DegronMD

Uniprot ID: P24752

Source protein: Acetyl-CoA acetyltransferase, mitochondrial

Source gene: ACAT1

Class: DEG_APCC_KENBOX_2

Location: 272:276

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8509

ASA_SCORE: 87.56

COIL: 0.7954

CONS_SCORE: 0.5482

DSS_SCORE: 0.3051

HELIX: 0.025

FCONS_SCORE: 0.8187

RIG_SCORE: 0.7801

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A283D	TCGA-FI-A2D6	UCEC	TCGA	QKENG	DEG_APCC_KENBOX_2	0.1389
p.A283D	DO43867	UCEC	ICGC	QKENG	DEG_APCC_KENBOX_2	0.1389
p.T269A	DO230326	COCA	ICGC	QKENG	DEG_APCC_KENBOX_2	0.25
p.S262I	DO229015	LICA	ICGC	QKENG	DEG_APCC_KENBOX_2	0.5
p.G276V	DO229006	LICA	ICGC	QKENG	DEG_APCC_KENBOX_2	0.6421
p.N282S	DO33968	PACA	ICGC	QKENG	DEG_APCC_KENBOX_2	0.1667
p.S284N	DO232224	PBCA	ICGC	QKENG	DEG_APCC_KENBOX_2	0.1111
p.T285S	DO233470	PRAD	ICGC	QKENG	DEG_APCC_KENBOX_2	0.5278

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14672	Disintegrin and metalloproteinase domain-containing protein 10	DEG_APCC_KENBOX_2	409:413	QKENG	APC,CDC20,FZR1	0.981	More...
P13521	Secretogranin-2	DEG_APCC_KENBOX_2	90:94	QKENG	APC,CDC20,FZR1	0.9394	More...
P24752	Acetyl-CoA acetyltransferase, mitochondrial	DEG_APCC_KENBOX_2	272:276	QKENG	APC,CDC20,FZR1	0.8509	More...
Q15047	Histone-lysine N-methyltransferase SETDB1	DEG_APCC_KENBOX_2	934:938	QKENG	APC,CDC20,FZR1	0.7114	More...
Q8N3A8	Protein mono-ADP-ribosyltransferase PARP8	DEG_APCC_KENBOX_2	110:114	QKENG	APC,CDC20,FZR1	0.6058	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons