DegronMD

Uniprot ID: P51955

Source protein: Serine/threonine-protein kinase Nek2

Source gene: NEK2

Class: DEG_APCC_TPR_1

Location: 443:445

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9984

ASA_SCORE: 124.3

COIL: 0.7993

CONS_SCORE: 0.4828

DSS_SCORE: 0.7849

HELIX: 0.1833

FCONS_SCORE: 1.1981

RIG_SCORE: 0.7392

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G443C	TCGA-A5-A0VP	UCEC	TCGA	GMR	DEG_APCC_TPR_1	0.6489
p.G443C	DO42600	UCEC	ICGC	GMR	DEG_APCC_TPR_1	0.6489
p.N433K	TCGA-D1-A0ZS	UCEC	TCGA	GMR	DEG_APCC_TPR_1	0.0556
p.Q435K	TCGA-D3-A3CE	SKCM	TCGA	GMR	DEG_APCC_TPR_1	0.1111
p.L436P	SIDM01119	Other Solid Cancers	GDSC	GMR	DEG_APCC_TPR_1	0.1389
p.L436P	NCI-H727	lung	COSMIC	GMR	DEG_APCC_TPR_1	0.1389
p.S438C	ACH-001060	Lymphoma	CCLE	GMR	DEG_APCC_TPR_1	0.6389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51955	Serine/threonine-protein kinase Nek2	DEG_APCC_TPR_1	443:445	GMR	APC,CDC20,FZR1	0.9984	More...
Q96L96	Alpha-protein kinase 3	DEG_APCC_TPR_1	1905:1907	GMR	APC,CDC20,FZR1	0.9603	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons