DegronMD

Uniprot ID: Q96L96

Source protein: Alpha-protein kinase 3

Source gene: ALPK3

Class: DEG_SCF_FBW7_1

Location: 959:965

E3 ligase: FBXW7

DEGRON score: 0.7113

ASA_SCORE: 93.3429

COIL: 0.9339

CONS_SCORE: 0.4111

DSS_SCORE: 0.3055

HELIX: 0.0166

FCONS_SCORE: 1.1676

RIG_SCORE: 0.736

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E956D	TCGA-A5-A0G1	UCEC	TCGA	VQTPEGS	DEG_SCF_FBW7_1	0.25
p.E956D	DO42472	UCEC	ICGC	VQTPEGS	DEG_SCF_FBW7_1	0.25
p.I955V	TCGA-BG-A0VT	UCEC	TCGA	VQTPEGS	DEG_SCF_FBW7_1	0.2222
p.I955V	DO41935	UCEC	ICGC	VQTPEGS	DEG_SCF_FBW7_1	0.2222
p.P949L	TCGA-FS-A1ZK	SKCM	TCGA	VQTPEGS	DEG_SCF_FBW7_1	0.0556
p.P949L	DO37474	SKCM	ICGC	VQTPEGS	DEG_SCF_FBW7_1	0.0556
p.R950G	DO228483	BRCA	ICGC	VQTPEGS	DEG_SCF_FBW7_1	0.0833
p.R950G	SIDM00530	Esophageal Carcinoma	GDSC	VQTPEGS	DEG_SCF_FBW7_1	0.0833
p.R950G	SIDM00568	Gastric Carcinoma	GDSC	VQTPEGS	DEG_SCF_FBW7_1	0.0833
p.R950G	SIDM00556	Neuroblastoma	GDSC	VQTPEGS	DEG_SCF_FBW7_1	0.0833
p.R950G	SIDM00817	Kidney Carcinoma	GDSC	VQTPEGS	DEG_SCF_FBW7_1	0.0833
p.R950G	ACH-000247	Gastric Cancer	CCLE	VQTPEGS	DEG_SCF_FBW7_1	0.0833
p.R950G	KP-N-YN	autonomic_ganglia	COSMIC	VQTPEGS	DEG_SCF_FBW7_1	0.0833
p.R950G	OCUM-1	stomach	COSMIC	VQTPEGS	DEG_SCF_FBW7_1	0.0833
p.G972S	DO16999	KIRC	ICGC	VQTPEGS	DEG_SCF_FBW7_1	0.1389
p.G964E	DO220903	MELA	ICGC	VQTPEGS	DEG_SCF_FBW7_1	0.6087
p.P975S	SIDM01129	Small Cell Lung Carcinoma	GDSC	VQTPEGS	DEG_SCF_FBW7_1	0.0556
p.P975S	ACH-000816	Lung Cancer	CCLE	VQTPEGS	DEG_SCF_FBW7_1	0.0556
p.P975S	NCI-H524	lung	COSMIC	VQTPEGS	DEG_SCF_FBW7_1	0.0556
p.K970N	SIDM00806	Osteosarcoma	GDSC	VQTPEGS	DEG_SCF_FBW7_1	0.3056
p.K970N	SIDM00085	Glioma	GDSC	VQTPEGS	DEG_SCF_FBW7_1	0.3056
p.K970N	ACH-000613	Bone Cancer	CCLE	VQTPEGS	DEG_SCF_FBW7_1	0.3056
p.K970N	ACH-001001	Bone Cancer	CCLE	VQTPEGS	DEG_SCF_FBW7_1	0.3056
p.K970N	ACH-001094	Myeloma	CCLE	VQTPEGS	DEG_SCF_FBW7_1	0.3056
p.K970N	HOS	bone	COSMIC	VQTPEGS	DEG_SCF_FBW7_1	0.3056
p.P952H	SIDM01609	Endometrial Carcinoma	GDSC	VQTPEGS	DEG_SCF_FBW7_1	0.1389
p.P952H	ACH-000972	Endometrial/Uterine Cancer	CCLE	VQTPEGS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96L96	Alpha-protein kinase 3	DEG_SCF_FBW7_1	959:965	VQTPEGS	FBXW7	0.7113	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VQTPEGS

Degron related mutations and impact score

Drug responses associated with ALPK3 mutations

All proteins holding degron of VQTPEGS