DegronMD

Uniprot ID: Q12796

Source protein: Proline-rich nuclear receptor coactivator 1

Source gene: PNRC1

Class: DEG_APCC_KENBOX_2

Location: 275:279

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8202

ASA_SCORE: 98.62

COIL: 0.6408

CONS_SCORE: 0.9722

DSS_SCORE: 0.4543

HELIX: 0.3026

FCONS_SCORE: 1.0769

RIG_SCORE: 0.7062

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K265N	TCGA-18-3417	LUSC	TCGA	QKENY	DEG_APCC_KENBOX_2	0.1667
p.K265N	DO26584	LUSC	ICGC	QKENY	DEG_APCC_KENBOX_2	0.1667
p.N278K	TCGA-WN-A9G9	KIRP	TCGA	QKENY	DEG_APCC_KENBOX_2	0.6918
p.N278K	DO51569	KIRP	ICGC	QKENY	DEG_APCC_KENBOX_2	0.6918
p.D286Y	SIDM01591	Breast Carcinoma	GDSC	QKENY	DEG_APCC_KENBOX_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NYB5	Solute carrier organic anion transporter family member 1C1	DEG_APCC_KENBOX_2	689:693	QKENY	APC,CDC20,FZR1	0.7564	More...
Q12796	Proline-rich nuclear receptor coactivator 1	DEG_APCC_KENBOX_2	275:279	QKENY	APC,CDC20,FZR1	0.8202	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons