DegronMD - Q96L96(ALPK3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H1125Q	TCGA-18-3416	LUSC	TCGA	LGTPTQS	DEG_SCF_FBW7_1	1118:1124	Mutation rewiring degron network	0.3056
p.H1125Q	DO26423	LUSC	ICGC	LGTPTQS	DEG_SCF_FBW7_1	1118:1124	Mutation rewiring degron network	0.3056
p.H670D	TCGA-43-5668	LUSC	TCGA	LTPQPT	DEG_SCF_FBW7_1	672:677	Mutation rewiring degron network	0.2778
p.H670D	DO26608	LUSC	ICGC	LTPQPT	DEG_SCF_FBW7_1	672:677	Mutation rewiring degron network	0.2778
p.T1113I	TCGA-58-A46J	LUSC	TCGA	LGTPTQS	DEG_SCF_FBW7_1	1118:1124	Mutation rewiring degron network	0.1944
p.T1113I	DO231141	LUSC	ICGC	LGTPTQS	DEG_SCF_FBW7_1	1118:1124	Mutation rewiring degron network	0.1944
p.T1113I	DO45532	LUSC	ICGC	LGTPTQS	DEG_SCF_FBW7_1	1118:1124	Mutation rewiring degron network	0.1944
p.K683N	TCGA-85-8351	LUSC	TCGA	LTPQPT	DEG_SCF_FBW7_1	672:677	Mutation substituting flanking lysine	0.2778
p.K683N	DO45447	LUSC	ICGC	LTPQPT	DEG_SCF_FBW7_1	672:677	Mutation substituting flanking lysine	0.2778
p.E956D	TCGA-A5-A0G1	UCEC	TCGA	VQTPEGS	DEG_SCF_FBW7_1	959:965	Mutation rewiring degron network	0.25
p.E956D	DO42472	UCEC	ICGC	VQTPEGS	DEG_SCF_FBW7_1	959:965	Mutation rewiring degron network	0.25
p.S1213L	TCGA-A5-A0G2	UCEC	TCGA	SRRILERVE	DEG_APCC_DBOX_1	1213:1221	Mutation altering degron motif	0.6556
p.S1213L	TCGA-AX-A2HC	UCEC	TCGA	SRRILERVE	DEG_APCC_DBOX_1	1213:1221	Mutation altering degron motif	0.6556
p.S1213L	DO222662	MELA	ICGC	SRRILERVE	DEG_APCC_DBOX_1	1213:1221	Mutation altering degron motif	0.6556
p.S1213L	DO41572	UCEC	ICGC	SRRILERVE	DEG_APCC_DBOX_1	1213:1221	Mutation altering degron motif	0.6556
p.S1213L	DO41235	UCEC	ICGC	SRRILERVE	DEG_APCC_DBOX_1	1213:1221	Mutation altering degron motif	0.6556
p.P687H	TCGA-AP-A051	UCEC	TCGA	LTPQPT	DEG_SCF_FBW7_1	672:677	Mutation rewiring degron network	0.0556
p.P687H	DO42673	UCEC	ICGC	LTPQPT	DEG_SCF_FBW7_1	672:677	Mutation rewiring degron network	0.0556
p.R1907W	TCGA-AX-A1CE	UCEC	TCGA	GMR	DEG_APCC_TPR_1	1905:1907	Mutation altering degron motif	0.8634
p.R1907W	DO42280	UCEC	ICGC	GMR	DEG_APCC_TPR_1	1905:1907	Mutation altering degron motif	0.8634
p.R1907W	ACH-001518	Endometrial/Uterine Cancer	CCLE	GMR	DEG_APCC_TPR_1	1905:1907	Mutation altering degron motif	0.8634
p.I955V	TCGA-BG-A0VT	UCEC	TCGA	VQTPEGS	DEG_SCF_FBW7_1	959:965	Mutation rewiring degron network	0.2222
p.I955V	DO41935	UCEC	ICGC	VQTPEGS	DEG_SCF_FBW7_1	959:965	Mutation rewiring degron network	0.2222
p.L86F	TCGA-BG-A222	UCEC	TCGA	PGSST	DEG_SPOP_SBC_1	77:81	Mutation rewiring degron network	0.1944
p.L86F	DO42977	UCEC	ICGC	PGSST	DEG_SPOP_SBC_1	77:81	Mutation rewiring degron network	0.1944
p.G1191E	TCGA-BR-4363	STAD	TCGA	LTPTVE	DEG_SCF_FBW7_2	1199:1204	Mutation rewiring degron network	0.1111
p.G1191E	DO38815	STAD	ICGC	LTPTVE	DEG_SCF_FBW7_2	1199:1204	Mutation rewiring degron network	0.1111
p.A664T	TCGA-BS-A0UV	UCEC	TCGA	LTPQPT	DEG_SCF_FBW7_1	672:677	Mutation rewiring degron network	0.1111
p.A664T	DO42793	UCEC	ICGC	LTPQPT	DEG_SCF_FBW7_1	672:677	Mutation rewiring degron network	0.1111
p.T669I	TCGA-CD-A4MJ	STAD	TCGA	LTPQPT	DEG_SCF_FBW7_1	672:677	Mutation rewiring degron network	0.25
p.T669I	DO47811	STAD	ICGC	LTPQPT	DEG_SCF_FBW7_1	672:677	Mutation rewiring degron network	0.25
p.Q1227H	TCGA-D3-A3C7	SKCM	TCGA	SRRILERVE	DEG_APCC_DBOX_1	1213:1221	Mutation rewiring degron network	0.1667
p.Q1227H	TCGA-DS-A1OB	CESC	TCGA	SRRILERVE	DEG_APCC_DBOX_1	1213:1221	Mutation rewiring degron network	0.1667
p.Q1227H	DO6323	CESC	ICGC	SRRILERVE	DEG_APCC_DBOX_1	1213:1221	Mutation rewiring degron network	0.1667
p.Q1227H	DO233702	GACA	ICGC	SRRILERVE	DEG_APCC_DBOX_1	1213:1221	Mutation rewiring degron network	0.1667
p.Q1227H	DO47569	SKCM	ICGC	SRRILERVE	DEG_APCC_DBOX_1	1213:1221	Mutation rewiring degron network	0.1667
p.P687S	TCGA-D9-A6EC	SKCM	TCGA	LTPQPT	DEG_SCF_FBW7_1	672:677	Mutation rewiring degron network	0.0556
p.P687S	DO50291	SKCM	ICGC	LTPQPT	DEG_SCF_FBW7_1	672:677	Mutation rewiring degron network	0.0556
p.A767V	TCGA-DI-A1BU	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	767:771	Mutation altering degron motif	0.5825
p.A767V	DO42023	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	767:771	Mutation altering degron motif	0.5825
p.Q1904K	TCGA-E8-A2EA	THCA	TCGA	GMR	DEG_APCC_TPR_1	1905:1907	Mutation rewiring degron network	0.3056
p.Q1904K	DO38926	THCA	ICGC	GMR	DEG_APCC_TPR_1	1905:1907	Mutation rewiring degron network	0.3056
p.R682I	TCGA-FS-A1Z0	SKCM	TCGA	LTPQPT	DEG_SCF_FBW7_1	672:677	Mutation rewiring degron network	0.1944
p.R682I	DO37431	SKCM	ICGC	LTPQPT	DEG_SCF_FBW7_1	672:677	Mutation rewiring degron network	0.1944
p.P949L	TCGA-FS-A1ZK	SKCM	TCGA	VQTPEGS	DEG_SCF_FBW7_1	959:965	Mutation rewiring degron network	0.0556
p.P949L	DO37474	SKCM	ICGC	VQTPEGS	DEG_SCF_FBW7_1	959:965	Mutation rewiring degron network	0.0556
p.P1112T	TCGA-FS-A1ZR	SKCM	TCGA	LGTPTQS	DEG_SCF_FBW7_1	1118:1124	Mutation rewiring degron network	0.1667
p.P1112T	DO37651	SKCM	ICGC	LGTPTQS	DEG_SCF_FBW7_1	1118:1124	Mutation rewiring degron network	0.1667
p.G1905S	TCGA-FS-A1ZW	SKCM	TCGA	GMR	DEG_APCC_TPR_1	1905:1907	Mutation altering degron motif	0.5882
p.G1905S	DO37519	SKCM	ICGC	GMR	DEG_APCC_TPR_1	1905:1907	Mutation altering degron motif	0.5882
p.R1415C	TCGA-G4-6586	COAD	TCGA	PGTPGRE	DEG_SCF_FBW7_2	1407:1413	Mutation rewiring degron network	0.2778
p.R1415C	DO9698	COAD	ICGC	PGTPGRE	DEG_SCF_FBW7_2	1407:1413	Mutation rewiring degron network	0.2778
p.R1211W	TCGA-HU-A4H3	STAD	TCGA	SRRILERVE	DEG_APCC_DBOX_1	1213:1221	Mutation rewiring degron network	0.2778
p.R1211W	TCGA-HU-A4H3	STAD	TCGA	LTPTVE	DEG_SCF_FBW7_2	1199:1204	Mutation rewiring degron network	0.1389
p.R1211W	DO47903	STAD	ICGC	SRRILERVE	DEG_APCC_DBOX_1	1213:1221	Mutation rewiring degron network	0.2778
p.R1211W	DO47903	STAD	ICGC	LTPTVE	DEG_SCF_FBW7_2	1199:1204	Mutation rewiring degron network	0.1389
p.R1211W	SIDM00999	Bladder Carcinoma	GDSC	SRRILERVE	DEG_APCC_DBOX_1	1213:1221	Mutation rewiring degron network	0.2778
p.R1211W	SIDM00999	Bladder Carcinoma	GDSC	LTPTVE	DEG_SCF_FBW7_2	1199:1204	Mutation rewiring degron network	0.1389
p.R1211W	ACH-000973	Bladder Cancer	CCLE	SRRILERVE	DEG_APCC_DBOX_1	1213:1221	Mutation rewiring degron network	0.2778
p.R1211W	ACH-000973	Bladder Cancer	CCLE	LTPTVE	DEG_SCF_FBW7_2	1199:1204	Mutation rewiring degron network	0.1389
p.R1211W	639-V	urinary tract	COSMIC	SRRILERVE	DEG_APCC_DBOX_1	1213:1221	Mutation rewiring degron network	0.2778
p.R1211W	639-V	urinary tract	COSMIC	LTPTVE	DEG_SCF_FBW7_2	1199:1204	Mutation rewiring degron network	0.1389
p.S1416C	TCGA-JW-A5VL	CESC	TCGA	PGTPGRE	DEG_SCF_FBW7_2	1407:1413	Mutation rewiring degron network	0.25
p.S1416C	DO49976	CESC	ICGC	PGTPGRE	DEG_SCF_FBW7_2	1407:1413	Mutation rewiring degron network	0.25
p.K1902N	TCGA-XP-A8T8	ESCA	TCGA	GMR	DEG_APCC_TPR_1	1905:1907	Mutation substituting flanking lysine	0.3611
p.R950G	DO228483	BRCA	ICGC	VQTPEGS	DEG_SCF_FBW7_1	959:965	Mutation rewiring degron network	0.0833
p.R950G	SIDM00530	Esophageal Carcinoma	GDSC	VQTPEGS	DEG_SCF_FBW7_1	959:965	Mutation rewiring degron network	0.0833
p.R950G	SIDM00568	Gastric Carcinoma	GDSC	VQTPEGS	DEG_SCF_FBW7_1	959:965	Mutation rewiring degron network	0.0833
p.R950G	SIDM00556	Neuroblastoma	GDSC	VQTPEGS	DEG_SCF_FBW7_1	959:965	Mutation rewiring degron network	0.0833
p.R950G	SIDM00817	Kidney Carcinoma	GDSC	VQTPEGS	DEG_SCF_FBW7_1	959:965	Mutation rewiring degron network	0.0833
p.R950G	ACH-000247	Gastric Cancer	CCLE	VQTPEGS	DEG_SCF_FBW7_1	959:965	Mutation rewiring degron network	0.0833
p.R950G	KP-N-YN	autonomic ganglia	COSMIC	VQTPEGS	DEG_SCF_FBW7_1	959:965	Mutation rewiring degron network	0.0833
p.R950G	OCUM-1	stomach	COSMIC	VQTPEGS	DEG_SCF_FBW7_1	959:965	Mutation rewiring degron network	0.0833
p.P1112L	DO217850	BTCA	ICGC	LGTPTQS	DEG_SCF_FBW7_1	1118:1124	Mutation rewiring degron network	0.1667
p.R1215H	DO227549	COCA	ICGC	SRRILERVE	DEG_APCC_DBOX_1	1213:1221	Mutation altering degron motif	0.7133
p.R1215H	DO233869	GACA	ICGC	SRRILERVE	DEG_APCC_DBOX_1	1213:1221	Mutation altering degron motif	0.7133
p.T761M	DO229003	COCA	ICGC	ASSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1667
p.T761M	DO229005	COCA	ICGC	ASSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1667
p.T761M	DO230659	LAML	ICGC	ASSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1667
p.T761M	DO231140	LAML	ICGC	ASSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1667
p.T761M	SIDM00450	Acute Myeloid Leukemia	GDSC	ASSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1667
p.T761M	SIDM00322	Esophageal Squamous Cell Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1667
p.T761M	SIDM00371	Pancreatic Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1667
p.T761M	SIDM00611	Kidney Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1667
p.T761M	SIDM00367	Small Cell Lung Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1667
p.T761M	SIDM00193	Colorectal Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1667
p.T761M	SIDM01144	Gastric Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1667
p.T761M	SIDM00556	Neuroblastoma	GDSC	ASSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1667
p.T761M	SIDM00358	Gastric Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1667
p.T761M	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1667
p.T761M	SIDM00024	Non-Cancerous	GDSC	ASSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1667
p.T761M	SIDM00567	Other Solid Cancers	GDSC	ASSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1667
p.T761M	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	ASSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1667
p.T761M	SIDM00807	Bladder Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1667
p.T761M	SIDM00616	Hepatocellular Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1667
p.T761M	SIDM01187	Breast Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1667
p.T761M	SIDM00241	Breast Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1667
p.T761M	SIDM00579	Neuroblastoma	GDSC	ASSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1667
p.T761M	SIDM00591	Oral Cavity Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1667
p.T761M	SIDM00604	Oral Cavity Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1667
p.T761M	SIDM00167	Head and Neck Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1667
p.T761M	SIDM00169	Head and Neck Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1667
p.T761M	SIDM01781	Gastric Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1667
p.T761M	SIDM00161	Biliary Tract Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1667
p.T761M	SIDM01447	Glioblastoma	GDSC	ASSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1667
p.T761M	SIDM01450	Gastric Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1667
p.T761M	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1667
p.G1119V	DO228126	EOPC	ICGC	LGTPTQS	DEG_SCF_FBW7_1	1118:1124	Mutation altering degron motif	0.6421
p.A767T	DO234462	ESAD	ICGC	ASSSS	DEG_SPOP_SBC_1	767:771	Mutation altering degron motif	0.7139
p.G972S	DO16999	KIRC	ICGC	VQTPEGS	DEG_SCF_FBW7_1	959:965	Mutation rewiring degron network	0.1389
p.G1117V	DO228925	LICA	ICGC	LGTPTQS	DEG_SCF_FBW7_1	1118:1124	Mutation rewiring degron network	0.3056
p.R1412W	DO228941	LICA	ICGC	PGTPGRE	DEG_SCF_FBW7_2	1407:1413	Mutation altering degron motif	0.7523
p.A664S	DO229019	LICA	ICGC	LTPQPT	DEG_SCF_FBW7_1	672:677	Mutation rewiring degron network	0.1111
p.S768I	DO229028	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	767:771	Mutation altering degron motif	0.623
p.S768I	DO229032	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	767:771	Mutation altering degron motif	0.623
p.G1408V	DO229024	LICA	ICGC	PGTPGRE	DEG_SCF_FBW7_2	1407:1413	Mutation altering degron motif	0.6421
p.R1215L	DO229026	LICA	ICGC	SRRILERVE	DEG_APCC_DBOX_1	1213:1221	Mutation altering degron motif	0.7316
p.G1905V	DO229026	LICA	ICGC	GMR	DEG_APCC_TPR_1	1905:1907	Mutation altering degron motif	0.6421
p.G777W	DO229032	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1667
p.V778F	DO229009	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1389
p.A1423E	DO26894	LUSC	ICGC	PGTPGRE	DEG_SCF_FBW7_2	1407:1413	Mutation rewiring degron network	0.0556
p.G964E	DO220903	MELA	ICGC	VQTPEGS	DEG_SCF_FBW7_1	959:965	Mutation altering degron motif	0.6087
p.S766L	DO220906	MELA	ICGC	ASSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.3056
p.P75S	DO220911	MELA	ICGC	PGSST	DEG_SPOP_SBC_1	77:81	Mutation rewiring degron network	0.2778
p.P1398L	DO222415	MELA	ICGC	PGTPGRE	DEG_SCF_FBW7_2	1407:1413	Mutation rewiring degron network	0.0833
p.R73W	DO222843	MELA	ICGC	PGSST	DEG_SPOP_SBC_1	77:81	Mutation rewiring degron network	0.2222
p.K1902R	DO232832	NACA	ICGC	GMR	DEG_APCC_TPR_1	1905:1907	Mutation substituting flanking lysine	0.3611
p.S1124R	DO33400	PACA	ICGC	LGTPTQS	DEG_SCF_FBW7_1	1118:1124	Mutation altering degron motif	0.7427
p.S1401N	DO46961	RECA	ICGC	PGTPGRE	DEG_SCF_FBW7_2	1407:1413	Mutation rewiring degron network	0.1667
p.S1401R	DO46961	RECA	ICGC	PGTPGRE	DEG_SCF_FBW7_2	1407:1413	Mutation rewiring degron network	0.1667
p.G663D	SIDM00935	Other Solid Cancers	GDSC	LTPQPT	DEG_SCF_FBW7_1	672:677	Mutation rewiring degron network	0.0833
p.G663D	SIDM00414	Bladder Carcinoma	GDSC	LTPQPT	DEG_SCF_FBW7_1	672:677	Mutation rewiring degron network	0.0833
p.G663D	SIDM00032	Bladder Carcinoma	GDSC	LTPQPT	DEG_SCF_FBW7_1	672:677	Mutation rewiring degron network	0.0833
p.R1211Q	SIDM00777	Colorectal Carcinoma	GDSC	SRRILERVE	DEG_APCC_DBOX_1	1213:1221	Mutation rewiring degron network	0.2778
p.R1211Q	SIDM00777	Colorectal Carcinoma	GDSC	LTPTVE	DEG_SCF_FBW7_2	1199:1204	Mutation rewiring degron network	0.1389
p.R1211Q	SIDM00779	Colorectal Carcinoma	GDSC	SRRILERVE	DEG_APCC_DBOX_1	1213:1221	Mutation rewiring degron network	0.2778
p.R1211Q	SIDM00779	Colorectal Carcinoma	GDSC	LTPTVE	DEG_SCF_FBW7_2	1199:1204	Mutation rewiring degron network	0.1389
p.R1211Q	NCI-H508	large intestine	COSMIC	SRRILERVE	DEG_APCC_DBOX_1	1213:1221	Mutation rewiring degron network	0.2778
p.R1211Q	NCI-H508	large intestine	COSMIC	LTPTVE	DEG_SCF_FBW7_2	1199:1204	Mutation rewiring degron network	0.1389
p.R1211Q	NCI-H716	large intestine	COSMIC	SRRILERVE	DEG_APCC_DBOX_1	1213:1221	Mutation rewiring degron network	0.2778
p.R1211Q	NCI-H716	large intestine	COSMIC	LTPTVE	DEG_SCF_FBW7_2	1199:1204	Mutation rewiring degron network	0.1389
p.R1219C	SIDM00602	Gastric Carcinoma	GDSC	SRRILERVE	DEG_APCC_DBOX_1	1213:1221	Mutation altering degron motif	0.719
p.R1219C	ACH-000919	Gastric Cancer	CCLE	SRRILERVE	DEG_APCC_DBOX_1	1213:1221	Mutation altering degron motif	0.719
p.R1219C	IM-95	stomach	COSMIC	SRRILERVE	DEG_APCC_DBOX_1	1213:1221	Mutation altering degron motif	0.719
p.S1110F	SIDM00120	Prostate Carcinoma	GDSC	LGTPTQS	DEG_SCF_FBW7_1	1118:1124	Mutation rewiring degron network	0.1111
p.S1110F	ACH-000979	Prostate Cancer	CCLE	LGTPTQS	DEG_SCF_FBW7_1	1118:1124	Mutation rewiring degron network	0.1111
p.S1110F	DU-145	prostate	COSMIC	LGTPTQS	DEG_SCF_FBW7_1	1118:1124	Mutation rewiring degron network	0.1111
p.P975S	SIDM01129	Small Cell Lung Carcinoma	GDSC	VQTPEGS	DEG_SCF_FBW7_1	959:965	Mutation rewiring degron network	0.0556
p.P975S	ACH-000816	Lung Cancer	CCLE	VQTPEGS	DEG_SCF_FBW7_1	959:965	Mutation rewiring degron network	0.0556
p.P975S	NCI-H524	lung	COSMIC	VQTPEGS	DEG_SCF_FBW7_1	959:965	Mutation rewiring degron network	0.0556
p.P1112S	SIDM00690	Head and Neck Carcinoma	GDSC	LGTPTQS	DEG_SCF_FBW7_1	1118:1124	Mutation rewiring degron network	0.1667
p.P1112S	ACH-002251	Head and Neck Cancer	CCLE	LGTPTQS	DEG_SCF_FBW7_1	1118:1124	Mutation rewiring degron network	0.1667
p.P1112S	JHU-029	upper aerodigestive tract	COSMIC	LGTPTQS	DEG_SCF_FBW7_1	1118:1124	Mutation rewiring degron network	0.1667
p.I1216F	SIDM00282	Colorectal Carcinoma	GDSC	SRRILERVE	DEG_APCC_DBOX_1	1213:1221	Mutation altering degron motif	0.6304
p.I1216F	ACH-000998	Colon/Colorectal Cancer	CCLE	SRRILERVE	DEG_APCC_DBOX_1	1213:1221	Mutation altering degron motif	0.6304
p.I1216F	CW-2	large intestine	COSMIC	SRRILERVE	DEG_APCC_DBOX_1	1213:1221	Mutation altering degron motif	0.6304
p.K970N	SIDM00806	Osteosarcoma	GDSC	VQTPEGS	DEG_SCF_FBW7_1	959:965	Mutation substituting flanking lysine	0.3056
p.K970N	SIDM00085	Glioma	GDSC	VQTPEGS	DEG_SCF_FBW7_1	959:965	Mutation substituting flanking lysine	0.3056
p.K970N	ACH-000613	Bone Cancer	CCLE	VQTPEGS	DEG_SCF_FBW7_1	959:965	Mutation substituting flanking lysine	0.3056
p.K970N	ACH-001001	Bone Cancer	CCLE	VQTPEGS	DEG_SCF_FBW7_1	959:965	Mutation substituting flanking lysine	0.3056
p.K970N	ACH-001094	Myeloma	CCLE	VQTPEGS	DEG_SCF_FBW7_1	959:965	Mutation substituting flanking lysine	0.3056
p.K970N	HOS	bone	COSMIC	VQTPEGS	DEG_SCF_FBW7_1	959:965	Mutation substituting flanking lysine	0.3056
p.L1217M	SIDM00675	Breast Carcinoma	GDSC	SRRILERVE	DEG_APCC_DBOX_1	1213:1221	Mutation altering degron motif	0.711
p.L1217M	ACH-000276	Breast Cancer	CCLE	SRRILERVE	DEG_APCC_DBOX_1	1213:1221	Mutation altering degron motif	0.711
p.L1217M	HCC38	breast	COSMIC	SRRILERVE	DEG_APCC_DBOX_1	1213:1221	Mutation altering degron motif	0.711
p.T81M	SIDM01067	Non-Small Cell Lung Carcinoma	GDSC	PGSST	DEG_SPOP_SBC_1	77:81	Mutation altering degron motif	0.7423
p.E1128K	SIDM00528	Breast Carcinoma	GDSC	LGTPTQS	DEG_SCF_FBW7_1	1118:1124	Mutation rewiring degron network	0.2222
p.E1128K	ACH-000934	Breast Cancer	CCLE	LGTPTQS	DEG_SCF_FBW7_1	1118:1124	Mutation rewiring degron network	0.2222
p.E1128K	MDA-MB-361	breast	COSMIC	LGTPTQS	DEG_SCF_FBW7_1	1118:1124	Mutation rewiring degron network	0.2222
p.P952H	SIDM01609	Endometrial Carcinoma	GDSC	VQTPEGS	DEG_SCF_FBW7_1	959:965	Mutation rewiring degron network	0.1389
p.P952H	ACH-000972	Endometrial/Uterine Cancer	CCLE	VQTPEGS	DEG_SCF_FBW7_1	959:965	Mutation rewiring degron network	0.1389
p.S1196P	ACH-000153	Lung Cancer	CCLE	LTPTVE	DEG_SCF_FBW7_2	1199:1204	Mutation rewiring degron network	0.25
p.Q667K	ACH-001194	Kidney Cancer	CCLE	LTPQPT	DEG_SCF_FBW7_1	672:677	Mutation rewiring degron network	0.1944
p.S1901F	ACH-001395	Breast Cancer	CCLE	GMR	DEG_APCC_TPR_1	1905:1907	Mutation rewiring degron network	0.2222
p.R1215C	ACH-001456	Colon/Colorectal Cancer	CCLE	SRRILERVE	DEG_APCC_DBOX_1	1213:1221	Mutation altering degron motif	0.719

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ALPK3

UniProt ID: Q96L96

Entrez ID: 57538

Protein name: Alpha-protein kinase 3 (EC 2.7.11.1) (Muscle alpha-protein kinase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ALPK3 in