DegronMD - Q96JP9(CDHR1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G833R	TCGA-21-1079	LUSC	TCGA	LTPQPT	DEG_SCF_FBW7_1	818:823	Mutation rewiring degron network	0.0556
p.G833R	DO26846	LUSC	ICGC	LTPQPT	DEG_SCF_FBW7_1	818:823	Mutation rewiring degron network	0.0556
p.M39I	TCGA-A5-A0G2	UCEC	TCGA	PEDTPVGS	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.1667
p.M39I	DO41235	UCEC	ICGC	PEDTPVGS	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.1667
p.V814I	TCGA-B5-A3FC	UCEC	TCGA	LTPQPT	DEG_SCF_FBW7_1	818:823	Mutation rewiring degron network	0.2222
p.V814I	TCGA-CQ-7064	HNSC	TCGA	LTPQPT	DEG_SCF_FBW7_1	818:823	Mutation rewiring degron network	0.2222
p.V50A	TCGA-BC-A10R	LIHC	TCGA	PEDTPVGS	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.5825
p.V50A	DO22962	LIHC	ICGC	PEDTPVGS	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.5825
p.P820L	TCGA-D1-A103	UCEC	TCGA	LTPQPT	DEG_SCF_FBW7_1	818:823	Mutation altering degron motif	0.7582
p.P820L	DO42312	UCEC	ICGC	LTPQPT	DEG_SCF_FBW7_1	818:823	Mutation altering degron motif	0.7582
p.V811M	TCGA-DX-A8BM	SARC	TCGA	LTPQPT	DEG_SCF_FBW7_1	818:823	Mutation rewiring degron network	0.1389
p.T831I	TCGA-EE-A20C	SKCM	TCGA	LTPQPT	DEG_SCF_FBW7_1	818:823	Mutation rewiring degron network	0.1111
p.T831I	DO222775	MELA	ICGC	LTPQPT	DEG_SCF_FBW7_1	818:823	Mutation rewiring degron network	0.1111
p.T831I	DO47665	SKCM	ICGC	LTPQPT	DEG_SCF_FBW7_1	818:823	Mutation rewiring degron network	0.1111
p.F42L	TCGA-GC-A4ZW	BLCA	TCGA	PEDTPVGS	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.25
p.F42L	DO219024	BLCA	ICGC	PEDTPVGS	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.25
p.T810N	TCGA-VS-A9V1	CESC	TCGA	LTPQPT	DEG_SCF_FBW7_1	818:823	Mutation rewiring degron network	0.1111
p.T810N	DO51648	CESC	ICGC	LTPQPT	DEG_SCF_FBW7_1	818:823	Mutation rewiring degron network	0.1111
p.P812S	DO234285	ESAD	ICGC	LTPQPT	DEG_SCF_FBW7_1	818:823	Mutation rewiring degron network	0.1667
p.D47N	DO222382	MELA	ICGC	PEDTPVGS	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.5821
p.P820S	DO222843	MELA	ICGC	LTPQPT	DEG_SCF_FBW7_1	818:823	Mutation altering degron motif	0.6752
p.P49L	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PEDTPVGS	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.7582
p.P49L	ACH-000983	Leukemia	CCLE	PEDTPVGS	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.7582
p.P49L	KCL-22	haematopoietic and lymphoid tissue	COSMIC	PEDTPVGS	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.7582
p.A40T	SIDM00376	B-Lymphoblastic Leukemia	GDSC	PEDTPVGS	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.1944
p.A40T	SIDM00417	Plasma Cell Myeloma	GDSC	PEDTPVGS	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.1944
p.V50I	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PEDTPVGS	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.5965
p.V50I	KCL-22	haematopoietic and lymphoid tissue	COSMIC	PEDTPVGS	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.5965
p.T48I	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PEDTPVGS	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.7078
p.T48I	ACH-000983	Leukemia	CCLE	PEDTPVGS	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.7078
p.T48I	KCL-22	haematopoietic and lymphoid tissue	COSMIC	PEDTPVGS	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.7078
p.S817F	SIDM00252	Biliary Tract Carcinoma	GDSC	LTPQPT	DEG_SCF_FBW7_1	818:823	Mutation rewiring degron network	0.3056
p.S817F	TGBC1TKB	biliary tract	COSMIC	LTPQPT	DEG_SCF_FBW7_1	818:823	Mutation rewiring degron network	0.3056
p.N36D	SIDM01018	Hodgkin's Lymphoma	GDSC	PEDTPVGS	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.0833
p.N36D	ACH-000815	Lymphoma	CCLE	PEDTPVGS	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.0833
p.N36D	ACH-001524	Skin Cancer	CCLE	PEDTPVGS	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.0833
p.N36D	ACH-001664	Gastric Cancer	CCLE	PEDTPVGS	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.0833
p.N36D	KM-H2	haematopoietic and lymphoid tissue	COSMIC	PEDTPVGS	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.0833
p.P825T	SIDM01596	Non-Small Cell Lung Carcinoma	GDSC	LTPQPT	DEG_SCF_FBW7_1	818:823	Mutation rewiring degron network	0.2778
p.G37R	SIDM01618	B-Lymphoblastic Leukemia	GDSC	PEDTPVGS	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.1111
p.G37R	ACH-000942	Leukemia	CCLE	PEDTPVGS	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.1111
p.W809S	ACH-002004	Skin Cancer	CCLE	LTPQPT	DEG_SCF_FBW7_1	818:823	Mutation rewiring degron network	0.0833
p.T819S	ACH-002024	Colon/Colorectal Cancer	CCLE	LTPQPT	DEG_SCF_FBW7_1	818:823	Mutation altering degron motif	0.7116

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDHR1

UniProt ID: Q96JP9

Entrez ID: 92211

Protein name: Cadherin-related family member 1 (Photoreceptor cadherin) (prCAD) (Protocadherin-21)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDHR1 in