DegronMD

Uniprot ID: Q9NSY1

Source protein: BMP-2-inducible protein kinase

Source gene: BMP2K

Class: LIG_APCC_ABBA_1

Location: 956:961

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9239

ASA_SCORE: 67.4833

COIL: 0.6133

CONS_SCORE: 0.3146

DSS_SCORE: 0.4521

HELIX: 0.3328

FCONS_SCORE: 1.1761

RIG_SCORE: 0.8018

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D960Y	TCGA-20-0991	OV	TCGA	LVPFDE	LIG_APCC_ABBA_1	0.6214
p.D960Y	DO31949	OV	ICGC	LVPFDE	LIG_APCC_ABBA_1	0.6214
p.T963M	TCGA-AA-A01R	COAD	TCGA	LVPFDE	LIG_APCC_ABBA_1	0.2778
p.T963M	TCGA-DD-A3A8	LIHC	TCGA	LVPFDE	LIG_APCC_ABBA_1	0.2778
p.T963M	DO7934	COAD	ICGC	LVPFDE	LIG_APCC_ABBA_1	0.2778
p.T963M	DO233205	GACA	ICGC	LVPFDE	LIG_APCC_ABBA_1	0.2778
p.T963M	DO44883	LIHC	ICGC	LVPFDE	LIG_APCC_ABBA_1	0.2778
p.E951D	TCGA-AX-A2HC	UCEC	TCGA	LVPFDE	LIG_APCC_ABBA_1	0.1944
p.E951D	TCGA-H4-A2HO	BLCA	TCGA	LVPFDE	LIG_APCC_ABBA_1	0.1944
p.E951D	DO494	BLCA	ICGC	LVPFDE	LIG_APCC_ABBA_1	0.1944
p.E951D	DO41572	UCEC	ICGC	LVPFDE	LIG_APCC_ABBA_1	0.1944
p.K969R	TCGA-DI-A1BU	UCEC	TCGA	LVPFDE	LIG_APCC_ABBA_1	0.2222
p.K969R	DO42023	UCEC	ICGC	LVPFDE	LIG_APCC_ABBA_1	0.2222
p.S965T	TCGA-ZF-A9R9	BLCA	TCGA	LVPFDE	LIG_APCC_ABBA_1	0.2222
p.S965T	DO219066	BLCA	ICGC	LVPFDE	LIG_APCC_ABBA_1	0.2222
p.K971Q	DO225390	BRCA	ICGC	LVPFDE	LIG_APCC_ABBA_1	0.1667
p.V970L	DO225390	BRCA	ICGC	LVPFDE	LIG_APCC_ABBA_1	0.0833
p.Q966H	DO228974	LICA	ICGC	LVPFDE	LIG_APCC_ABBA_1	0.1944
p.Q966H	DO229006	LICA	ICGC	LVPFDE	LIG_APCC_ABBA_1	0.1944
p.Q967H	DO229029	LICA	ICGC	LVPFDE	LIG_APCC_ABBA_1	0.1667
p.S965I	DO27895	ORCA	ICGC	LVPFDE	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NSY1	BMP-2-inducible protein kinase	LIG_APCC_ABBA_1	956:961	LVPFDE	APC,CDC20,FZR1	0.9239	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons