DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LTPTVE
Uniprot ID:
Q96L96
Source protein:
Alpha-protein kinase 3
Source gene:
ALPK3
Class:
DEG_SCF_FBW7_2
Location:
1199:1204
E3 ligase:
FBXW7
DEGRON score:
0.9809
ASA_SCORE:
91.6667
COIL:
0.9175
CONS_SCORE:
0.6037
DSS_SCORE:
0.4604
HELIX:
0.0225
FCONS_SCORE:
1.0407
RIG_SCORE:
0.7975
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G1191E
TCGA-BR-4363
STAD
TCGA
LTPTVE
DEG_SCF_FBW7_2
0.1111
p.G1191E
DO38815
STAD
ICGC
LTPTVE
DEG_SCF_FBW7_2
0.1111
p.R1211W
TCGA-HU-A4H3
STAD
TCGA
LTPTVE
DEG_SCF_FBW7_2
0.1389
p.R1211W
DO47903
STAD
ICGC
LTPTVE
DEG_SCF_FBW7_2
0.1389
p.R1211W
SIDM00999
Bladder Carcinoma
GDSC
LTPTVE
DEG_SCF_FBW7_2
0.1389
p.R1211W
ACH-000973
Bladder Cancer
CCLE
LTPTVE
DEG_SCF_FBW7_2
0.1389
p.R1211W
639-V
urinary_tract
COSMIC
LTPTVE
DEG_SCF_FBW7_2
0.1389
p.R1211Q
SIDM00777
Colorectal Carcinoma
GDSC
LTPTVE
DEG_SCF_FBW7_2
0.1389
p.R1211Q
SIDM00779
Colorectal Carcinoma
GDSC
LTPTVE
DEG_SCF_FBW7_2
0.1389
p.R1211Q
NCI-H508
large_intestine
COSMIC
LTPTVE
DEG_SCF_FBW7_2
0.1389
p.R1211Q
NCI-H716
large_intestine
COSMIC
LTPTVE
DEG_SCF_FBW7_2
0.1389
p.S1196P
ACH-000153
Lung Cancer
CCLE
LTPTVE
DEG_SCF_FBW7_2
0.25
Drug responses associated with ALPK3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LTPTVE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96L96
Alpha-protein kinase 3
DEG_SCF_FBW7_2
1199:1204
LTPTVE
FBXW7
0.9809
More...