DegronMD - Q9NQX3(GPHN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G264C	TCGA-09-2044	OV	TCGA	LSTTPSES	DEG_SCF_FBW7_1	263:270	Mutation altering degron motif	0.76
p.G264C	DO28923	OV	ICGC	LSTTPSES	DEG_SCF_FBW7_1	263:270	Mutation altering degron motif	0.76
p.S297T	TCGA-23-1032	OV	TCGA	SKENI	DEG_APCC_KENBOX_2	295:299	Mutation altering degron motif	0.7116
p.S297T	DO32267	OV	ICGC	SKENI	DEG_APCC_KENBOX_2	295:299	Mutation altering degron motif	0.7116
p.P197L	TCGA-56-8504	LUSC	TCGA	PPTTS	DEG_SPOP_SBC_1	196:200	Mutation altering degron motif	0.6471
p.P304S	TCGA-A5-A1OF	UCEC	TCGA	SKENI	DEG_APCC_KENBOX_2	295:299	Mutation rewiring degron network	0.1944
p.T273A	TCGA-AA-A01I	COAD	TCGA	LSTTPSES	DEG_SCF_FBW7_1	263:270	Mutation rewiring degron network	0.25
p.T273A	DO10510	COAD	ICGC	LSTTPSES	DEG_SCF_FBW7_1	263:270	Mutation rewiring degron network	0.25
p.R276W	TCGA-AP-A0LM	UCEC	TCGA	LSTTPSES	DEG_SCF_FBW7_1	263:270	Mutation blocking phosphorylation signal	0.6111
p.R276W	DO228532	MALY	ICGC	LSTTPSES	DEG_SCF_FBW7_1	263:270	Mutation blocking phosphorylation signal	0.6111
p.R276W	DO43306	UCEC	ICGC	LSTTPSES	DEG_SCF_FBW7_1	263:270	Mutation blocking phosphorylation signal	0.6111
p.E213G	TCGA-BP-4167	KIRC	TCGA	DSGVAST	DEG_SCF_TRCP1_1	221:227	Mutation rewiring degron network	0.1111
p.S303L	TCGA-BR-4201	STAD	TCGA	SKENI	DEG_APCC_KENBOX_2	295:299	Mutation blocking phosphorylation signal	0.6667
p.S303L	DO38707	STAD	ICGC	SKENI	DEG_APCC_KENBOX_2	295:299	Mutation blocking phosphorylation signal	0.6667
p.D292H	TCGA-BR-7716	STAD	TCGA	SKENI	DEG_APCC_KENBOX_2	295:299	Mutation rewiring degron network	0.25
p.D292H	DO38675	STAD	ICGC	SKENI	DEG_APCC_KENBOX_2	295:299	Mutation rewiring degron network	0.25
p.D221H	TCGA-CR-7398	HNSC	TCGA	DSGVAST	DEG_SCF_TRCP1_1	221:227	Mutation altering degron motif	0.7688
p.E259K	TCGA-CV-7235	HNSC	TCGA	LSTTPSES	DEG_SCF_FBW7_1	263:270	Mutation rewiring degron network	0.2222
p.E259K	DO15102	HNSC	ICGC	LSTTPSES	DEG_SCF_FBW7_1	263:270	Mutation rewiring degron network	0.2222
p.L193V	TCGA-E5-A4TZ	BLCA	TCGA	PPTTS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.25
p.L193V	DO44055	BLCA	ICGC	PPTTS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.25
p.P278S	TCGA-EB-A5SG	SKCM	TCGA	LSTTPSES	DEG_SCF_FBW7_1	263:270	Mutation rewiring degron network	0.1111
p.P278S	SIDM01768	Melanoma	GDSC	LSTTPSES	DEG_SCF_FBW7_1	263:270	Mutation rewiring degron network	0.1111
p.P278S	ACH-000899	Skin Cancer	CCLE	LSTTPSES	DEG_SCF_FBW7_1	263:270	Mutation rewiring degron network	0.1111
p.E206K	TCGA-EO-A22U	UCEC	TCGA	PPTTS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.1667
p.P300L	TCGA-FI-A2D0	UCEC	TCGA	SKENI	DEG_APCC_KENBOX_2	295:299	Mutation rewiring degron network	0.3056
p.P300L	SIDM00545	Melanoma	GDSC	SKENI	DEG_APCC_KENBOX_2	295:299	Mutation rewiring degron network	0.3056
p.P300L	ACH-000987	Skin Cancer	CCLE	SKENI	DEG_APCC_KENBOX_2	295:299	Mutation rewiring degron network	0.3056
p.P300L	Mewo	skin	COSMIC	SKENI	DEG_APCC_KENBOX_2	295:299	Mutation rewiring degron network	0.3056
p.R291Q	TCGA-GN-A263	SKCM	TCGA	SKENI	DEG_APCC_KENBOX_2	295:299	Mutation blocking phosphorylation signal	0.6667
p.R291Q	DO37766	SKCM	ICGC	SKENI	DEG_APCC_KENBOX_2	295:299	Mutation blocking phosphorylation signal	0.6667
p.E218D	TCGA-L9-A8F4	LUAD	TCGA	DSGVAST	DEG_SCF_TRCP1_1	221:227	Mutation rewiring degron network	0.25
p.R276Q	TCGA-VQ-A8P2	STAD	TCGA	LSTTPSES	DEG_SCF_FBW7_1	263:270	Mutation blocking phosphorylation signal	0.6111
p.R276Q	DO222501	COCA	ICGC	LSTTPSES	DEG_SCF_FBW7_1	263:270	Mutation blocking phosphorylation signal	0.6111
p.R276Q	DO51761	STAD	ICGC	LSTTPSES	DEG_SCF_FBW7_1	263:270	Mutation blocking phosphorylation signal	0.6111
p.S297C	TCGA-WE-A8ZR	SKCM	TCGA	SKENI	DEG_APCC_KENBOX_2	295:299	Mutation altering degron motif	0.7541
p.M305I	DO51927	BLCA	ICGC	SKENI	DEG_APCC_KENBOX_2	295:299	Mutation blocking phosphorylation signal	0.6111
p.G192A	DO10324	COAD	ICGC	PPTTS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.2222
p.R220H	DO233254	GACA	ICGC	DSGVAST	DEG_SCF_TRCP1_1	221:227	Mutation rewiring degron network	0.3056
p.D190H	DO14782	HNSC	ICGC	PPTTS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.1667
p.S233I	DO229034	LICA	ICGC	DSGVAST	DEG_SCF_TRCP1_1	221:227	Mutation rewiring degron network	0.1667
p.A210S	DO50922	LICA	ICGC	PPTTS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.0556
p.C212Y	DO45189	LIRI	ICGC	DSGVAST	DEG_SCF_TRCP1_1	221:227	Mutation rewiring degron network	0.0833
p.E187D	DO49876	LUAD	ICGC	PPTTS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.0833
p.T306S	DO228353	MALY	ICGC	SKENI	DEG_APCC_KENBOX_2	295:299	Mutation rewiring degron network	0.1389
p.R291L	DO46420	OV	ICGC	SKENI	DEG_APCC_KENBOX_2	295:299	Mutation blocking phosphorylation signal	0.6667
p.P261A	DO35128	PACA	ICGC	LSTTPSES	DEG_SCF_FBW7_1	263:270	Mutation rewiring degron network	0.2778
p.P291S	DO229446	SKCA	ICGC	SKENI	DEG_APCC_KENBOX_2	295:299	Mutation blocking phosphorylation signal	0.6667
p.P300S	DO218849	SKCA	ICGC	SKENI	DEG_APCC_KENBOX_2	295:299	Mutation rewiring degron network	0.3056
p.P263S	DO229502	SKCA	ICGC	LSTTPSES	DEG_SCF_FBW7_1	263:270	Mutation altering degron motif	0.6752
p.P214S	DO48726	SKCM	ICGC	DSGVAST	DEG_SCF_TRCP1_1	221:227	Mutation rewiring degron network	0.1389
p.N267S	DO47619	SKCM	ICGC	LSTTPSES	DEG_SCF_FBW7_1	263:270	Mutation altering degron motif	0.7069
p.S233C	DO51289	SKCM	ICGC	DSGVAST	DEG_SCF_TRCP1_1	221:227	Mutation rewiring degron network	0.1667
p.K265N	DO47869	STAD	ICGC	LSTTPSES	DEG_SCF_FBW7_1	263:270	Mutation altering degron motif	0.6918
p.L232I	DO229248	THCA	ICGC	DSGVAST	DEG_SCF_TRCP1_1	221:227	Mutation rewiring degron network	0.1944
p.L269F	DO42033	UCEC	ICGC	LSTTPSES	DEG_SCF_FBW7_1	263:270	Mutation altering degron motif	0.6981
p.S219F	DO43041	UCEC	ICGC	DSGVAST	DEG_SCF_TRCP1_1	221:227	Mutation rewiring degron network	0.2778
p.P307L	DO52402	UCEC	ICGC	SKENI	DEG_APCC_KENBOX_2	295:299	Mutation rewiring degron network	0.1111
p.P236L	DO43891	UCEC	ICGC	DSGVAST	DEG_SCF_TRCP1_1	221:227	Mutation rewiring degron network	0.0833
p.S288Y	DO43971	UCEC	ICGC	SKENI	DEG_APCC_KENBOX_2	295:299	Mutation substituting flanking lysine	0.25
p.A294V	SIDM02021	Esophageal Carcinoma	GDSC	SKENI	DEG_APCC_KENBOX_2	295:299	Mutation blocking phosphorylation signal	0.75
p.S230G	SIDM00537	Colorectal Carcinoma	GDSC	DSGVAST	DEG_SCF_TRCP1_1	221:227	Mutation blocking phosphorylation signal	0.6944
p.S230G	GP5d	large intestine	COSMIC	DSGVAST	DEG_SCF_TRCP1_1	221:227	Mutation blocking phosphorylation signal	0.6944
p.H271N	SIDM00949	T-Cell Non-Hodgkin's Lymphoma	GDSC	LSTTPSES	DEG_SCF_FBW7_1	263:270	Mutation rewiring degron network	0.3056
p.H271N	ACH-000233	Lymphoma	CCLE	LSTTPSES	DEG_SCF_FBW7_1	263:270	Mutation rewiring degron network	0.3056
p.H271N	DEL	haematopoietic and lymphoid tissue	COSMIC	LSTTPSES	DEG_SCF_FBW7_1	263:270	Mutation rewiring degron network	0.3056
p.Q307H	SIDM00721	Small Cell Lung Carcinoma	GDSC	SKENI	DEG_APCC_KENBOX_2	295:299	Mutation rewiring degron network	0.1111
p.Q307H	ACH-002171	Lung Cancer	CCLE	SKENI	DEG_APCC_KENBOX_2	295:299	Mutation rewiring degron network	0.1111
p.Q307H	NCI-H250	lung	COSMIC	SKENI	DEG_APCC_KENBOX_2	295:299	Mutation rewiring degron network	0.1111
p.T198A	ACH-001214	Brain Cancer	CCLE	PPTTS	DEG_SPOP_SBC_1	196:200	Mutation altering degron motif	0.825
p.K208T	ACH-001664	Gastric Cancer	CCLE	PPTTS	DEG_SPOP_SBC_1	196:200	Mutation substituting flanking lysine	0.2222
p.A294T	ACH-001735	Leukemia	CCLE	SKENI	DEG_APCC_KENBOX_2	295:299	Mutation blocking phosphorylation signal	0.75
p.P233S	DBTRG-05MG	central nervous system	COSMIC	DSGVAST	DEG_SCF_TRCP1_1	221:227	Mutation rewiring degron network	0.1667
p.Q289H	NCI-H250	lung	COSMIC	SKENI	DEG_APCC_KENBOX_2	295:299	Mutation rewiring degron network	0.1667
p.Q274H	NCI-H250	lung	COSMIC	LSTTPSES	DEG_SCF_FBW7_1	263:270	Mutation rewiring degron network	0.2222
p.P267L	Mewo	skin	COSMIC	LSTTPSES	DEG_SCF_FBW7_1	263:270	Mutation altering degron motif	0.7582
p.H253N	DEL	haematopoietic and lymphoid tissue	COSMIC	LSTTPSES	DEG_SCF_FBW7_1	263:270	Mutation rewiring degron network	0.0556
p.S212G	GP5d	large intestine	COSMIC	DSGVAST	DEG_SCF_TRCP1_1	221:227	Mutation rewiring degron network	0.0833
p.Q287H	NCI-H250	lung	COSMIC	SKENI	DEG_APCC_KENBOX_2	295:299	Mutation rewiring degron network	0.1111
p.I309V	CW-2	large intestine	COSMIC	SKENI	DEG_APCC_KENBOX_2	295:299	Mutation rewiring degron network	0.0556
p.P280L	Mewo	skin	COSMIC	LSTTPSES	DEG_SCF_FBW7_1	263:270	Mutation blocking phosphorylation signal	0.5
p.S232G	EN	endometrium	COSMIC	DSGVAST	DEG_SCF_TRCP1_1	221:227	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GPHN

UniProt ID: Q9NQX3

Entrez ID: 10243

Protein name: Gephyrin [Includes: Molybdopterin adenylyltransferase (MPT adenylyltransferase) (EC 2.7.7.75) (Domain G); Molybdopterin molybdenumtransferase (MPT Mo-transferase) (EC 2.10.1.1) (Domain E)]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GPHN in