM	TCGA	SKENI	DEG_APCC_KENBOX_2	0.6667
p.R291Q	DO37766	SKCM	ICGC	SKENI	DEG_APCC_KENBOX_2	0.6667
p.S297C	TCGA-WE-A8ZR	SKCM	TCGA	SKENI	DEG_APCC_KENBOX_2	0.7541
p.M305I	DO51927	BLCA	ICGC	SKENI	DEG_APCC_KENBOX_2	0.6111
p.T306S	DO228353	MALY	ICGC	SKENI	DEG_APCC_KENBOX_2	0.1389
p.R291L	DO46420	OV	ICGC	SKENI	DEG_APCC_KENBOX_2	0.6667
p.P291S	DO229446	SKCA	ICGC	SKENI	DEG_APCC_KENBOX_2	0.6667
p.P300S	DO218849	SKCA	ICGC	SKENI	DEG_APCC_KENBOX_2	0.3056
p.P307L	DO52402	UCEC	ICGC	SKENI	DEG_APCC_KENBOX_2	0.1111
p.S288Y	DO43971	UCEC	ICGC	SKENI	DEG_APCC_KENBOX_2	0.25
p.A294V	SIDM02021	Esophageal Carcinoma	GDSC	SKENI	DEG_APCC_KENBOX_2	0.75
p.Q307H	SIDM00721	Small Cell Lung Carcinoma	GDSC	SKENI	DEG_APCC_KENBOX_2	0.1111
p.Q307H	ACH-002171	Lung Cancer	CCLE	SKENI	DEG_APCC_KENBOX_2	0.1111
p.Q307H	NCI-H250	lung	COSMIC	SKENI	DEG_APCC_KENBOX_2	0.1111
p.A294T	ACH-001735	Leukemia	CCLE	SKENI	DEG_APCC_KENBOX_2	0.75
p.Q289H	NCI-H250	lung	COSMIC	SKENI	DEG_APCC_KENBOX_2	0.1667
p.Q287H	NCI-H250	lung	COSMIC	SKENI	DEG_APCC_KENBOX_2	0.1111
p.I309V	CW-2	large_intestine	COSMIC	SKENI	DEG_APCC_KENBOX_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13521	Secretogranin-2	DEG_APCC_KENBOX_2	268:272	SKENI	APC,CDC20,FZR1	0.7451	More...
P51955	Serine/threonine-protein kinase Nek2	DEG_APCC_KENBOX_2	390:394	SKENI	APC,CDC20,FZR1	0.9566	More...
Q9NQ76	Matrix extracellular phosphoglycoprotein	DEG_APCC_KENBOX_2	60:64	SKENI	APC,CDC20,FZR1	0.9125	More...
Q9NQX3	Gephyrin [Includes: Molybdopterin adenylyltransferase	DEG_APCC_KENBOX_2	295:299	SKENI	APC,CDC20,FZR1	0.8364	More...
Q9NSY1	BMP-2-inducible protein kinase	DEG_APCC_KENBOX_2	1041:1045	SKENI	APC,CDC20,FZR1	0.9065	More...
Q9NYB5	Solute carrier organic anion transporter family member 1C1	DEG_APCC_KENBOX_2	5:9	SKENI	APC,CDC20,FZR1	0.9756	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SKENI

Degron related mutations and impact score

Drug responses associated with GPHN mutations

All proteins holding degron of SKENI