DegronMD

Uniprot ID: P13521

Source protein: Secretogranin-2

Source gene: SCG2

Class: DEG_APCC_KENBOX_2

Location: 268:272

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7451

ASA_SCORE: 104.12

COIL: 0.3328

CONS_SCORE: 0.7337

DSS_SCORE: 0.6491

HELIX: 0.6642

FCONS_SCORE: 1.1344

RIG_SCORE: 0.6928

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q262K	TCGA-86-8073	LUAD	TCGA	SKENI	DEG_APCC_KENBOX_2	0.1667
p.Q262K	DO23624	LUAD	ICGC	SKENI	DEG_APCC_KENBOX_2	0.1667
p.Q262K	DO230986	LUSC	ICGC	SKENI	DEG_APCC_KENBOX_2	0.1667
p.D280H	TCGA-86-8674	LUAD	TCGA	SKENI	DEG_APCC_KENBOX_2	0.1111
p.D280H	DO25535	LUAD	ICGC	SKENI	DEG_APCC_KENBOX_2	0.1111
p.K274Q	TCGA-AA-3984	COAD	TCGA	SKENI	DEG_APCC_KENBOX_2	0.2778
p.K274Q	DO9002	COAD	ICGC	SKENI	DEG_APCC_KENBOX_2	0.2778
p.E270D	TCGA-AG-A002	READ	TCGA	SKENI	DEG_APCC_KENBOX_2	0.6758
p.E270D	TCGA-B5-A0JY	UCEC	TCGA	SKENI	DEG_APCC_KENBOX_2	0.6758
p.E270D	TCGA-B5-A3FA	UCEC	TCGA	SKENI	DEG_APCC_KENBOX_2	0.6758
p.E270D	DO43041	UCEC	ICGC	SKENI	DEG_APCC_KENBOX_2	0.6758
p.E270D	DO52402	UCEC	ICGC	SKENI	DEG_APCC_KENBOX_2	0.6758
p.Q262H	TCGA-B5-A1MX	UCEC	TCGA	SKENI	DEG_APCC_KENBOX_2	0.1667
p.Q262H	DO41999	UCEC	ICGC	SKENI	DEG_APCC_KENBOX_2	0.1667
p.Q277E	TCGA-CG-5728	STAD	TCGA	SKENI	DEG_APCC_KENBOX_2	0.1944
p.Q277E	DO38619	STAD	ICGC	SKENI	DEG_APCC_KENBOX_2	0.1944
p.E263K	TCGA-EE-A29M	SKCM	TCGA	SKENI	DEG_APCC_KENBOX_2	0.1944
p.E263K	DO37404	SKCM	ICGC	SKENI	DEG_APCC_KENBOX_2	0.1944
p.Q277R	DO228592	LICA	ICGC	SKENI	DEG_APCC_KENBOX_2	0.1944
p.V265A	DO228138	PBCA	ICGC	SKENI	DEG_APCC_KENBOX_2	0.25
p.S268R	DO232224	PBCA	ICGC	SKENI	DEG_APCC_KENBOX_2	0.7427
p.D280N	DO229502	SKCA	ICGC	SKENI	DEG_APCC_KENBOX_2	0.1111
p.I278M	SIDM02014	Esophageal Carcinoma	GDSC	SKENI	DEG_APCC_KENBOX_2	0.1667
p.I272T	SIDM00845	Burkitt's Lymphoma	GDSC	SKENI	DEG_APCC_KENBOX_2	0.5966
p.S259T	SIDM00845	Burkitt's Lymphoma	GDSC	SKENI	DEG_APCC_KENBOX_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13521	Secretogranin-2	DEG_APCC_KENBOX_2	268:272	SKENI	APC,CDC20,FZR1	0.7451	More...
P51955	Serine/threonine-protein kinase Nek2	DEG_APCC_KENBOX_2	390:394	SKENI	APC,CDC20,FZR1	0.9566	More...
Q9NQ76	Matrix extracellular phosphoglycoprotein	DEG_APCC_KENBOX_2	60:64	SKENI	APC,CDC20,FZR1	0.9125	More...
Q9NQX3	Gephyrin [Includes: Molybdopterin adenylyltransferase	DEG_APCC_KENBOX_2	295:299	SKENI	APC,CDC20,FZR1	0.8364	More...
Q9NSY1	BMP-2-inducible protein kinase	DEG_APCC_KENBOX_2	1041:1045	SKENI	APC,CDC20,FZR1	0.9065	More...
Q9NYB5	Solute carrier organic anion transporter family member 1C1	DEG_APCC_KENBOX_2	5:9	SKENI	APC,CDC20,FZR1	0.9756	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons