DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VETPKQE
Uniprot ID:
Q5H9B9
Source protein:
Putative BMP-2-inducible kinase-like protein
Source gene:
BMP2KL
Class:
DEG_SCF_FBW7_2
Location:
103:109
E3 ligase:
FBXW7
DEGRON score:
0.518
ASA_SCORE:
89.5571
COIL:
0.7254
CONS_SCORE:
0
DSS_SCORE:
0.3271
HELIX:
0.1581
FCONS_SCORE:
0
RIG_SCORE:
0.7682
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with BMP2KL mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VETPKQE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9NSY1
BMP-2-inducible protein kinase
DEG_SCF_FBW7_2
848:854
VETPKQE
FBXW7
0.5635
More...
Q5H9B9
Putative BMP-2-inducible kinase-like protein
DEG_SCF_FBW7_2
103:109
VETPKQE
FBXW7
0.518
More...