DegronMD

Uniprot ID: Q96JP9

Source protein: Cadherin-related family member 1

Source gene: CDHR1

Class: DEG_SCF_FBW7_1

Location: 818:823

E3 ligase: FBXW7

DEGRON score: 0.946

ASA_SCORE: 79.65

COIL: 0.8793

CONS_SCORE: 0.576

DSS_SCORE: 0.7481

HELIX: 0.0348

FCONS_SCORE: 0.9578

RIG_SCORE: 0.5837

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G833R	TCGA-21-1079	LUSC	TCGA	LTPQPT	DEG_SCF_FBW7_1	0.0556
p.G833R	DO26846	LUSC	ICGC	LTPQPT	DEG_SCF_FBW7_1	0.0556
p.V814I	TCGA-B5-A3FC	UCEC	TCGA	LTPQPT	DEG_SCF_FBW7_1	0.2222
p.V814I	TCGA-CQ-7064	HNSC	TCGA	LTPQPT	DEG_SCF_FBW7_1	0.2222
p.P820L	TCGA-D1-A103	UCEC	TCGA	LTPQPT	DEG_SCF_FBW7_1	0.7582
p.P820L	DO42312	UCEC	ICGC	LTPQPT	DEG_SCF_FBW7_1	0.7582
p.V811M	TCGA-DX-A8BM	SARC	TCGA	LTPQPT	DEG_SCF_FBW7_1	0.1389
p.T831I	TCGA-EE-A20C	SKCM	TCGA	LTPQPT	DEG_SCF_FBW7_1	0.1111
p.T831I	DO222775	MELA	ICGC	LTPQPT	DEG_SCF_FBW7_1	0.1111
p.T831I	DO47665	SKCM	ICGC	LTPQPT	DEG_SCF_FBW7_1	0.1111
p.T810N	TCGA-VS-A9V1	CESC	TCGA	LTPQPT	DEG_SCF_FBW7_1	0.1111
p.T810N	DO51648	CESC	ICGC	LTPQPT	DEG_SCF_FBW7_1	0.1111
p.P812S	DO234285	ESAD	ICGC	LTPQPT	DEG_SCF_FBW7_1	0.1667
p.P820S	DO222843	MELA	ICGC	LTPQPT	DEG_SCF_FBW7_1	0.6752
p.S817F	SIDM00252	Biliary Tract Carcinoma	GDSC	LTPQPT	DEG_SCF_FBW7_1	0.3056
p.S817F	TGBC1TKB	biliary_tract	COSMIC	LTPQPT	DEG_SCF_FBW7_1	0.3056
p.P825T	SIDM01596	Non-Small Cell Lung Carcinoma	GDSC	LTPQPT	DEG_SCF_FBW7_1	0.2778
p.W809S	ACH-002004	Skin Cancer	CCLE	LTPQPT	DEG_SCF_FBW7_1	0.0833
p.T819S	ACH-002024	Colon/Colorectal Cancer	CCLE	LTPQPT	DEG_SCF_FBW7_1	0.7116

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96JP9	Cadherin-related family member 1	DEG_SCF_FBW7_1	818:823	LTPQPT	FBXW7	0.946	More...
Q96L96	Alpha-protein kinase 3	DEG_SCF_FBW7_1	672:677	LTPQPT	FBXW7	0.7071	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons