DegronMD

Uniprot ID: Q9NQX3

Source protein: Gephyrin [Includes: Molybdopterin adenylyltransferase

Source gene: GPHN

Class: DEG_SCF_FBW7_1

Location: 263:270

E3 ligase: FBXW7

DEGRON score: 0.9964

ASA_SCORE: 72.25

COIL: 0.7365

CONS_SCORE: 0.1503

DSS_SCORE: 0.641

HELIX: 0.0284

FCONS_SCORE: 1.009

RIG_SCORE: 0.6217

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G264C	TCGA-09-2044	OV	TCGA	LSTTPSES	DEG_SCF_FBW7_1	0.76
p.G264C	DO28923	OV	ICGC	LSTTPSES	DEG_SCF_FBW7_1	0.76
p.T273A	TCGA-AA-A01I	COAD	TCGA	LSTTPSES	DEG_SCF_FBW7_1	0.25
p.T273A	DO10510	COAD	ICGC	LSTTPSES	DEG_SCF_FBW7_1	0.25
p.R276W	TCGA-AP-A0LM	UCEC	TCGA	LSTTPSES	DEG_SCF_FBW7_1	0.6111
p.R276W	DO228532	MALY	ICGC	LSTTPSES	DEG_SCF_FBW7_1	0.6111
p.R276W	DO43306	UCEC	ICGC	LSTTPSES	DEG_SCF_FBW7_1	0.6111
p.E259K	TCGA-CV-7235	HNSC	TCGA	LSTTPSES	DEG_SCF_FBW7_1	0.2222
p.E259K	DO15102	HNSC	ICGC	LSTTPSES	DEG_SCF_FBW7_1	0.2222
p.P278S	TCGA-EB-A5SG	SKCM	TCGA	LSTTPSES	DEG_SCF_FBW7_1	0.1111
p.P278S	SIDM01768	Melanoma	GDSC	LSTTPSES	DEG_SCF_FBW7_1	0.1111
p.P278S	ACH-000899	Skin Cancer	CCLE	LSTTPSES	DEG_SCF_FBW7_1	0.1111
p.R276Q	TCGA-VQ-A8P2	STAD	TCGA	LSTTPSES	DEG_SCF_FBW7_1	0.6111
p.R276Q	DO222501	COCA	ICGC	LSTTPSES	DEG_SCF_FBW7_1	0.6111
p.R276Q	DO51761	STAD	ICGC	LSTTPSES	DEG_SCF_FBW7_1	0.6111
p.P261A	DO35128	PACA	ICGC	LSTTPSES	DEG_SCF_FBW7_1	0.2778
p.P263S	DO229502	SKCA	ICGC	LSTTPSES	DEG_SCF_FBW7_1	0.6752
p.N267S	DO47619	SKCM	ICGC	LSTTPSES	DEG_SCF_FBW7_1	0.7069
p.K265N	DO47869	STAD	ICGC	LSTTPSES	DEG_SCF_FBW7_1	0.6918
p.L269F	DO42033	UCEC	ICGC	LSTTPSES	DEG_SCF_FBW7_1	0.6981
p.H271N	SIDM00949	T-Cell Non-Hodgkin's Lymphoma	GDSC	LSTTPSES	DEG_SCF_FBW7_1	0.3056
p.H271N	ACH-000233	Lymphoma	CCLE	LSTTPSES	DEG_SCF_FBW7_1	0.3056
p.H271N	DEL	haematopoietic_and_lymphoid_tissue	COSMIC	LSTTPSES	DEG_SCF_FBW7_1	0.3056
p.Q274H	NCI-H250	lung	COSMIC	LSTTPSES	DEG_SCF_FBW7_1	0.2222
p.P267L	Mewo	skin	COSMIC	LSTTPSES	DEG_SCF_FBW7_1	0.7582
p.H253N	DEL	haematopoietic_and_lymphoid_tissue	COSMIC	LSTTPSES	DEG_SCF_FBW7_1	0.0556
p.P280L	Mewo	skin	COSMIC	LSTTPSES	DEG_SCF_FBW7_1	0.5

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQX3	Gephyrin [Includes: Molybdopterin adenylyltransferase	DEG_SCF_FBW7_1	263:270	LSTTPSES	FBXW7	0.9964	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LSTTPSES

Degron related mutations and impact score

Drug responses associated with GPHN mutations

All proteins holding degron of LSTTPSES