DegronMD

Uniprot ID: Q9C0C7

Source protein: Activating molecule in BECN1-regulated autophagy protein 1

Source gene: AMBRA1

Class: DEG_SCF_FBW7_2

Location: 1236:1242

E3 ligase: FBXW7

DEGRON score: 0.959

ASA_SCORE: 86.4857

COIL: 0.9209

CONS_SCORE: 0.3282

DSS_SCORE: 0.8374

HELIX: 0.0221

FCONS_SCORE: 1.0103

RIG_SCORE: 0.5343

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N1237Y	SIDM00659	Glioblastoma	GDSC	PGTPGRE	DEG_SCF_FBW7_2	0.7059
p.N1237Y	M059J	central_nervous_system	COSMIC	PGTPGRE	DEG_SCF_FBW7_2	0.7059
p.R1232M	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PGTPGRE	DEG_SCF_FBW7_2	0.2222
p.R1232M	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PGTPGRE	DEG_SCF_FBW7_2	0.2222
p.E1235G	SW1271	lung	COSMIC	PGTPGRE	DEG_SCF_FBW7_2	0.3056
p.T1238A	HT	haematopoietic_and_lymphoid_tissue	COSMIC	PGTPGRE	DEG_SCF_FBW7_2	0.825
p.P1226L	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PGTPGRE	DEG_SCF_FBW7_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96L96	Alpha-protein kinase 3	DEG_SCF_FBW7_2	1407:1413	PGTPGRE	FBXW7	0.9691	More...
Q9C0C7	Activating molecule in BECN1-regulated autophagy protein 1	DEG_SCF_FBW7_2	1236:1242	PGTPGRE	FBXW7	0.959	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons