DegronMD

Uniprot ID: Q9NQX3

Source protein: Gephyrin [Includes: Molybdopterin adenylyltransferase

Source gene: GPHN

Class: DEG_SCF_TRCP1_1

Location: 221:227

E3 ligase: BTRC

DEGRON score: 0.9985

ASA_SCORE: 70.3857

COIL: 0.851

CONS_SCORE: 0.2024

DSS_SCORE: 0.7177

HELIX: 0.1023

FCONS_SCORE: 1.0902

RIG_SCORE: 0.6232

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E213G	TCGA-BP-4167	KIRC	TCGA	DSGVAST	DEG_SCF_TRCP1_1	0.1111
p.D221H	TCGA-CR-7398	HNSC	TCGA	DSGVAST	DEG_SCF_TRCP1_1	0.7688
p.E218D	TCGA-L9-A8F4	LUAD	TCGA	DSGVAST	DEG_SCF_TRCP1_1	0.25
p.R220H	DO233254	GACA	ICGC	DSGVAST	DEG_SCF_TRCP1_1	0.3056
p.S233I	DO229034	LICA	ICGC	DSGVAST	DEG_SCF_TRCP1_1	0.1667
p.C212Y	DO45189	LIRI	ICGC	DSGVAST	DEG_SCF_TRCP1_1	0.0833
p.P214S	DO48726	SKCM	ICGC	DSGVAST	DEG_SCF_TRCP1_1	0.1389
p.S233C	DO51289	SKCM	ICGC	DSGVAST	DEG_SCF_TRCP1_1	0.1667
p.L232I	DO229248	THCA	ICGC	DSGVAST	DEG_SCF_TRCP1_1	0.1944
p.S219F	DO43041	UCEC	ICGC	DSGVAST	DEG_SCF_TRCP1_1	0.2778
p.P236L	DO43891	UCEC	ICGC	DSGVAST	DEG_SCF_TRCP1_1	0.0833
p.S230G	SIDM00537	Colorectal Carcinoma	GDSC	DSGVAST	DEG_SCF_TRCP1_1	0.6944
p.S230G	GP5d	large_intestine	COSMIC	DSGVAST	DEG_SCF_TRCP1_1	0.6944
p.P233S	DBTRG-05MG	central_nervous_system	COSMIC	DSGVAST	DEG_SCF_TRCP1_1	0.1667
p.S212G	GP5d	large_intestine	COSMIC	DSGVAST	DEG_SCF_TRCP1_1	0.0833
p.S232G	EN	endometrium	COSMIC	DSGVAST	DEG_SCF_TRCP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQX3	Gephyrin [Includes: Molybdopterin adenylyltransferase	DEG_SCF_TRCP1_1	221:227	DSGVAST	BTRC	0.9985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons