DegronMD - Q9NYB5(SLCO1C1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K699N	TCGA-18-3409	LUSC	TCGA	QKENY	DEG_APCC_KENBOX_2	689:693	Mutation rewiring degron network	0.1667
p.P19L	TCGA-34-7107	LUSC	TCGA	SKENI	DEG_APCC_KENBOX_2	5:9	Mutation rewiring degron network	0.0556
p.P19L	DO26449	LUSC	ICGC	SKENI	DEG_APCC_KENBOX_2	5:9	Mutation rewiring degron network	0.0556
p.E700D	TCGA-3B-A9HY	SARC	TCGA	QKENY	DEG_APCC_KENBOX_2	689:693	Mutation rewiring degron network	0.1389
p.T683N	TCGA-44-7660	LUAD	TCGA	QKENY	DEG_APCC_KENBOX_2	689:693	Mutation rewiring degron network	0.1667
p.T695I	TCGA-BS-A0UV	UCEC	TCGA	QKENY	DEG_APCC_KENBOX_2	689:693	Mutation rewiring degron network	0.2778
p.P19T	TCGA-DD-AADG	LIHC	TCGA	SKENI	DEG_APCC_KENBOX_2	5:9	Mutation rewiring degron network	0.0556
p.P19T	DO219571	LIHC	ICGC	SKENI	DEG_APCC_KENBOX_2	5:9	Mutation rewiring degron network	0.0556
p.P690H	TCGA-DF-A2KN	UCEC	TCGA	QKENY	DEG_APCC_KENBOX_2	689:693	Mutation altering degron motif	0.7694
p.P19S	TCGA-EE-A2GC	SKCM	TCGA	SKENI	DEG_APCC_KENBOX_2	5:9	Mutation rewiring degron network	0.0556
p.P19S	DO37839	SKCM	ICGC	SKENI	DEG_APCC_KENBOX_2	5:9	Mutation rewiring degron network	0.0556
p.P19H	TCGA-FI-A2D5	UCEC	TCGA	SKENI	DEG_APCC_KENBOX_2	5:9	Mutation rewiring degron network	0.0556
p.P19H	DO41331	UCEC	ICGC	SKENI	DEG_APCC_KENBOX_2	5:9	Mutation rewiring degron network	0.0556
p.T679N	TCGA-R5-A7ZR	STAD	TCGA	QKENY	DEG_APCC_KENBOX_2	689:693	Mutation rewiring degron network	0.0556
p.E7G	TCGA-W3-AA1V	SKCM	TCGA	SKENI	DEG_APCC_KENBOX_2	5:9	Mutation altering degron motif	0.7199
p.E7G	DO51276	SKCM	ICGC	SKENI	DEG_APCC_KENBOX_2	5:9	Mutation altering degron motif	0.7199
p.L6V	DO49800	BLCA	ICGC	SKENI	DEG_APCC_KENBOX_2	5:9	Mutation altering degron motif	0.6765
p.F14S	DO598	BLCA	ICGC	SKENI	DEG_APCC_KENBOX_2	5:9	Mutation substituting flanking lysine	0.3056
p.E16D	DO8264	COAD	ICGC	SKENI	DEG_APCC_KENBOX_2	5:9	Mutation rewiring degron network	0.1389
p.E16D	DO229027	LICA	ICGC	SKENI	DEG_APCC_KENBOX_2	5:9	Mutation rewiring degron network	0.1389
p.F12L	DO233737	GACA	ICGC	SKENI	DEG_APCC_KENBOX_2	5:9	Mutation rewiring degron network	0.25
p.L11F	DO229015	LICA	ICGC	SKENI	DEG_APCC_KENBOX_2	5:9	Mutation rewiring degron network	0.2778
p.L7F	DO52319	LIHC	ICGC	SKENI	DEG_APCC_KENBOX_2	5:9	Mutation altering degron motif	0.6981
p.Y18N	DO45345	LUAD	ICGC	SKENI	DEG_APCC_KENBOX_2	5:9	Mutation rewiring degron network	0.0833
p.G2V	DO45450	LUSC	ICGC	SKENI	DEG_APCC_KENBOX_2	5:9	Mutation blocking ubiquitination signal	0.6944
p.A9G	DO27279	LUSC	ICGC	SKENI	DEG_APCC_KENBOX_2	5:9	Mutation altering degron motif	0.754
p.G2E	DO222731	MELA	ICGC	SKENI	DEG_APCC_KENBOX_2	5:9	Mutation blocking ubiquitination signal	0.6944
p.C13Y	DO33432	PACA	ICGC	SKENI	DEG_APCC_KENBOX_2	5:9	Mutation rewiring degron network	0.2222
p.F13L	DO36556	READ	ICGC	SKENI	DEG_APCC_KENBOX_2	5:9	Mutation rewiring degron network	0.2222
p.G2R	DO220056	SARC	ICGC	SKENI	DEG_APCC_KENBOX_2	5:9	Mutation blocking ubiquitination signal	0.6944
p.G4E	DO50301	SKCM	ICGC	SKENI	DEG_APCC_KENBOX_2	5:9	Mutation substituting flanking lysine	0.4167
p.G4R	DO48665	SKCM	ICGC	SKENI	DEG_APCC_KENBOX_2	5:9	Mutation substituting flanking lysine	0.4167
p.N688D	SIDM02035	Colorectal Carcinoma	GDSC	QKENY	DEG_APCC_KENBOX_2	689:693	Mutation rewiring degron network	0.3056
p.H697Y	SIDM00003	Melanoma	GDSC	QKENY	DEG_APCC_KENBOX_2	689:693	Mutation rewiring degron network	0.2222
p.H697Y	M14	skin	COSMIC	QKENY	DEG_APCC_KENBOX_2	689:693	Mutation rewiring degron network	0.2222
p.T695N	SIDM00118	Colorectal Carcinoma	GDSC	QKENY	DEG_APCC_KENBOX_2	689:693	Mutation rewiring degron network	0.2778
p.T695N	HCC2998	large intestine	COSMIC	QKENY	DEG_APCC_KENBOX_2	689:693	Mutation rewiring degron network	0.2778
p.T694S	ACH-000872	Lung Cancer	CCLE	QKENY	DEG_APCC_KENBOX_2	689:693	Mutation rewiring degron network	0.3056
p.N703K	ACH-000984	Endometrial/Uterine Cancer	CCLE	QKENY	DEG_APCC_KENBOX_2	689:693	Mutation rewiring degron network	0.0556
p.R687I	ACH-000991	Colon/Colorectal Cancer	CCLE	QKENY	DEG_APCC_KENBOX_2	689:693	Mutation rewiring degron network	0.2778
p.R687I	SNU-81	large intestine	COSMIC	QKENY	DEG_APCC_KENBOX_2	689:693	Mutation rewiring degron network	0.2778
p.T686A	ACH-001345	Colon/Colorectal Cancer	CCLE	QKENY	DEG_APCC_KENBOX_2	689:693	Mutation rewiring degron network	0.25
p.T686A	GP5d	large intestine	COSMIC	QKENY	DEG_APCC_KENBOX_2	689:693	Mutation rewiring degron network	0.25
p.E691K	ACH-002084	Skin Cancer	CCLE	QKENY	DEG_APCC_KENBOX_2	689:693	Mutation altering degron motif	0.7022
p.E691K	ACH-002098	Skin Cancer	CCLE	QKENY	DEG_APCC_KENBOX_2	689:693	Mutation altering degron motif	0.7022
p.E691K	ACH-002162	Skin Cancer	CCLE	QKENY	DEG_APCC_KENBOX_2	689:693	Mutation altering degron motif	0.7022
p.E691K	CP67-MEL	skin	COSMIC	QKENY	DEG_APCC_KENBOX_2	689:693	Mutation altering degron motif	0.7022
p.E691K	MMAC-SF	skin	COSMIC	QKENY	DEG_APCC_KENBOX_2	689:693	Mutation altering degron motif	0.7022
p.F688L	ACH-002178	Bone Cancer	CCLE	QKENY	DEG_APCC_KENBOX_2	689:693	Mutation rewiring degron network	0.3056
p.Q17H	NEC8	testis	COSMIC	SKENI	DEG_APCC_KENBOX_2	5:9	Mutation rewiring degron network	0.1111

Kaplan plot for SLCO1C1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLCO1C1

UniProt ID: Q9NYB5

Entrez ID: 53919

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLCO1C1 in