DegronMD

Uniprot ID: Q96L96

Source protein: Alpha-protein kinase 3

Source gene: ALPK3

Class: DEG_SCF_FBW7_2

Location: 1407:1413

E3 ligase: FBXW7

DEGRON score: 0.9691

ASA_SCORE: 99.6429

COIL: 0.9471

CONS_SCORE: 0.4586

DSS_SCORE: 0.862

HELIX: 0.0231

FCONS_SCORE: 0.8722

RIG_SCORE: 0.5001

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1415C	TCGA-G4-6586	COAD	TCGA	PGTPGRE	DEG_SCF_FBW7_2	0.2778
p.R1415C	DO9698	COAD	ICGC	PGTPGRE	DEG_SCF_FBW7_2	0.2778
p.S1416C	TCGA-JW-A5VL	CESC	TCGA	PGTPGRE	DEG_SCF_FBW7_2	0.25
p.S1416C	DO49976	CESC	ICGC	PGTPGRE	DEG_SCF_FBW7_2	0.25
p.R1412W	DO228941	LICA	ICGC	PGTPGRE	DEG_SCF_FBW7_2	0.7523
p.G1408V	DO229024	LICA	ICGC	PGTPGRE	DEG_SCF_FBW7_2	0.6421
p.A1423E	DO26894	LUSC	ICGC	PGTPGRE	DEG_SCF_FBW7_2	0.0556
p.P1398L	DO222415	MELA	ICGC	PGTPGRE	DEG_SCF_FBW7_2	0.0833
p.S1401N	DO46961	RECA	ICGC	PGTPGRE	DEG_SCF_FBW7_2	0.1667
p.S1401R	DO46961	RECA	ICGC	PGTPGRE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96L96	Alpha-protein kinase 3	DEG_SCF_FBW7_2	1407:1413	PGTPGRE	FBXW7	0.9691	More...
Q9C0C7	Activating molecule in BECN1-regulated autophagy protein 1	DEG_SCF_FBW7_2	1236:1242	PGTPGRE	FBXW7	0.959	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons