DegronMD

Uniprot ID: P13521

Source protein: Secretogranin-2

Source gene: SCG2

Class: DEG_APCC_KENBOX_2

Location: 90:94

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9394

ASA_SCORE: 99.3

COIL: 0.7328

CONS_SCORE: 0.5631

DSS_SCORE: 0.7068

HELIX: 0.2492

FCONS_SCORE: 1.0183

RIG_SCORE: 0.6064

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y81C	TCGA-28-1747	GBM	TCGA	QKENG	DEG_APCC_KENBOX_2	0.0833
p.Y81C	DO13096	GBM	ICGC	QKENG	DEG_APCC_KENBOX_2	0.0833
p.Q82E	TCGA-95-7043	LUAD	TCGA	QKENG	DEG_APCC_KENBOX_2	0.1111
p.Q82E	TCGA-IR-A3LL	CESC	TCGA	QKENG	DEG_APCC_KENBOX_2	0.1111
p.Q82E	DO44362	CESC	ICGC	QKENG	DEG_APCC_KENBOX_2	0.1111
p.Q82E	DO24739	LUAD	ICGC	QKENG	DEG_APCC_KENBOX_2	0.1111
p.D95N	TCGA-AG-3892	READ	TCGA	QKENG	DEG_APCC_KENBOX_2	0.3056
p.D95N	TCGA-CD-8528	STAD	TCGA	QKENG	DEG_APCC_KENBOX_2	0.3056
p.D95N	DO222765	COCA	ICGC	QKENG	DEG_APCC_KENBOX_2	0.3056
p.D95N	DO28763	OV	ICGC	QKENG	DEG_APCC_KENBOX_2	0.3056
p.D95N	DO36394	READ	ICGC	QKENG	DEG_APCC_KENBOX_2	0.3056
p.D95N	DO47729	STAD	ICGC	QKENG	DEG_APCC_KENBOX_2	0.3056
p.E101Q	TCGA-G2-A2EC	BLCA	TCGA	QKENG	DEG_APCC_KENBOX_2	0.1389
p.E101Q	DO651	BLCA	ICGC	QKENG	DEG_APCC_KENBOX_2	0.1389
p.V86I	TCGA-L5-A4OU	ESCA	TCGA	QKENG	DEG_APCC_KENBOX_2	0.2222
p.S104L	DO232057	ORCA	ICGC	QKENG	DEG_APCC_KENBOX_2	0.5
p.L99F	DO49143	PACA	ICGC	QKENG	DEG_APCC_KENBOX_2	0.1944
p.P87H	DO32976	PACA	ICGC	QKENG	DEG_APCC_KENBOX_2	0.25
p.D103N	DO218872	SKCA	ICGC	QKENG	DEG_APCC_KENBOX_2	0.0833
p.L99W	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	QKENG	DEG_APCC_KENBOX_2	0.1944
p.L99W	ACH-000945	Lung Cancer	CCLE	QKENG	DEG_APCC_KENBOX_2	0.1944
p.L99W	NCI-H650	lung	COSMIC	QKENG	DEG_APCC_KENBOX_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14672	Disintegrin and metalloproteinase domain-containing protein 10	DEG_APCC_KENBOX_2	409:413	QKENG	APC,CDC20,FZR1	0.981	More...
P13521	Secretogranin-2	DEG_APCC_KENBOX_2	90:94	QKENG	APC,CDC20,FZR1	0.9394	More...
P24752	Acetyl-CoA acetyltransferase, mitochondrial	DEG_APCC_KENBOX_2	272:276	QKENG	APC,CDC20,FZR1	0.8509	More...
Q15047	Histone-lysine N-methyltransferase SETDB1	DEG_APCC_KENBOX_2	934:938	QKENG	APC,CDC20,FZR1	0.7114	More...
Q8N3A8	Protein mono-ADP-ribosyltransferase PARP8	DEG_APCC_KENBOX_2	110:114	QKENG	APC,CDC20,FZR1	0.6058	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons