DegronMD

Uniprot ID: Q96L96

Source protein: Alpha-protein kinase 3

Source gene: ALPK3

Class: DEG_SCF_FBW7_1

Location: 672:677

E3 ligase: FBXW7

DEGRON score: 0.7071

ASA_SCORE: 100.25

COIL: 0.9622

CONS_SCORE: 0.4879

DSS_SCORE: 0.8589

HELIX: 0.0135

FCONS_SCORE: 0.9173

RIG_SCORE: 0.6047

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H670D	TCGA-43-5668	LUSC	TCGA	LTPQPT	DEG_SCF_FBW7_1	0.2778
p.H670D	DO26608	LUSC	ICGC	LTPQPT	DEG_SCF_FBW7_1	0.2778
p.K683N	TCGA-85-8351	LUSC	TCGA	LTPQPT	DEG_SCF_FBW7_1	0.2778
p.K683N	DO45447	LUSC	ICGC	LTPQPT	DEG_SCF_FBW7_1	0.2778
p.P687H	TCGA-AP-A051	UCEC	TCGA	LTPQPT	DEG_SCF_FBW7_1	0.0556
p.P687H	DO42673	UCEC	ICGC	LTPQPT	DEG_SCF_FBW7_1	0.0556
p.A664T	TCGA-BS-A0UV	UCEC	TCGA	LTPQPT	DEG_SCF_FBW7_1	0.1111
p.A664T	DO42793	UCEC	ICGC	LTPQPT	DEG_SCF_FBW7_1	0.1111
p.T669I	TCGA-CD-A4MJ	STAD	TCGA	LTPQPT	DEG_SCF_FBW7_1	0.25
p.T669I	DO47811	STAD	ICGC	LTPQPT	DEG_SCF_FBW7_1	0.25
p.P687S	TCGA-D9-A6EC	SKCM	TCGA	LTPQPT	DEG_SCF_FBW7_1	0.0556
p.P687S	DO50291	SKCM	ICGC	LTPQPT	DEG_SCF_FBW7_1	0.0556
p.R682I	TCGA-FS-A1Z0	SKCM	TCGA	LTPQPT	DEG_SCF_FBW7_1	0.1944
p.R682I	DO37431	SKCM	ICGC	LTPQPT	DEG_SCF_FBW7_1	0.1944
p.A664S	DO229019	LICA	ICGC	LTPQPT	DEG_SCF_FBW7_1	0.1111
p.G663D	SIDM00935	Other Solid Cancers	GDSC	LTPQPT	DEG_SCF_FBW7_1	0.0833
p.G663D	SIDM00414	Bladder Carcinoma	GDSC	LTPQPT	DEG_SCF_FBW7_1	0.0833
p.G663D	SIDM00032	Bladder Carcinoma	GDSC	LTPQPT	DEG_SCF_FBW7_1	0.0833
p.Q667K	ACH-001194	Kidney Cancer	CCLE	LTPQPT	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96JP9	Cadherin-related family member 1	DEG_SCF_FBW7_1	818:823	LTPQPT	FBXW7	0.946	More...
Q96L96	Alpha-protein kinase 3	DEG_SCF_FBW7_1	672:677	LTPQPT	FBXW7	0.7071	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons