DegronMD - P13521(SCG2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y81C	TCGA-28-1747	GBM	TCGA	QKENG	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.0833
p.Y81C	DO13096	GBM	ICGC	QKENG	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.0833
p.Q262K	TCGA-86-8073	LUAD	TCGA	SKENI	DEG_APCC_KENBOX_2	268:272	Mutation rewiring degron network	0.1667
p.Q262K	DO23624	LUAD	ICGC	SKENI	DEG_APCC_KENBOX_2	268:272	Mutation rewiring degron network	0.1667
p.Q262K	DO230986	LUSC	ICGC	SKENI	DEG_APCC_KENBOX_2	268:272	Mutation rewiring degron network	0.1667
p.D280H	TCGA-86-8674	LUAD	TCGA	SKENI	DEG_APCC_KENBOX_2	268:272	Mutation rewiring degron network	0.1111
p.D280H	DO25535	LUAD	ICGC	SKENI	DEG_APCC_KENBOX_2	268:272	Mutation rewiring degron network	0.1111
p.Q82E	TCGA-95-7043	LUAD	TCGA	QKENG	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.1111
p.Q82E	TCGA-IR-A3LL	CESC	TCGA	QKENG	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.1111
p.Q82E	DO44362	CESC	ICGC	QKENG	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.1111
p.Q82E	DO24739	LUAD	ICGC	QKENG	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.1111
p.R159I	TCGA-A5-A0G2	UCEC	TCGA	PPMY	ITCH	167:170	Mutation rewiring degron network	0.1111
p.R159I	DO41235	UCEC	ICGC	PPMY	ITCH	167:170	Mutation rewiring degron network	0.1111
p.E172D	TCGA-A5-A2K5	UCEC	TCGA	PPMY	ITCH	167:170	Mutation rewiring degron network	0.2778
p.E172D	TCGA-EO-A3AY	UCEC	TCGA	PPMY	ITCH	167:170	Mutation rewiring degron network	0.2778
p.E172D	DO43202	UCEC	ICGC	PPMY	ITCH	167:170	Mutation rewiring degron network	0.2778
p.E172D	DO41379	UCEC	ICGC	PPMY	ITCH	167:170	Mutation rewiring degron network	0.2778
p.E172D	SIDM01588	Endometrial Carcinoma	GDSC	PPMY	ITCH	167:170	Mutation rewiring degron network	0.2778
p.E172D	ACH-000993	Endometrial/Uterine Cancer	CCLE	PPMY	ITCH	167:170	Mutation rewiring degron network	0.2778
p.K274Q	TCGA-AA-3984	COAD	TCGA	SKENI	DEG_APCC_KENBOX_2	268:272	Mutation rewiring degron network	0.2778
p.K274Q	DO9002	COAD	ICGC	SKENI	DEG_APCC_KENBOX_2	268:272	Mutation rewiring degron network	0.2778
p.D95N	TCGA-AG-3892	READ	TCGA	QKENG	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.3056
p.D95N	TCGA-CD-8528	STAD	TCGA	QKENG	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.3056
p.D95N	DO222765	COCA	ICGC	QKENG	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.3056
p.D95N	DO28763	OV	ICGC	QKENG	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.3056
p.D95N	DO36394	READ	ICGC	QKENG	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.3056
p.D95N	DO47729	STAD	ICGC	QKENG	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.3056
p.E270D	TCGA-AG-A002	READ	TCGA	SKENI	DEG_APCC_KENBOX_2	268:272	Mutation altering degron motif	0.6758
p.E270D	TCGA-B5-A0JY	UCEC	TCGA	SKENI	DEG_APCC_KENBOX_2	268:272	Mutation altering degron motif	0.6758
p.E270D	TCGA-B5-A3FA	UCEC	TCGA	SKENI	DEG_APCC_KENBOX_2	268:272	Mutation altering degron motif	0.6758
p.E270D	DO43041	UCEC	ICGC	SKENI	DEG_APCC_KENBOX_2	268:272	Mutation altering degron motif	0.6758
p.E270D	DO52402	UCEC	ICGC	SKENI	DEG_APCC_KENBOX_2	268:272	Mutation altering degron motif	0.6758
p.P168S	TCGA-AG-A002	READ	TCGA	PPMY	ITCH	167:170	Mutation altering degron motif	0.6752
p.P168S	TCGA-FJ-A3Z7	BLCA	TCGA	PPMY	ITCH	167:170	Mutation altering degron motif	0.6752
p.P168S	DO463	BLCA	ICGC	PPMY	ITCH	167:170	Mutation altering degron motif	0.6752
p.K141N	TCGA-AJ-A3EL	UCEC	TCGA	PKENK	DEG_APCC_KENBOX_2	129:133	Mutation substituting flanking lysine	0.2222
p.K141N	TCGA-EO-A22X	UCEC	TCGA	PKENK	DEG_APCC_KENBOX_2	129:133	Mutation substituting flanking lysine	0.2222
p.K141N	DO41542	UCEC	ICGC	PKENK	DEG_APCC_KENBOX_2	129:133	Mutation substituting flanking lysine	0.2222
p.K141N	DO43907	UCEC	ICGC	PKENK	DEG_APCC_KENBOX_2	129:133	Mutation substituting flanking lysine	0.2222
p.N177T	TCGA-AP-A1DK	UCEC	TCGA	PPMY	ITCH	167:170	Mutation rewiring degron network	0.1389
p.N177T	DO42033	UCEC	ICGC	PPMY	ITCH	167:170	Mutation rewiring degron network	0.1389
p.Q262H	TCGA-B5-A1MX	UCEC	TCGA	SKENI	DEG_APCC_KENBOX_2	268:272	Mutation rewiring degron network	0.1667
p.Q262H	DO41999	UCEC	ICGC	SKENI	DEG_APCC_KENBOX_2	268:272	Mutation rewiring degron network	0.1667
p.P129L	TCGA-BP-5178	KIRC	TCGA	PKENK	DEG_APCC_KENBOX_2	129:133	Mutation altering degron motif	0.6471
p.P129L	DO18582	KIRC	ICGC	PKENK	DEG_APCC_KENBOX_2	129:133	Mutation altering degron motif	0.6471
p.Q277E	TCGA-CG-5728	STAD	TCGA	SKENI	DEG_APCC_KENBOX_2	268:272	Mutation rewiring degron network	0.1944
p.Q277E	DO38619	STAD	ICGC	SKENI	DEG_APCC_KENBOX_2	268:272	Mutation rewiring degron network	0.1944
p.P178H	TCGA-D8-A1JK	BRCA	TCGA	PPMY	ITCH	167:170	Mutation rewiring degron network	0.1111
p.P178H	DO3880	BRCA	ICGC	PPMY	ITCH	167:170	Mutation rewiring degron network	0.1111
p.L137F	TCGA-DF-A2KV	UCEC	TCGA	PKENK	DEG_APCC_KENBOX_2	129:133	Mutation rewiring degron network	0.2222
p.L137F	TCGA-FB-AAPP	PAAD	TCGA	PKENK	DEG_APCC_KENBOX_2	129:133	Mutation rewiring degron network	0.2222
p.L137F	DO218963	PAAD	ICGC	PKENK	DEG_APCC_KENBOX_2	129:133	Mutation rewiring degron network	0.2222
p.L137F	DO219771	UCEC	ICGC	PKENK	DEG_APCC_KENBOX_2	129:133	Mutation rewiring degron network	0.2222
p.E263K	TCGA-EE-A29M	SKCM	TCGA	SKENI	DEG_APCC_KENBOX_2	268:272	Mutation rewiring degron network	0.1944
p.E263K	DO37404	SKCM	ICGC	SKENI	DEG_APCC_KENBOX_2	268:272	Mutation rewiring degron network	0.1944
p.R159K	TCGA-F4-6460	COAD	TCGA	PPMY	ITCH	167:170	Mutation rewiring degron network	0.1111
p.R159K	DO8850	COAD	ICGC	PPMY	ITCH	167:170	Mutation rewiring degron network	0.1111
p.Y170H	TCGA-FS-A1ZZ	SKCM	TCGA	PPMY	ITCH	167:170	Mutation altering degron motif	0.7229
p.Y170H	DO37412	SKCM	ICGC	PPMY	ITCH	167:170	Mutation altering degron motif	0.7229
p.E101Q	TCGA-G2-A2EC	BLCA	TCGA	QKENG	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.1389
p.E101Q	DO651	BLCA	ICGC	QKENG	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.1389
p.V86I	TCGA-L5-A4OU	ESCA	TCGA	QKENG	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.2222
p.P129S	TCGA-UY-A8OB	BLCA	TCGA	PKENK	DEG_APCC_KENBOX_2	129:133	Mutation altering degron motif	0.5641
p.P129S	DO219037	BLCA	ICGC	PKENK	DEG_APCC_KENBOX_2	129:133	Mutation altering degron motif	0.5641
p.M169L	DO48386	BLCA	ICGC	PPMY	ITCH	167:170	Mutation altering degron motif	0.5999
p.K141T	DO233937	GACA	ICGC	PKENK	DEG_APCC_KENBOX_2	129:133	Mutation substituting flanking lysine	0.2222
p.Q277R	DO228592	LICA	ICGC	SKENI	DEG_APCC_KENBOX_2	268:272	Mutation rewiring degron network	0.1944
p.P125H	DO228974	LICA	ICGC	PKENK	DEG_APCC_KENBOX_2	129:133	Mutation rewiring degron network	0.2222
p.N173S	DO228894	LICA	ICGC	PPMY	ITCH	167:170	Mutation rewiring degron network	0.25
p.P125L	DO222578	MELA	ICGC	PKENK	DEG_APCC_KENBOX_2	129:133	Mutation rewiring degron network	0.2222
p.P178L	DO218697	ORCA	ICGC	PPMY	ITCH	167:170	Mutation rewiring degron network	0.1111
p.S104L	DO232057	ORCA	ICGC	QKENG	DEG_APCC_KENBOX_2	90:94	Mutation blocking phosphorylation signal	0.5
p.L99F	DO49143	PACA	ICGC	QKENG	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.1944
p.P87H	DO32976	PACA	ICGC	QKENG	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.25
p.V265A	DO228138	PBCA	ICGC	SKENI	DEG_APCC_KENBOX_2	268:272	Mutation rewiring degron network	0.25
p.S268R	DO232224	PBCA	ICGC	SKENI	DEG_APCC_KENBOX_2	268:272	Mutation altering degron motif	0.7427
p.D103N	DO218872	SKCA	ICGC	QKENG	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.0833
p.D280N	DO229502	SKCA	ICGC	SKENI	DEG_APCC_KENBOX_2	268:272	Mutation rewiring degron network	0.1111
p.I278M	SIDM02014	Esophageal Carcinoma	GDSC	SKENI	DEG_APCC_KENBOX_2	268:272	Mutation rewiring degron network	0.1667
p.I272T	SIDM00845	Burkitt's Lymphoma	GDSC	SKENI	DEG_APCC_KENBOX_2	268:272	Mutation altering degron motif	0.5966
p.S259T	SIDM00845	Burkitt's Lymphoma	GDSC	SKENI	DEG_APCC_KENBOX_2	268:272	Mutation rewiring degron network	0.0833
p.E124D	SIDM00645	Non-Small Cell Lung Carcinoma	GDSC	PKENK	DEG_APCC_KENBOX_2	129:133	Mutation rewiring degron network	0.1944
p.E124D	NCI-H1355	lung	COSMIC	PKENK	DEG_APCC_KENBOX_2	129:133	Mutation rewiring degron network	0.1944
p.M169V	SIDM00235	Kidney Carcinoma	GDSC	PPMY	ITCH	167:170	Mutation altering degron motif	0.6097
p.M169V	SIDM00381	Cervical Carcinoma	GDSC	PPMY	ITCH	167:170	Mutation altering degron motif	0.6097
p.M169V	SIDM01435	Hepatocellular Carcinoma	GDSC	PPMY	ITCH	167:170	Mutation altering degron motif	0.6097
p.M169V	SKG-IIIa	cervix	COSMIC	PPMY	ITCH	167:170	Mutation altering degron motif	0.6097
p.M169V	RCC10RGB	kidney	COSMIC	PPMY	ITCH	167:170	Mutation altering degron motif	0.6097
p.L99W	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	QKENG	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.1944
p.L99W	ACH-000945	Lung Cancer	CCLE	QKENG	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.1944
p.L99W	NCI-H650	lung	COSMIC	QKENG	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.1944
p.A136V	SIDM00498	Colorectal Carcinoma	GDSC	PKENK	DEG_APCC_KENBOX_2	129:133	Mutation rewiring degron network	0.25
p.A136V	ACH-000970	Colon/Colorectal Cancer	CCLE	PKENK	DEG_APCC_KENBOX_2	129:133	Mutation rewiring degron network	0.25
p.A136V	SNU-C5	large intestine	COSMIC	PKENK	DEG_APCC_KENBOX_2	129:133	Mutation rewiring degron network	0.25
p.P134L	ACH-000774	Lung Cancer	CCLE	PKENK	DEG_APCC_KENBOX_2	129:133	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SCG2

UniProt ID: P13521

Entrez ID: 7857

Protein name: Secretogranin-2 (Chromogranin-C) (Secretogranin II) (SgII) [Cleaved into: Secretoneurin (SN); Manserin]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SCG2 in