DegronMD - Q8N3A8(PARP8)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S435N	TCGA-44-2656	LUAD	TCGA	KTELFKE	LIG_APCC_ABBAyCdc20_2	441:447	Mutation rewiring degron network	0.1667
p.S435N	DO26052	LUAD	ICGC	KTELFKE	LIG_APCC_ABBAyCdc20_2	441:447	Mutation rewiring degron network	0.1667
p.I462T	TCGA-56-7730	LUSC	TCGA	ILTPSSS	DEG_SCF_FBW7_1	464:470	Mutation rewiring degron network	0.2778
p.I462T	DO26617	LUSC	ICGC	ILTPSSS	DEG_SCF_FBW7_1	464:470	Mutation rewiring degron network	0.2778
p.A436T	TCGA-AA-A010	COAD	TCGA	KTELFKE	LIG_APCC_ABBAyCdc20_2	441:447	Mutation rewiring degron network	0.1944
p.K111T	TCGA-AN-A046	BRCA	TCGA	QKENG	DEG_APCC_KENBOX_2	110:114	Mutation altering degron motif	0.7306
p.K111T	DO1285	BRCA	ICGC	QKENG	DEG_APCC_KENBOX_2	110:114	Mutation altering degron motif	0.7306
p.P467Q	TCGA-AX-A1CE	UCEC	TCGA	ILTPSSS	DEG_SCF_FBW7_1	464:470	Mutation altering degron motif	0.7035
p.P467Q	DO42280	UCEC	ICGC	ILTPSSS	DEG_SCF_FBW7_1	464:470	Mutation altering degron motif	0.7035
p.R454K	TCGA-B5-A3FC	UCEC	TCGA	ILTPSSS	DEG_SCF_FBW7_1	464:470	Mutation rewiring degron network	0.0556
p.R454K	TCGA-B5-A3FC	UCEC	TCGA	KTELFKE	LIG_APCC_ABBAyCdc20_2	441:447	Mutation rewiring degron network	0.1389
p.R454K	DO41871	UCEC	ICGC	ILTPSSS	DEG_SCF_FBW7_1	464:470	Mutation rewiring degron network	0.0556
p.R454K	DO41871	UCEC	ICGC	KTELFKE	LIG_APCC_ABBAyCdc20_2	441:447	Mutation rewiring degron network	0.1389
p.E112K	TCGA-BF-AAP2	SKCM	TCGA	QKENG	DEG_APCC_KENBOX_2	110:114	Mutation altering degron motif	0.7022
p.E112K	TCGA-D3-A3ML	SKCM	TCGA	QKENG	DEG_APCC_KENBOX_2	110:114	Mutation altering degron motif	0.7022
p.E112K	DO222595	MELA	ICGC	QKENG	DEG_APCC_KENBOX_2	110:114	Mutation altering degron motif	0.7022
p.E112K	DO222546	MELA	ICGC	QKENG	DEG_APCC_KENBOX_2	110:114	Mutation altering degron motif	0.7022
p.E112K	DO47413	SKCM	ICGC	QKENG	DEG_APCC_KENBOX_2	110:114	Mutation altering degron motif	0.7022
p.E112K	DO219466	SKCM	ICGC	QKENG	DEG_APCC_KENBOX_2	110:114	Mutation altering degron motif	0.7022
p.S468C	TCGA-CN-A6V1	HNSC	TCGA	ILTPSSS	DEG_SCF_FBW7_1	464:470	Mutation altering degron motif	0.643
p.S468C	DO52048	HNSC	ICGC	ILTPSSS	DEG_SCF_FBW7_1	464:470	Mutation altering degron motif	0.643
p.E443Q	TCGA-CV-A463	HNSC	TCGA	KTELFKE	LIG_APCC_ABBAyCdc20_2	441:447	Mutation altering degron motif	0.5633
p.E443Q	DO52066	HNSC	ICGC	KTELFKE	LIG_APCC_ABBAyCdc20_2	441:447	Mutation altering degron motif	0.5633
p.K446N	TCGA-D3-A2JC	SKCM	TCGA	KTELFKE	LIG_APCC_ABBAyCdc20_2	441:447	Mutation altering degron motif	0.5806
p.K446N	DO47578	SKCM	ICGC	KTELFKE	LIG_APCC_ABBAyCdc20_2	441:447	Mutation altering degron motif	0.5806
p.K446N	SIDM00747	Non-Small Cell Lung Carcinoma	GDSC	KTELFKE	LIG_APCC_ABBAyCdc20_2	441:447	Mutation altering degron motif	0.5806
p.K446N	ACH-000744	Lung Cancer	CCLE	KTELFKE	LIG_APCC_ABBAyCdc20_2	441:447	Mutation altering degron motif	0.5806
p.K446N	NCI-H1623	lung	COSMIC	KTELFKE	LIG_APCC_ABBAyCdc20_2	441:447	Mutation altering degron motif	0.5806
p.S471L	TCGA-DA-A1I4	SKCM	TCGA	ILTPSSS	DEG_SCF_FBW7_1	464:470	Mutation rewiring degron network	0.3056
p.S471L	DO37655	SKCM	ICGC	ILTPSSS	DEG_SCF_FBW7_1	464:470	Mutation rewiring degron network	0.3056
p.S473F	TCGA-DC-5869	READ	TCGA	ILTPSSS	DEG_SCF_FBW7_1	464:470	Mutation rewiring degron network	0.25
p.S473F	DO36584	READ	ICGC	ILTPSSS	DEG_SCF_FBW7_1	464:470	Mutation rewiring degron network	0.25
p.I464V	TCGA-DD-AAE7	LIHC	TCGA	ILTPSSS	DEG_SCF_FBW7_1	464:470	Mutation altering degron motif	0.5965
p.I464V	DO52262	LIHC	ICGC	ILTPSSS	DEG_SCF_FBW7_1	464:470	Mutation altering degron motif	0.5965
p.A450T	TCGA-EY-A215	UCEC	TCGA	KTELFKE	LIG_APCC_ABBAyCdc20_2	441:447	Mutation rewiring degron network	0.25
p.A450T	DO42665	UCEC	ICGC	KTELFKE	LIG_APCC_ABBAyCdc20_2	441:447	Mutation rewiring degron network	0.25
p.A450T	SIDM00980	Gastric Carcinoma	GDSC	KTELFKE	LIG_APCC_ABBAyCdc20_2	441:447	Mutation rewiring degron network	0.25
p.A450T	SIDM01451	Pancreatic Carcinoma	GDSC	KTELFKE	LIG_APCC_ABBAyCdc20_2	441:447	Mutation rewiring degron network	0.25
p.A450T	ACH-000933	Pancreatic Cancer	CCLE	KTELFKE	LIG_APCC_ABBAyCdc20_2	441:447	Mutation rewiring degron network	0.25
p.A450T	ACH-000948	Gastric Cancer	CCLE	KTELFKE	LIG_APCC_ABBAyCdc20_2	441:447	Mutation rewiring degron network	0.25
p.A450T	23132-87	stomach	COSMIC	KTELFKE	LIG_APCC_ABBAyCdc20_2	441:447	Mutation rewiring degron network	0.25
p.S439L	TCGA-FD-A3SO	BLCA	TCGA	KTELFKE	LIG_APCC_ABBAyCdc20_2	441:447	Mutation rewiring degron network	0.2778
p.S439L	DO569	BLCA	ICGC	KTELFKE	LIG_APCC_ABBAyCdc20_2	441:447	Mutation rewiring degron network	0.2778
p.E116K	TCGA-GN-A266	SKCM	TCGA	QKENG	DEG_APCC_KENBOX_2	110:114	Mutation rewiring degron network	0.2778
p.E116K	DO37432	SKCM	ICGC	QKENG	DEG_APCC_KENBOX_2	110:114	Mutation rewiring degron network	0.2778
p.L444F	TCGA-IB-7651	PAAD	TCGA	KTELFKE	LIG_APCC_ABBAyCdc20_2	441:447	Mutation altering degron motif	0.6981
p.L444F	DO46657	PAAD	ICGC	KTELFKE	LIG_APCC_ABBAyCdc20_2	441:447	Mutation altering degron motif	0.6981
p.K438M	TCGA-UY-A9PE	BLCA	TCGA	KTELFKE	LIG_APCC_ABBAyCdc20_2	441:447	Mutation substituting flanking lysine	0.3611
p.K438M	DO219043	BLCA	ICGC	KTELFKE	LIG_APCC_ABBAyCdc20_2	441:447	Mutation substituting flanking lysine	0.3611
p.E124D	DO229029	LICA	ICGC	QKENG	DEG_APCC_KENBOX_2	110:114	Mutation rewiring degron network	0.0556
p.K438N	DO229036	LICA	ICGC	KTELFKE	LIG_APCC_ABBAyCdc20_2	441:447	Mutation substituting flanking lysine	0.3611
p.Q109K	DO229465	SKCA	ICGC	QKENG	DEG_APCC_KENBOX_2	110:114	Mutation rewiring degron network	0.3056
p.N100K	DO229264	THCA	ICGC	QKENG	DEG_APCC_KENBOX_2	110:114	Mutation rewiring degron network	0.0556
p.R118I	SIDM01095	Rhabdomyosarcoma	GDSC	QKENG	DEG_APCC_KENBOX_2	110:114	Mutation rewiring degron network	0.2222
p.R118I	ACH-000833	Sarcoma	CCLE	QKENG	DEG_APCC_KENBOX_2	110:114	Mutation rewiring degron network	0.2222
p.R118I	SJRH30	soft tissue	COSMIC	QKENG	DEG_APCC_KENBOX_2	110:114	Mutation rewiring degron network	0.2222
p.T122S	SIDM00537	Colorectal Carcinoma	GDSC	QKENG	DEG_APCC_KENBOX_2	110:114	Mutation rewiring degron network	0.1111
p.T122S	ACH-001345	Colon/Colorectal Cancer	CCLE	QKENG	DEG_APCC_KENBOX_2	110:114	Mutation rewiring degron network	0.1111
p.T122S	GP5d	large intestine	COSMIC	QKENG	DEG_APCC_KENBOX_2	110:114	Mutation rewiring degron network	0.1111
p.Q474H	SIDM00534	Colorectal Carcinoma	GDSC	ILTPSSS	DEG_SCF_FBW7_1	464:470	Mutation rewiring degron network	0.2222
p.Q474H	ACH-000986	Colon/Colorectal Cancer	CCLE	ILTPSSS	DEG_SCF_FBW7_1	464:470	Mutation rewiring degron network	0.2222
p.Q474H	HT-115	large intestine	COSMIC	ILTPSSS	DEG_SCF_FBW7_1	464:470	Mutation rewiring degron network	0.2222
p.S104F	SIDM00225	Melanoma	GDSC	QKENG	DEG_APCC_KENBOX_2	110:114	Mutation blocking phosphorylation signal	0.6111
p.S104F	ACH-002143	Skin Cancer	CCLE	QKENG	DEG_APCC_KENBOX_2	110:114	Mutation blocking phosphorylation signal	0.6111
p.S104F	IST-MEL1	skin	COSMIC	QKENG	DEG_APCC_KENBOX_2	110:114	Mutation blocking phosphorylation signal	0.6111
p.P477S	SIDM01750	Melanoma	GDSC	ILTPSSS	DEG_SCF_FBW7_1	464:470	Mutation rewiring degron network	0.1389
p.S435R	ACH-000629	Brain Cancer	CCLE	KTELFKE	LIG_APCC_ABBAyCdc20_2	441:447	Mutation rewiring degron network	0.1667
p.S468T	ACH-002287	Colon/Colorectal Cancer	CCLE	ILTPSSS	DEG_SCF_FBW7_1	464:470	Mutation altering degron motif	0.6005
p.S468T	NCI-H630	large intestine	COSMIC	ILTPSSS	DEG_SCF_FBW7_1	464:470	Mutation altering degron motif	0.6005
p.G439A	OSC-20	upper aerodigestive tract	COSMIC	KTELFKE	LIG_APCC_ABBAyCdc20_2	441:447	Mutation rewiring degron network	0.2778
p.S447T	NCI-H630	large intestine	COSMIC	KTELFKE	LIG_APCC_ABBAyCdc20_2	441:447	Mutation altering degron motif	0.7116
p.Q453H	HT-115	large intestine	COSMIC	KTELFKE	LIG_APCC_ABBAyCdc20_2	441:447	Mutation rewiring degron network	0.1667
p.P469T	HCT-15	large intestine	COSMIC	ILTPSSS	DEG_SCF_FBW7_1	464:470	Mutation altering degron motif	0.7031
p.C461Y	DU-145	prostate	COSMIC	ILTPSSS	DEG_SCF_FBW7_1	464:470	Mutation rewiring degron network	0.25
p.P446S	SW684	soft tissue	COSMIC	KTELFKE	LIG_APCC_ABBAyCdc20_2	441:447	Mutation altering degron motif	0.6752
p.T101S	GP5d	large intestine	COSMIC	QKENG	DEG_APCC_KENBOX_2	110:114	Mutation rewiring degron network	0.0833
p.D467Y	NCI-H1793	lung	COSMIC	ILTPSSS	DEG_SCF_FBW7_1	464:470	Mutation altering degron motif	0.7325
p.P119S	OV-56	ovary	COSMIC	QKENG	DEG_APCC_KENBOX_2	110:114	Mutation rewiring degron network	0.1944
p.D467H	NCI-H2126	lung	COSMIC	ILTPSSS	DEG_SCF_FBW7_1	464:470	Mutation altering degron motif	0.7688

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PARP8

UniProt ID: Q8N3A8

Entrez ID: 79668

Protein name: Protein mono-ADP-ribosyltransferase PARP8 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 16) (ARTD16) (Poly [ADP-ribose] polymerase 8) (PARP-8)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PARP8 in