DegronMD

Uniprot ID: P51955

Source protein: Serine/threonine-protein kinase Nek2

Source gene: NEK2

Class: DEG_APCC_KENBOX_2

Location: 390:394

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9566

ASA_SCORE: 102.26

COIL: 0.5106

CONS_SCORE: 0.3893

DSS_SCORE: 0.5044

HELIX: 0.4688

FCONS_SCORE: 1.0732

RIG_SCORE: 0.6831

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G388E	TCGA-05-4250	LUAD	TCGA	SKENI	DEG_APCC_KENBOX_2	0.2778
p.G388R	TCGA-06-6389	GBM	TCGA	SKENI	DEG_APCC_KENBOX_2	0.2778
p.S402G	TCGA-A3-A6NN	KIRC	TCGA	SKENI	DEG_APCC_KENBOX_2	0.5556
p.S385P	DO232761	PBCA	ICGC	SKENI	DEG_APCC_KENBOX_2	0.1944
p.Q392K	DO37405	SKCM	ICGC	SKENI	DEG_APCC_KENBOX_2	0.6944
p.R380L	DO47407	SKCM	ICGC	SKENI	DEG_APCC_KENBOX_2	0.0556
p.W381L	DO229208	THCA	ICGC	SKENI	DEG_APCC_KENBOX_2	0.5278
p.N390K	DO43626	UCEC	ICGC	SKENI	DEG_APCC_KENBOX_2	0.6918
p.R380Q	DO41704	UCEC	ICGC	SKENI	DEG_APCC_KENBOX_2	0.0556
p.Q403P	SIDM02021	Esophageal Carcinoma	GDSC	SKENI	DEG_APCC_KENBOX_2	0.0833
p.S387N	SIDM00422	Hodgkin's Lymphoma	GDSC	SKENI	DEG_APCC_KENBOX_2	0.25
p.S387N	ACH-001203	Lymphoma	CCLE	SKENI	DEG_APCC_KENBOX_2	0.25
p.S387N	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	SKENI	DEG_APCC_KENBOX_2	0.25
p.N393K	SIDM01039	Other Solid Cancers	GDSC	SKENI	DEG_APCC_KENBOX_2	0.6918
p.N393K	ACH-001529	Endometrial/Uterine Cancer	CCLE	SKENI	DEG_APCC_KENBOX_2	0.6918
p.N393K	JAR	placenta	COSMIC	SKENI	DEG_APCC_KENBOX_2	0.6918

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13521	Secretogranin-2	DEG_APCC_KENBOX_2	268:272	SKENI	APC,CDC20,FZR1	0.7451	More...
P51955	Serine/threonine-protein kinase Nek2	DEG_APCC_KENBOX_2	390:394	SKENI	APC,CDC20,FZR1	0.9566	More...
Q9NQ76	Matrix extracellular phosphoglycoprotein	DEG_APCC_KENBOX_2	60:64	SKENI	APC,CDC20,FZR1	0.9125	More...
Q9NQX3	Gephyrin [Includes: Molybdopterin adenylyltransferase	DEG_APCC_KENBOX_2	295:299	SKENI	APC,CDC20,FZR1	0.8364	More...
Q9NSY1	BMP-2-inducible protein kinase	DEG_APCC_KENBOX_2	1041:1045	SKENI	APC,CDC20,FZR1	0.9065	More...
Q9NYB5	Solute carrier organic anion transporter family member 1C1	DEG_APCC_KENBOX_2	5:9	SKENI	APC,CDC20,FZR1	0.9756	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons