DegronMD

Uniprot ID: Q96JP9

Source protein: Cadherin-related family member 1

Source gene: CDHR1

Class: DEG_SCF_FBW7_1

Location: 45:52

E3 ligase: FBXW7

DEGRON score: 0.76

ASA_SCORE: 51.6875

COIL: 0.8906

CONS_SCORE: 0.8844

DSS_SCORE: 0.3662

HELIX: 0.0086

FCONS_SCORE: 0.9765

RIG_SCORE: 0.7106

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M39I	TCGA-A5-A0G2	UCEC	TCGA	PEDTPVGS	DEG_SCF_FBW7_1	0.1667
p.M39I	DO41235	UCEC	ICGC	PEDTPVGS	DEG_SCF_FBW7_1	0.1667
p.V50A	TCGA-BC-A10R	LIHC	TCGA	PEDTPVGS	DEG_SCF_FBW7_1	0.5825
p.V50A	DO22962	LIHC	ICGC	PEDTPVGS	DEG_SCF_FBW7_1	0.5825
p.F42L	TCGA-GC-A4ZW	BLCA	TCGA	PEDTPVGS	DEG_SCF_FBW7_1	0.25
p.F42L	DO219024	BLCA	ICGC	PEDTPVGS	DEG_SCF_FBW7_1	0.25
p.D47N	DO222382	MELA	ICGC	PEDTPVGS	DEG_SCF_FBW7_1	0.5821
p.P49L	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PEDTPVGS	DEG_SCF_FBW7_1	0.7582
p.P49L	ACH-000983	Leukemia	CCLE	PEDTPVGS	DEG_SCF_FBW7_1	0.7582
p.P49L	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	PEDTPVGS	DEG_SCF_FBW7_1	0.7582
p.A40T	SIDM00376	B-Lymphoblastic Leukemia	GDSC	PEDTPVGS	DEG_SCF_FBW7_1	0.1944
p.A40T	SIDM00417	Plasma Cell Myeloma	GDSC	PEDTPVGS	DEG_SCF_FBW7_1	0.1944
p.V50I	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PEDTPVGS	DEG_SCF_FBW7_1	0.5965
p.V50I	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	PEDTPVGS	DEG_SCF_FBW7_1	0.5965
p.T48I	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PEDTPVGS	DEG_SCF_FBW7_1	0.7078
p.T48I	ACH-000983	Leukemia	CCLE	PEDTPVGS	DEG_SCF_FBW7_1	0.7078
p.T48I	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	PEDTPVGS	DEG_SCF_FBW7_1	0.7078
p.N36D	SIDM01018	Hodgkin's Lymphoma	GDSC	PEDTPVGS	DEG_SCF_FBW7_1	0.0833
p.N36D	ACH-000815	Lymphoma	CCLE	PEDTPVGS	DEG_SCF_FBW7_1	0.0833
p.N36D	ACH-001524	Skin Cancer	CCLE	PEDTPVGS	DEG_SCF_FBW7_1	0.0833
p.N36D	ACH-001664	Gastric Cancer	CCLE	PEDTPVGS	DEG_SCF_FBW7_1	0.0833
p.N36D	KM-H2	haematopoietic_and_lymphoid_tissue	COSMIC	PEDTPVGS	DEG_SCF_FBW7_1	0.0833
p.G37R	SIDM01618	B-Lymphoblastic Leukemia	GDSC	PEDTPVGS	DEG_SCF_FBW7_1	0.1111
p.G37R	ACH-000942	Leukemia	CCLE	PEDTPVGS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96JP9	Cadherin-related family member 1	DEG_SCF_FBW7_1	45:52	PEDTPVGS	FBXW7	0.76	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PEDTPVGS

Degron related mutations and impact score

Drug responses associated with CDHR1 mutations

All proteins holding degron of PEDTPVGS