DegronMD - Q96JP9(CDHR1)

FUNCTION: Potential calcium-dependent cell-adhesion protein. May be required for the structural integrity of the outer segment (OS) of photoreceptor cells (By similarity). {ECO:0000250}.

GO - Biological processes (BP): cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; photoreceptor cell maintenance [GO:0045494]; photoreceptor cell morphogenesis [GO:0008594]; photoreceptor cell outer segment organization [GO:0035845]

GO - Molecular function (MF): calcium ion binding [GO:0005509]

GO - Cellular component (CC): integral component of plasma membrane [GO:0005887]; photoreceptor outer segment membrane [GO:0042622]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P820L	TCGA-D1-A103	UCEC	TCGA	LTPQPT	DEG_SCF_FBW7_1	818:823	Mutation altering degron motif	0.7582
p.P820L	DO42312	UCEC	ICGC	LTPQPT	DEG_SCF_FBW7_1	818:823	Mutation altering degron motif	0.7582
p.P49L	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PEDTPVGS	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.7582
p.P49L	ACH-000983	Leukemia	CCLE	PEDTPVGS	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.7582
p.P49L	KCL-22	haematopoietic and lymphoid tissue	COSMIC	PEDTPVGS	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.7582
p.T819S	ACH-002024	Colon/Colorectal Cancer	CCLE	LTPQPT	DEG_SCF_FBW7_1	818:823	Mutation altering degron motif	0.7116
p.T48I	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PEDTPVGS	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.7078
p.T48I	ACH-000983	Leukemia	CCLE	PEDTPVGS	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.7078
p.T48I	KCL-22	haematopoietic and lymphoid tissue	COSMIC	PEDTPVGS	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.7078
p.P820S	DO222843	MELA	ICGC	LTPQPT	DEG_SCF_FBW7_1	818:823	Mutation altering degron motif	0.6752
p.V50I	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PEDTPVGS	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.5965
p.V50I	KCL-22	haematopoietic and lymphoid tissue	COSMIC	PEDTPVGS	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.5965
p.V50A	TCGA-BC-A10R	LIHC	TCGA	PEDTPVGS	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.5825
p.V50A	DO22962	LIHC	ICGC	PEDTPVGS	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.5825
p.D47N	DO222382	MELA	ICGC	PEDTPVGS	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.5821
p.S817F	SIDM00252	Biliary Tract Carcinoma	GDSC	LTPQPT	DEG_SCF_FBW7_1	818:823	Mutation rewiring degron network	0.3056
p.S817F	TGBC1TKB	biliary tract	COSMIC	LTPQPT	DEG_SCF_FBW7_1	818:823	Mutation rewiring degron network	0.3056
p.P825T	SIDM01596	Non-Small Cell Lung Carcinoma	GDSC	LTPQPT	DEG_SCF_FBW7_1	818:823	Mutation rewiring degron network	0.2778
p.F42L	TCGA-GC-A4ZW	BLCA	TCGA	PEDTPVGS	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.25
p.F42L	DO219024	BLCA	ICGC	PEDTPVGS	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.25

Showing 1 to 20 of 43 entries

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No resistance data available for this Degron.

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDHR1

UniProt ID: Q96JP9

Entrez ID: 92211

Protein name: Cadherin-related family member 1 (Photoreceptor cadherin) (prCAD) (Protocadherin-21)

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for CDHR1 in