DegronMD

Uniprot ID: Q9NYB5

Source protein: Solute carrier organic anion transporter family member 1C1

Source gene: SLCO1C1

Class: DEG_APCC_KENBOX_2

Location: 689:693

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7564

ASA_SCORE: 121.96

COIL: 0.7976

CONS_SCORE: 0.2737

DSS_SCORE: 0.4102

HELIX: 0.1734

FCONS_SCORE: 1.1055

RIG_SCORE: 0.7606

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K699N	TCGA-18-3409	LUSC	TCGA	QKENY	DEG_APCC_KENBOX_2	0.1667
p.E700D	TCGA-3B-A9HY	SARC	TCGA	QKENY	DEG_APCC_KENBOX_2	0.1389
p.T683N	TCGA-44-7660	LUAD	TCGA	QKENY	DEG_APCC_KENBOX_2	0.1667
p.T695I	TCGA-BS-A0UV	UCEC	TCGA	QKENY	DEG_APCC_KENBOX_2	0.2778
p.P690H	TCGA-DF-A2KN	UCEC	TCGA	QKENY	DEG_APCC_KENBOX_2	0.7694
p.T679N	TCGA-R5-A7ZR	STAD	TCGA	QKENY	DEG_APCC_KENBOX_2	0.0556
p.N688D	SIDM02035	Colorectal Carcinoma	GDSC	QKENY	DEG_APCC_KENBOX_2	0.3056
p.H697Y	SIDM00003	Melanoma	GDSC	QKENY	DEG_APCC_KENBOX_2	0.2222
p.H697Y	M14	skin	COSMIC	QKENY	DEG_APCC_KENBOX_2	0.2222
p.T695N	SIDM00118	Colorectal Carcinoma	GDSC	QKENY	DEG_APCC_KENBOX_2	0.2778
p.T695N	HCC2998	large_intestine	COSMIC	QKENY	DEG_APCC_KENBOX_2	0.2778
p.T694S	ACH-000872	Lung Cancer	CCLE	QKENY	DEG_APCC_KENBOX_2	0.3056
p.N703K	ACH-000984	Endometrial/Uterine Cancer	CCLE	QKENY	DEG_APCC_KENBOX_2	0.0556
p.R687I	ACH-000991	Colon/Colorectal Cancer	CCLE	QKENY	DEG_APCC_KENBOX_2	0.2778
p.R687I	SNU-81	large_intestine	COSMIC	QKENY	DEG_APCC_KENBOX_2	0.2778
p.T686A	ACH-001345	Colon/Colorectal Cancer	CCLE	QKENY	DEG_APCC_KENBOX_2	0.25
p.T686A	GP5d	large_intestine	COSMIC	QKENY	DEG_APCC_KENBOX_2	0.25
p.E691K	ACH-002084	Skin Cancer	CCLE	QKENY	DEG_APCC_KENBOX_2	0.7022
p.E691K	ACH-002098	Skin Cancer	CCLE	QKENY	DEG_APCC_KENBOX_2	0.7022
p.E691K	ACH-002162	Skin Cancer	CCLE	QKENY	DEG_APCC_KENBOX_2	0.7022
p.E691K	CP67-MEL	skin	COSMIC	QKENY	DEG_APCC_KENBOX_2	0.7022
p.E691K	MMAC-SF	skin	COSMIC	QKENY	DEG_APCC_KENBOX_2	0.7022
p.F688L	ACH-002178	Bone Cancer	CCLE	QKENY	DEG_APCC_KENBOX_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NYB5	Solute carrier organic anion transporter family member 1C1	DEG_APCC_KENBOX_2	689:693	QKENY	APC,CDC20,FZR1	0.7564	More...
Q12796	Proline-rich nuclear receptor coactivator 1	DEG_APCC_KENBOX_2	275:279	QKENY	APC,CDC20,FZR1	0.8202	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons