DegronMD

Uniprot ID: Q96L96

Source protein: Alpha-protein kinase 3

Source gene: ALPK3

Class: DEG_SCF_FBW7_1

Location: 1118:1124

E3 ligase: FBXW7

DEGRON score: 0.9002

ASA_SCORE: 87.7

COIL: 0.9373

CONS_SCORE: 0.4942

DSS_SCORE: 0.6985

HELIX: 0.023

FCONS_SCORE: 0.9899

RIG_SCORE: 0.5841

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H1125Q	TCGA-18-3416	LUSC	TCGA	LGTPTQS	DEG_SCF_FBW7_1	0.3056
p.H1125Q	DO26423	LUSC	ICGC	LGTPTQS	DEG_SCF_FBW7_1	0.3056
p.T1113I	TCGA-58-A46J	LUSC	TCGA	LGTPTQS	DEG_SCF_FBW7_1	0.1944
p.T1113I	DO231141	LUSC	ICGC	LGTPTQS	DEG_SCF_FBW7_1	0.1944
p.T1113I	DO45532	LUSC	ICGC	LGTPTQS	DEG_SCF_FBW7_1	0.1944
p.P1112T	TCGA-FS-A1ZR	SKCM	TCGA	LGTPTQS	DEG_SCF_FBW7_1	0.1667
p.P1112T	DO37651	SKCM	ICGC	LGTPTQS	DEG_SCF_FBW7_1	0.1667
p.P1112L	DO217850	BTCA	ICGC	LGTPTQS	DEG_SCF_FBW7_1	0.1667
p.G1119V	DO228126	EOPC	ICGC	LGTPTQS	DEG_SCF_FBW7_1	0.6421
p.G1117V	DO228925	LICA	ICGC	LGTPTQS	DEG_SCF_FBW7_1	0.3056
p.S1124R	DO33400	PACA	ICGC	LGTPTQS	DEG_SCF_FBW7_1	0.7427
p.S1110F	SIDM00120	Prostate Carcinoma	GDSC	LGTPTQS	DEG_SCF_FBW7_1	0.1111
p.S1110F	ACH-000979	Prostate Cancer	CCLE	LGTPTQS	DEG_SCF_FBW7_1	0.1111
p.S1110F	DU-145	prostate	COSMIC	LGTPTQS	DEG_SCF_FBW7_1	0.1111
p.P1112S	SIDM00690	Head and Neck Carcinoma	GDSC	LGTPTQS	DEG_SCF_FBW7_1	0.1667
p.P1112S	ACH-002251	Head and Neck Cancer	CCLE	LGTPTQS	DEG_SCF_FBW7_1	0.1667
p.P1112S	JHU-029	upper_aerodigestive_tract	COSMIC	LGTPTQS	DEG_SCF_FBW7_1	0.1667
p.E1128K	SIDM00528	Breast Carcinoma	GDSC	LGTPTQS	DEG_SCF_FBW7_1	0.2222
p.E1128K	ACH-000934	Breast Cancer	CCLE	LGTPTQS	DEG_SCF_FBW7_1	0.2222
p.E1128K	MDA-MB-361	breast	COSMIC	LGTPTQS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96L96	Alpha-protein kinase 3	DEG_SCF_FBW7_1	1118:1124	LGTPTQS	FBXW7	0.9002	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons