DegronMD - P51955(NEK2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G388E	TCGA-05-4250	LUAD	TCGA	SKENI	DEG_APCC_KENBOX_2	390:394	Mutation rewiring degron network	0.2778
p.G388R	TCGA-06-6389	GBM	TCGA	SKENI	DEG_APCC_KENBOX_2	390:394	Mutation rewiring degron network	0.2778
p.S402G	TCGA-A3-A6NN	KIRC	TCGA	SKENI	DEG_APCC_KENBOX_2	390:394	Mutation blocking phosphorylation signal	0.5556
p.G443C	TCGA-A5-A0VP	UCEC	TCGA	GMR	DEG_APCC_TPR_1	443:445	Mutation altering degron motif	0.6489
p.G443C	DO42600	UCEC	ICGC	GMR	DEG_APCC_TPR_1	443:445	Mutation altering degron motif	0.6489
p.N433K	TCGA-D1-A0ZS	UCEC	TCGA	GMR	DEG_APCC_TPR_1	443:445	Mutation rewiring degron network	0.0556
p.Q435K	TCGA-D3-A3CE	SKCM	TCGA	GMR	DEG_APCC_TPR_1	443:445	Mutation rewiring degron network	0.1111
p.S385P	DO232761	PBCA	ICGC	SKENI	DEG_APCC_KENBOX_2	390:394	Mutation rewiring degron network	0.1944
p.Q392K	DO37405	SKCM	ICGC	SKENI	DEG_APCC_KENBOX_2	390:394	Mutation altering degron motif	0.6944
p.R380L	DO47407	SKCM	ICGC	SKENI	DEG_APCC_KENBOX_2	390:394	Mutation rewiring degron network	0.0556
p.W381L	DO229208	THCA	ICGC	SKENI	DEG_APCC_KENBOX_2	390:394	Mutation blocking ubiquitination signal	0.5278
p.N390K	DO43626	UCEC	ICGC	SKENI	DEG_APCC_KENBOX_2	390:394	Mutation altering degron motif	0.6918
p.R380Q	DO41704	UCEC	ICGC	SKENI	DEG_APCC_KENBOX_2	390:394	Mutation rewiring degron network	0.0556
p.Q403P	SIDM02021	Esophageal Carcinoma	GDSC	SKENI	DEG_APCC_KENBOX_2	390:394	Mutation rewiring degron network	0.0833
p.S387N	SIDM00422	Hodgkin's Lymphoma	GDSC	SKENI	DEG_APCC_KENBOX_2	390:394	Mutation rewiring degron network	0.25
p.S387N	ACH-001203	Lymphoma	CCLE	SKENI	DEG_APCC_KENBOX_2	390:394	Mutation rewiring degron network	0.25
p.S387N	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	SKENI	DEG_APCC_KENBOX_2	390:394	Mutation rewiring degron network	0.25
p.L436P	SIDM01119	Other Solid Cancers	GDSC	GMR	DEG_APCC_TPR_1	443:445	Mutation rewiring degron network	0.1389
p.L436P	NCI-H727	lung	COSMIC	GMR	DEG_APCC_TPR_1	443:445	Mutation rewiring degron network	0.1389
p.N393K	SIDM01039	Other Solid Cancers	GDSC	SKENI	DEG_APCC_KENBOX_2	390:394	Mutation altering degron motif	0.6918
p.N393K	ACH-001529	Endometrial/Uterine Cancer	CCLE	SKENI	DEG_APCC_KENBOX_2	390:394	Mutation altering degron motif	0.6918
p.N393K	JAR	placenta	COSMIC	SKENI	DEG_APCC_KENBOX_2	390:394	Mutation altering degron motif	0.6918
p.S438C	ACH-001060	Lymphoma	CCLE	GMR	DEG_APCC_TPR_1	443:445	Mutation blocking phosphorylation signal	0.6389

Kaplan plot for NEK2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NEK2

UniProt ID: P51955

Entrez ID: 4751

Protein name: Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (HSPK 21) (Never in mitosis A-related kinase 2) (NimA-related protein kinase 2) (NimA-like protein kinase 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NEK2 in