DegronMD

Uniprot ID: Q96L96

Source protein: Alpha-protein kinase 3

Source gene: ALPK3

Class: DEG_APCC_TPR_1

Location: 1905:1907

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9603

ASA_SCORE: 130.6333

COIL: 0.9133

CONS_SCORE: 0.4133

DSS_SCORE: 0.9869

HELIX: 0.0853

FCONS_SCORE: 1.1128

RIG_SCORE: 0.6437

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1907W	TCGA-AX-A1CE	UCEC	TCGA	GMR	DEG_APCC_TPR_1	0.8634
p.R1907W	DO42280	UCEC	ICGC	GMR	DEG_APCC_TPR_1	0.8634
p.R1907W	ACH-001518	Endometrial/Uterine Cancer	CCLE	GMR	DEG_APCC_TPR_1	0.8634
p.Q1904K	TCGA-E8-A2EA	THCA	TCGA	GMR	DEG_APCC_TPR_1	0.3056
p.Q1904K	DO38926	THCA	ICGC	GMR	DEG_APCC_TPR_1	0.3056
p.G1905S	TCGA-FS-A1ZW	SKCM	TCGA	GMR	DEG_APCC_TPR_1	0.5882
p.G1905S	DO37519	SKCM	ICGC	GMR	DEG_APCC_TPR_1	0.5882
p.K1902N	TCGA-XP-A8T8	ESCA	TCGA	GMR	DEG_APCC_TPR_1	0.3611
p.G1905V	DO229026	LICA	ICGC	GMR	DEG_APCC_TPR_1	0.6421
p.K1902R	DO232832	NACA	ICGC	GMR	DEG_APCC_TPR_1	0.3611
p.S1901F	ACH-001395	Breast Cancer	CCLE	GMR	DEG_APCC_TPR_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51955	Serine/threonine-protein kinase Nek2	DEG_APCC_TPR_1	443:445	GMR	APC,CDC20,FZR1	0.9984	More...
Q96L96	Alpha-protein kinase 3	DEG_APCC_TPR_1	1905:1907	GMR	APC,CDC20,FZR1	0.9603	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons