DegronMD

Uniprot ID: O14672

Source protein: Disintegrin and metalloproteinase domain-containing protein 10

Source gene: ADAM10

Class: DEG_APCC_KENBOX_2

Location: 409:413

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.981

ASA_SCORE: 81.02

COIL: 0.7776

CONS_SCORE: 0.445

DSS_SCORE: 0.4755

HELIX: 0.1044

FCONS_SCORE: 0.7729

RIG_SCORE: 0.7155

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E403K	TCGA-CG-5734	STAD	TCGA	QKENG	DEG_APCC_KENBOX_2	0.1667
p.E403K	DO38265	STAD	ICGC	QKENG	DEG_APCC_KENBOX_2	0.1667
p.S423F	TCGA-DK-A2I1	BLCA	TCGA	QKENG	DEG_APCC_KENBOX_2	0.0556
p.S423F	DO444	BLCA	ICGC	QKENG	DEG_APCC_KENBOX_2	0.0556
p.P401L	TCGA-G4-6297	COAD	TCGA	QKENG	DEG_APCC_KENBOX_2	0.1111
p.P401L	DO9418	COAD	ICGC	QKENG	DEG_APCC_KENBOX_2	0.1111
p.E403Q	TCGA-IR-A3LL	CESC	TCGA	QKENG	DEG_APCC_KENBOX_2	0.1667
p.E403Q	DO44362	CESC	ICGC	QKENG	DEG_APCC_KENBOX_2	0.1667
p.P401T	DO228976	LICA	ICGC	QKENG	DEG_APCC_KENBOX_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14672	Disintegrin and metalloproteinase domain-containing protein 10	DEG_APCC_KENBOX_2	409:413	QKENG	APC,CDC20,FZR1	0.981	More...
P13521	Secretogranin-2	DEG_APCC_KENBOX_2	90:94	QKENG	APC,CDC20,FZR1	0.9394	More...
P24752	Acetyl-CoA acetyltransferase, mitochondrial	DEG_APCC_KENBOX_2	272:276	QKENG	APC,CDC20,FZR1	0.8509	More...
Q15047	Histone-lysine N-methyltransferase SETDB1	DEG_APCC_KENBOX_2	934:938	QKENG	APC,CDC20,FZR1	0.7114	More...
Q8N3A8	Protein mono-ADP-ribosyltransferase PARP8	DEG_APCC_KENBOX_2	110:114	QKENG	APC,CDC20,FZR1	0.6058	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons