DegronMD - Q9NSY1(BMP2K)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D960Y	TCGA-20-0991	OV	TCGA	LVPFDE	LIG_APCC_ABBA_1	956:961	Mutation altering degron motif	0.6214
p.D960Y	DO31949	OV	ICGC	LVPFDE	LIG_APCC_ABBA_1	956:961	Mutation altering degron motif	0.6214
p.F863L	TCGA-60-2721	LUSC	TCGA	VETPKQE	DEG_SCF_FBW7_2	848:854	Mutation rewiring degron network	0.0833
p.F863L	DO26447	LUSC	ICGC	VETPKQE	DEG_SCF_FBW7_2	848:854	Mutation rewiring degron network	0.0833
p.T963M	TCGA-AA-A01R	COAD	TCGA	LVPFDE	LIG_APCC_ABBA_1	956:961	Mutation rewiring degron network	0.2778
p.T963M	TCGA-DD-A3A8	LIHC	TCGA	LVPFDE	LIG_APCC_ABBA_1	956:961	Mutation rewiring degron network	0.2778
p.T963M	DO7934	COAD	ICGC	LVPFDE	LIG_APCC_ABBA_1	956:961	Mutation rewiring degron network	0.2778
p.T963M	DO233205	GACA	ICGC	LVPFDE	LIG_APCC_ABBA_1	956:961	Mutation rewiring degron network	0.2778
p.T963M	DO44883	LIHC	ICGC	LVPFDE	LIG_APCC_ABBA_1	956:961	Mutation rewiring degron network	0.2778
p.R1055K	TCGA-AD-A5EJ	COAD	TCGA	SKENI	DEG_APCC_KENBOX_2	1041:1045	Mutation rewiring degron network	0.0556
p.R1055K	TCGA-D3-A5GR	SKCM	TCGA	SKENI	DEG_APCC_KENBOX_2	1041:1045	Mutation rewiring degron network	0.0556
p.R1055K	DO50090	COAD	ICGC	SKENI	DEG_APCC_KENBOX_2	1041:1045	Mutation rewiring degron network	0.0556
p.R1055K	DO47436	SKCM	ICGC	SKENI	DEG_APCC_KENBOX_2	1041:1045	Mutation rewiring degron network	0.0556
p.E951D	TCGA-AX-A2HC	UCEC	TCGA	LVPFDE	LIG_APCC_ABBA_1	956:961	Mutation rewiring degron network	0.1944
p.E951D	TCGA-H4-A2HO	BLCA	TCGA	LVPFDE	LIG_APCC_ABBA_1	956:961	Mutation rewiring degron network	0.1944
p.E951D	DO494	BLCA	ICGC	LVPFDE	LIG_APCC_ABBA_1	956:961	Mutation rewiring degron network	0.1944
p.E951D	DO41572	UCEC	ICGC	LVPFDE	LIG_APCC_ABBA_1	956:961	Mutation rewiring degron network	0.1944
p.K969R	TCGA-DI-A1BU	UCEC	TCGA	LVPFDE	LIG_APCC_ABBA_1	956:961	Mutation substituting flanking lysine	0.2222
p.K969R	DO42023	UCEC	ICGC	LVPFDE	LIG_APCC_ABBA_1	956:961	Mutation substituting flanking lysine	0.2222
p.V848M	TCGA-EO-A3AZ	UCEC	TCGA	VETPKQE	DEG_SCF_FBW7_2	848:854	Mutation altering degron motif	0.6097
p.V848M	DO50078	UCEC	ICGC	VETPKQE	DEG_SCF_FBW7_2	848:854	Mutation altering degron motif	0.6097
p.D1051Y	TCGA-LT-A5Z6	BLCA	TCGA	SKENI	DEG_APCC_KENBOX_2	1041:1045	Mutation rewiring degron network	0.1667
p.D1051Y	DO44029	BLCA	ICGC	SKENI	DEG_APCC_KENBOX_2	1041:1045	Mutation rewiring degron network	0.1667
p.S965T	TCGA-ZF-A9R9	BLCA	TCGA	LVPFDE	LIG_APCC_ABBA_1	956:961	Mutation rewiring degron network	0.2222
p.S965T	DO219066	BLCA	ICGC	LVPFDE	LIG_APCC_ABBA_1	956:961	Mutation rewiring degron network	0.2222
p.K971Q	DO225390	BRCA	ICGC	LVPFDE	LIG_APCC_ABBA_1	956:961	Mutation substituting flanking lysine	0.1667
p.V970L	DO225390	BRCA	ICGC	LVPFDE	LIG_APCC_ABBA_1	956:961	Mutation rewiring degron network	0.0833
p.Q966H	DO228974	LICA	ICGC	LVPFDE	LIG_APCC_ABBA_1	956:961	Mutation rewiring degron network	0.1944
p.Q966H	DO229006	LICA	ICGC	LVPFDE	LIG_APCC_ABBA_1	956:961	Mutation rewiring degron network	0.1944
p.Q967H	DO229029	LICA	ICGC	LVPFDE	LIG_APCC_ABBA_1	956:961	Mutation rewiring degron network	0.1667
p.S965I	DO27895	ORCA	ICGC	LVPFDE	LIG_APCC_ABBA_1	956:961	Mutation rewiring degron network	0.2222
p.F855C	DO52129	PAEN	ICGC	VETPKQE	DEG_SCF_FBW7_2	848:854	Mutation rewiring degron network	0.3056
p.S844C	SIDM00860	Head and Neck Carcinoma	GDSC	VETPKQE	DEG_SCF_FBW7_2	848:854	Mutation rewiring degron network	0.2222
p.S844C	FADU	upper aerodigestive tract	COSMIC	VETPKQE	DEG_SCF_FBW7_2	848:854	Mutation rewiring degron network	0.2222
p.D1040H	SIDM00660	Colorectal Carcinoma	GDSC	SKENI	DEG_APCC_KENBOX_2	1041:1045	Mutation rewiring degron network	0.3056
p.D1040H	ACH-000985	Colon/Colorectal Cancer	CCLE	SKENI	DEG_APCC_KENBOX_2	1041:1045	Mutation rewiring degron network	0.3056
p.D1040H	LS-411N	large intestine	COSMIC	SKENI	DEG_APCC_KENBOX_2	1041:1045	Mutation rewiring degron network	0.3056
p.E849G	SIDM01659	Kidney Carcinoma	GDSC	VETPKQE	DEG_SCF_FBW7_2	848:854	Mutation altering degron motif	0.6087
p.E849G	ACH-000313	Kidney Cancer	CCLE	VETPKQE	DEG_SCF_FBW7_2	848:854	Mutation altering degron motif	0.6087

Kaplan plot for BMP2K in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BMP2K

UniProt ID: Q9NSY1

Entrez ID: 55589

Protein name: BMP-2-inducible protein kinase (BIKe) (EC 2.7.11.1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BMP2K in