DegronMD

Uniprot ID: Q15047

Source protein: Histone-lysine N-methyltransferase SETDB1

Source gene: SETDB1

Class: DEG_APCC_KENBOX_2

Location: 934:938

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7114

ASA_SCORE: 105.7

COIL: 0.807

CONS_SCORE: 0.3958

DSS_SCORE: 0.7275

HELIX: 0.1478

FCONS_SCORE: 1.0157

RIG_SCORE: 0.5922

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T943I	TCGA-A6-2684	COAD	TCGA	QKENG	DEG_APCC_KENBOX_2	0.1944
p.T943I	DO10236	COAD	ICGC	QKENG	DEG_APCC_KENBOX_2	0.1944
p.S940F	TCGA-MN-A4N4	LUAD	TCGA	QKENG	DEG_APCC_KENBOX_2	0.2778
p.S940F	DO26250	LUAD	ICGC	QKENG	DEG_APCC_KENBOX_2	0.2778
p.R932Q	TCGA-N5-A4RO	UCS	TCGA	QKENG	DEG_APCC_KENBOX_2	0.2778
p.G933S	TCGA-W3-AA1R	SKCM	TCGA	QKENG	DEG_APCC_KENBOX_2	0.3056
p.G933S	DO51275	SKCM	ICGC	QKENG	DEG_APCC_KENBOX_2	0.3056
p.R932W	DO222769	COCA	ICGC	QKENG	DEG_APCC_KENBOX_2	0.2778
p.R928Q	DO233617	GACA	ICGC	QKENG	DEG_APCC_KENBOX_2	0.1667
p.Q930H	DO229045	LICA	ICGC	QKENG	DEG_APCC_KENBOX_2	0.2222
p.Q930H	SIDM00958	Chronic Myelogenous Leukemia	GDSC	QKENG	DEG_APCC_KENBOX_2	0.2222
p.Q930H	ACH-000920	Leukemia	CCLE	QKENG	DEG_APCC_KENBOX_2	0.2222
p.Q930H	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	QKENG	DEG_APCC_KENBOX_2	0.2222
p.T927P	DO45049	LINC	ICGC	QKENG	DEG_APCC_KENBOX_2	0.1389
p.H948R	SIDM00845	Burkitt's Lymphoma	GDSC	QKENG	DEG_APCC_KENBOX_2	0.0556
p.N937D	SIDM01263	T-Lymphoblastic Leukemia	GDSC	QKENG	DEG_APCC_KENBOX_2	0.6932

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14672	Disintegrin and metalloproteinase domain-containing protein 10	DEG_APCC_KENBOX_2	409:413	QKENG	APC,CDC20,FZR1	0.981	More...
P13521	Secretogranin-2	DEG_APCC_KENBOX_2	90:94	QKENG	APC,CDC20,FZR1	0.9394	More...
P24752	Acetyl-CoA acetyltransferase, mitochondrial	DEG_APCC_KENBOX_2	272:276	QKENG	APC,CDC20,FZR1	0.8509	More...
Q15047	Histone-lysine N-methyltransferase SETDB1	DEG_APCC_KENBOX_2	934:938	QKENG	APC,CDC20,FZR1	0.7114	More...
Q8N3A8	Protein mono-ADP-ribosyltransferase PARP8	DEG_APCC_KENBOX_2	110:114	QKENG	APC,CDC20,FZR1	0.6058	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons