DegronMD

Uniprot ID: Q9NSY1

Source protein: BMP-2-inducible protein kinase

Source gene: BMP2K

Class: DEG_SCF_FBW7_2

Location: 848:854

E3 ligase: FBXW7

DEGRON score: 0.5635

ASA_SCORE: 92.1

COIL: 0.7474

CONS_SCORE: 0.2271

DSS_SCORE: 0.3055

HELIX: 0.1447

FCONS_SCORE: 0.8801

RIG_SCORE: 0.7714

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F863L	TCGA-60-2721	LUSC	TCGA	VETPKQE	DEG_SCF_FBW7_2	0.0833
p.F863L	DO26447	LUSC	ICGC	VETPKQE	DEG_SCF_FBW7_2	0.0833
p.V848M	TCGA-EO-A3AZ	UCEC	TCGA	VETPKQE	DEG_SCF_FBW7_2	0.6097
p.V848M	DO50078	UCEC	ICGC	VETPKQE	DEG_SCF_FBW7_2	0.6097
p.F855C	DO52129	PAEN	ICGC	VETPKQE	DEG_SCF_FBW7_2	0.3056
p.S844C	SIDM00860	Head and Neck Carcinoma	GDSC	VETPKQE	DEG_SCF_FBW7_2	0.2222
p.S844C	FADU	upper_aerodigestive_tract	COSMIC	VETPKQE	DEG_SCF_FBW7_2	0.2222
p.E849G	SIDM01659	Kidney Carcinoma	GDSC	VETPKQE	DEG_SCF_FBW7_2	0.6087
p.E849G	ACH-000313	Kidney Cancer	CCLE	VETPKQE	DEG_SCF_FBW7_2	0.6087

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NSY1	BMP-2-inducible protein kinase	DEG_SCF_FBW7_2	848:854	VETPKQE	FBXW7	0.5635	More...
Q5H9B9	Putative BMP-2-inducible kinase-like protein	DEG_SCF_FBW7_2	103:109	VETPKQE	FBXW7	0.518	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons