DegronMD

Uniprot ID: Q8N3A8

Source protein: Protein mono-ADP-ribosyltransferase PARP8

Source gene: PARP8

Class: DEG_APCC_KENBOX_2

Location: 110:114

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6058

ASA_SCORE: 103.76

COIL: 0.5874

CONS_SCORE: 0.4418

DSS_SCORE: 0.5026

HELIX: 0.4034

FCONS_SCORE: 1.1695

RIG_SCORE: 0.6586

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K111T	TCGA-AN-A046	BRCA	TCGA	QKENG	DEG_APCC_KENBOX_2	0.7306
p.K111T	DO1285	BRCA	ICGC	QKENG	DEG_APCC_KENBOX_2	0.7306
p.E112K	TCGA-BF-AAP2	SKCM	TCGA	QKENG	DEG_APCC_KENBOX_2	0.7022
p.E112K	TCGA-D3-A3ML	SKCM	TCGA	QKENG	DEG_APCC_KENBOX_2	0.7022
p.E112K	DO222595	MELA	ICGC	QKENG	DEG_APCC_KENBOX_2	0.7022
p.E112K	DO222546	MELA	ICGC	QKENG	DEG_APCC_KENBOX_2	0.7022
p.E112K	DO47413	SKCM	ICGC	QKENG	DEG_APCC_KENBOX_2	0.7022
p.E112K	DO219466	SKCM	ICGC	QKENG	DEG_APCC_KENBOX_2	0.7022
p.E116K	TCGA-GN-A266	SKCM	TCGA	QKENG	DEG_APCC_KENBOX_2	0.2778
p.E116K	DO37432	SKCM	ICGC	QKENG	DEG_APCC_KENBOX_2	0.2778
p.E124D	DO229029	LICA	ICGC	QKENG	DEG_APCC_KENBOX_2	0.0556
p.Q109K	DO229465	SKCA	ICGC	QKENG	DEG_APCC_KENBOX_2	0.3056
p.N100K	DO229264	THCA	ICGC	QKENG	DEG_APCC_KENBOX_2	0.0556
p.R118I	SIDM01095	Rhabdomyosarcoma	GDSC	QKENG	DEG_APCC_KENBOX_2	0.2222
p.R118I	ACH-000833	Sarcoma	CCLE	QKENG	DEG_APCC_KENBOX_2	0.2222
p.R118I	SJRH30	soft_tissue	COSMIC	QKENG	DEG_APCC_KENBOX_2	0.2222
p.T122S	SIDM00537	Colorectal Carcinoma	GDSC	QKENG	DEG_APCC_KENBOX_2	0.1111
p.T122S	ACH-001345	Colon/Colorectal Cancer	CCLE	QKENG	DEG_APCC_KENBOX_2	0.1111
p.T122S	GP5d	large_intestine	COSMIC	QKENG	DEG_APCC_KENBOX_2	0.1111
p.S104F	SIDM00225	Melanoma	GDSC	QKENG	DEG_APCC_KENBOX_2	0.6111
p.S104F	ACH-002143	Skin Cancer	CCLE	QKENG	DEG_APCC_KENBOX_2	0.6111
p.S104F	IST-MEL1	skin	COSMIC	QKENG	DEG_APCC_KENBOX_2	0.6111
p.T101S	GP5d	large_intestine	COSMIC	QKENG	DEG_APCC_KENBOX_2	0.0833
p.P119S	OV-56	ovary	COSMIC	QKENG	DEG_APCC_KENBOX_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14672	Disintegrin and metalloproteinase domain-containing protein 10	DEG_APCC_KENBOX_2	409:413	QKENG	APC,CDC20,FZR1	0.981	More...
P13521	Secretogranin-2	DEG_APCC_KENBOX_2	90:94	QKENG	APC,CDC20,FZR1	0.9394	More...
P24752	Acetyl-CoA acetyltransferase, mitochondrial	DEG_APCC_KENBOX_2	272:276	QKENG	APC,CDC20,FZR1	0.8509	More...
Q15047	Histone-lysine N-methyltransferase SETDB1	DEG_APCC_KENBOX_2	934:938	QKENG	APC,CDC20,FZR1	0.7114	More...
Q8N3A8	Protein mono-ADP-ribosyltransferase PARP8	DEG_APCC_KENBOX_2	110:114	QKENG	APC,CDC20,FZR1	0.6058	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons