DegronMD

Uniprot ID: Q96L96

Source protein: Alpha-protein kinase 3

Source gene: ALPK3

Class: DEG_APCC_DBOX_1

Location: 1213:1221

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.913

ASA_SCORE: 117.0333

COIL: 0.819

CONS_SCORE: 0.6272

DSS_SCORE: 0.4199

HELIX: 0.098

FCONS_SCORE: 0.9937

RIG_SCORE: 0.7958

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1213L	TCGA-A5-A0G2	UCEC	TCGA	SRRILERVE	DEG_APCC_DBOX_1	0.6556
p.S1213L	TCGA-AX-A2HC	UCEC	TCGA	SRRILERVE	DEG_APCC_DBOX_1	0.6556
p.S1213L	DO222662	MELA	ICGC	SRRILERVE	DEG_APCC_DBOX_1	0.6556
p.S1213L	DO41572	UCEC	ICGC	SRRILERVE	DEG_APCC_DBOX_1	0.6556
p.S1213L	DO41235	UCEC	ICGC	SRRILERVE	DEG_APCC_DBOX_1	0.6556
p.Q1227H	TCGA-D3-A3C7	SKCM	TCGA	SRRILERVE	DEG_APCC_DBOX_1	0.1667
p.Q1227H	TCGA-DS-A1OB	CESC	TCGA	SRRILERVE	DEG_APCC_DBOX_1	0.1667
p.Q1227H	DO6323	CESC	ICGC	SRRILERVE	DEG_APCC_DBOX_1	0.1667
p.Q1227H	DO233702	GACA	ICGC	SRRILERVE	DEG_APCC_DBOX_1	0.1667
p.Q1227H	DO47569	SKCM	ICGC	SRRILERVE	DEG_APCC_DBOX_1	0.1667
p.R1211W	TCGA-HU-A4H3	STAD	TCGA	SRRILERVE	DEG_APCC_DBOX_1	0.2778
p.R1211W	DO47903	STAD	ICGC	SRRILERVE	DEG_APCC_DBOX_1	0.2778
p.R1211W	SIDM00999	Bladder Carcinoma	GDSC	SRRILERVE	DEG_APCC_DBOX_1	0.2778
p.R1211W	ACH-000973	Bladder Cancer	CCLE	SRRILERVE	DEG_APCC_DBOX_1	0.2778
p.R1211W	639-V	urinary_tract	COSMIC	SRRILERVE	DEG_APCC_DBOX_1	0.2778
p.R1215H	DO227549	COCA	ICGC	SRRILERVE	DEG_APCC_DBOX_1	0.7133
p.R1215H	DO233869	GACA	ICGC	SRRILERVE	DEG_APCC_DBOX_1	0.7133
p.R1215L	DO229026	LICA	ICGC	SRRILERVE	DEG_APCC_DBOX_1	0.7316
p.R1211Q	SIDM00777	Colorectal Carcinoma	GDSC	SRRILERVE	DEG_APCC_DBOX_1	0.2778
p.R1211Q	SIDM00779	Colorectal Carcinoma	GDSC	SRRILERVE	DEG_APCC_DBOX_1	0.2778
p.R1211Q	NCI-H508	large_intestine	COSMIC	SRRILERVE	DEG_APCC_DBOX_1	0.2778
p.R1211Q	NCI-H716	large_intestine	COSMIC	SRRILERVE	DEG_APCC_DBOX_1	0.2778
p.R1219C	SIDM00602	Gastric Carcinoma	GDSC	SRRILERVE	DEG_APCC_DBOX_1	0.719
p.R1219C	ACH-000919	Gastric Cancer	CCLE	SRRILERVE	DEG_APCC_DBOX_1	0.719
p.R1219C	IM-95	stomach	COSMIC	SRRILERVE	DEG_APCC_DBOX_1	0.719
p.I1216F	SIDM00282	Colorectal Carcinoma	GDSC	SRRILERVE	DEG_APCC_DBOX_1	0.6304
p.I1216F	ACH-000998	Colon/Colorectal Cancer	CCLE	SRRILERVE	DEG_APCC_DBOX_1	0.6304
p.I1216F	CW-2	large_intestine	COSMIC	SRRILERVE	DEG_APCC_DBOX_1	0.6304
p.L1217M	SIDM00675	Breast Carcinoma	GDSC	SRRILERVE	DEG_APCC_DBOX_1	0.711
p.L1217M	ACH-000276	Breast Cancer	CCLE	SRRILERVE	DEG_APCC_DBOX_1	0.711
p.L1217M	HCC38	breast	COSMIC	SRRILERVE	DEG_APCC_DBOX_1	0.711
p.R1215C	ACH-001456	Colon/Colorectal Cancer	CCLE	SRRILERVE	DEG_APCC_DBOX_1	0.719

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SRRILERVE

Degron related mutations and impact score

Drug responses associated with ALPK3 mutations

All proteins holding degron of SRRILERVE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96L96	Alpha-protein kinase 3	DEG_APCC_DBOX_1	1213:1221	SRRILERVE	APC,CDC20,FZR1	0.913	More...