DegronMD

Uniprot ID: Q8N3A8

Source protein: Protein mono-ADP-ribosyltransferase PARP8

Source gene: PARP8

Class: LIG_APCC_ABBAyCdc20_2

Location: 441:447

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5184

ASA_SCORE: 78.5

COIL: 0.5336

CONS_SCORE: 0.298

DSS_SCORE: 0.5557

HELIX: 0.3254

FCONS_SCORE: 0.9068

RIG_SCORE: 0.7341

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S435N	TCGA-44-2656	LUAD	TCGA	KTELFKE	LIG_APCC_ABBAyCdc20_2	0.1667
p.S435N	DO26052	LUAD	ICGC	KTELFKE	LIG_APCC_ABBAyCdc20_2	0.1667
p.A436T	TCGA-AA-A010	COAD	TCGA	KTELFKE	LIG_APCC_ABBAyCdc20_2	0.1944
p.R454K	TCGA-B5-A3FC	UCEC	TCGA	KTELFKE	LIG_APCC_ABBAyCdc20_2	0.1389
p.R454K	DO41871	UCEC	ICGC	KTELFKE	LIG_APCC_ABBAyCdc20_2	0.1389
p.E443Q	TCGA-CV-A463	HNSC	TCGA	KTELFKE	LIG_APCC_ABBAyCdc20_2	0.5633
p.E443Q	DO52066	HNSC	ICGC	KTELFKE	LIG_APCC_ABBAyCdc20_2	0.5633
p.K446N	TCGA-D3-A2JC	SKCM	TCGA	KTELFKE	LIG_APCC_ABBAyCdc20_2	0.5806
p.K446N	DO47578	SKCM	ICGC	KTELFKE	LIG_APCC_ABBAyCdc20_2	0.5806
p.K446N	SIDM00747	Non-Small Cell Lung Carcinoma	GDSC	KTELFKE	LIG_APCC_ABBAyCdc20_2	0.5806
p.K446N	ACH-000744	Lung Cancer	CCLE	KTELFKE	LIG_APCC_ABBAyCdc20_2	0.5806
p.K446N	NCI-H1623	lung	COSMIC	KTELFKE	LIG_APCC_ABBAyCdc20_2	0.5806
p.A450T	TCGA-EY-A215	UCEC	TCGA	KTELFKE	LIG_APCC_ABBAyCdc20_2	0.25
p.A450T	DO42665	UCEC	ICGC	KTELFKE	LIG_APCC_ABBAyCdc20_2	0.25
p.A450T	SIDM00980	Gastric Carcinoma	GDSC	KTELFKE	LIG_APCC_ABBAyCdc20_2	0.25
p.A450T	SIDM01451	Pancreatic Carcinoma	GDSC	KTELFKE	LIG_APCC_ABBAyCdc20_2	0.25
p.A450T	ACH-000933	Pancreatic Cancer	CCLE	KTELFKE	LIG_APCC_ABBAyCdc20_2	0.25
p.A450T	ACH-000948	Gastric Cancer	CCLE	KTELFKE	LIG_APCC_ABBAyCdc20_2	0.25
p.A450T	23132-87	stomach	COSMIC	KTELFKE	LIG_APCC_ABBAyCdc20_2	0.25
p.S439L	TCGA-FD-A3SO	BLCA	TCGA	KTELFKE	LIG_APCC_ABBAyCdc20_2	0.2778
p.S439L	DO569	BLCA	ICGC	KTELFKE	LIG_APCC_ABBAyCdc20_2	0.2778
p.L444F	TCGA-IB-7651	PAAD	TCGA	KTELFKE	LIG_APCC_ABBAyCdc20_2	0.6981
p.L444F	DO46657	PAAD	ICGC	KTELFKE	LIG_APCC_ABBAyCdc20_2	0.6981
p.K438M	TCGA-UY-A9PE	BLCA	TCGA	KTELFKE	LIG_APCC_ABBAyCdc20_2	0.3611
p.K438M	DO219043	BLCA	ICGC	KTELFKE	LIG_APCC_ABBAyCdc20_2	0.3611
p.K438N	DO229036	LICA	ICGC	KTELFKE	LIG_APCC_ABBAyCdc20_2	0.3611
p.S435R	ACH-000629	Brain Cancer	CCLE	KTELFKE	LIG_APCC_ABBAyCdc20_2	0.1667
p.G439A	OSC-20	upper_aerodigestive_tract	COSMIC	KTELFKE	LIG_APCC_ABBAyCdc20_2	0.2778
p.S447T	NCI-H630	large_intestine	COSMIC	KTELFKE	LIG_APCC_ABBAyCdc20_2	0.7116
p.Q453H	HT-115	large_intestine	COSMIC	KTELFKE	LIG_APCC_ABBAyCdc20_2	0.1667
p.P446S	SW684	soft_tissue	COSMIC	KTELFKE	LIG_APCC_ABBAyCdc20_2	0.6752

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KTELFKE

Degron related mutations and impact score

Drug responses associated with PARP8 mutations

All proteins holding degron of KTELFKE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N3A8	Protein mono-ADP-ribosyltransferase PARP8	LIG_APCC_ABBAyCdc20_2	441:447	KTELFKE	APC,CDC20,FZR1	0.5184	More...