DegronMD

Uniprot ID: Q8N3A8

Source protein: Protein mono-ADP-ribosyltransferase PARP8

Source gene: PARP8

Class: DEG_SCF_FBW7_1

Location: 464:470

E3 ligase: FBXW7

DEGRON score: 0.9224

ASA_SCORE: 63.3714

COIL: 0.7803

CONS_SCORE: 0.2962

DSS_SCORE: 0.4366

HELIX: 0.0934

FCONS_SCORE: 0.8582

RIG_SCORE: 0.6775

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I462T	TCGA-56-7730	LUSC	TCGA	ILTPSSS	DEG_SCF_FBW7_1	0.2778
p.I462T	DO26617	LUSC	ICGC	ILTPSSS	DEG_SCF_FBW7_1	0.2778
p.P467Q	TCGA-AX-A1CE	UCEC	TCGA	ILTPSSS	DEG_SCF_FBW7_1	0.7035
p.P467Q	DO42280	UCEC	ICGC	ILTPSSS	DEG_SCF_FBW7_1	0.7035
p.R454K	TCGA-B5-A3FC	UCEC	TCGA	ILTPSSS	DEG_SCF_FBW7_1	0.0556
p.R454K	DO41871	UCEC	ICGC	ILTPSSS	DEG_SCF_FBW7_1	0.0556
p.S468C	TCGA-CN-A6V1	HNSC	TCGA	ILTPSSS	DEG_SCF_FBW7_1	0.643
p.S468C	DO52048	HNSC	ICGC	ILTPSSS	DEG_SCF_FBW7_1	0.643
p.S471L	TCGA-DA-A1I4	SKCM	TCGA	ILTPSSS	DEG_SCF_FBW7_1	0.3056
p.S471L	DO37655	SKCM	ICGC	ILTPSSS	DEG_SCF_FBW7_1	0.3056
p.S473F	TCGA-DC-5869	READ	TCGA	ILTPSSS	DEG_SCF_FBW7_1	0.25
p.S473F	DO36584	READ	ICGC	ILTPSSS	DEG_SCF_FBW7_1	0.25
p.I464V	TCGA-DD-AAE7	LIHC	TCGA	ILTPSSS	DEG_SCF_FBW7_1	0.5965
p.I464V	DO52262	LIHC	ICGC	ILTPSSS	DEG_SCF_FBW7_1	0.5965
p.Q474H	SIDM00534	Colorectal Carcinoma	GDSC	ILTPSSS	DEG_SCF_FBW7_1	0.2222
p.Q474H	ACH-000986	Colon/Colorectal Cancer	CCLE	ILTPSSS	DEG_SCF_FBW7_1	0.2222
p.Q474H	HT-115	large_intestine	COSMIC	ILTPSSS	DEG_SCF_FBW7_1	0.2222
p.P477S	SIDM01750	Melanoma	GDSC	ILTPSSS	DEG_SCF_FBW7_1	0.1389
p.S468T	ACH-002287	Colon/Colorectal Cancer	CCLE	ILTPSSS	DEG_SCF_FBW7_1	0.6005
p.S468T	NCI-H630	large_intestine	COSMIC	ILTPSSS	DEG_SCF_FBW7_1	0.6005
p.P469T	HCT-15	large_intestine	COSMIC	ILTPSSS	DEG_SCF_FBW7_1	0.7031
p.C461Y	DU-145	prostate	COSMIC	ILTPSSS	DEG_SCF_FBW7_1	0.25
p.D467Y	NCI-H1793	lung	COSMIC	ILTPSSS	DEG_SCF_FBW7_1	0.7325
p.D467H	NCI-H2126	lung	COSMIC	ILTPSSS	DEG_SCF_FBW7_1	0.7688

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N3A8	Protein mono-ADP-ribosyltransferase PARP8	DEG_SCF_FBW7_1	464:470	ILTPSSS	FBXW7	0.9224	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons