DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PPMY
Uniprot ID:
P13521
Source protein:
Secretogranin-2
Source gene:
SCG2
Class:
ITCH
Location:
167:170
E3 ligase:
ITCH,NEDD4
DEGRON score:
0.519
ASA_SCORE:
96.975
COIL:
0.8498
CONS_SCORE:
0.6442
DSS_SCORE:
0.6105
HELIX:
0.0845
FCONS_SCORE:
1.0662
RIG_SCORE:
0.6867
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R159I
TCGA-A5-A0G2
UCEC
TCGA
PPMY
ITCH
0.1111
p.R159I
DO41235
UCEC
ICGC
PPMY
ITCH
0.1111
p.E172D
TCGA-A5-A2K5
UCEC
TCGA
PPMY
ITCH
0.2778
p.E172D
TCGA-EO-A3AY
UCEC
TCGA
PPMY
ITCH
0.2778
p.E172D
DO43202
UCEC
ICGC
PPMY
ITCH
0.2778
p.E172D
DO41379
UCEC
ICGC
PPMY
ITCH
0.2778
p.E172D
SIDM01588
Endometrial Carcinoma
GDSC
PPMY
ITCH
0.2778
p.E172D
ACH-000993
Endometrial/Uterine Cancer
CCLE
PPMY
ITCH
0.2778
p.P168S
TCGA-AG-A002
READ
TCGA
PPMY
ITCH
0.6752
p.P168S
TCGA-FJ-A3Z7
BLCA
TCGA
PPMY
ITCH
0.6752
p.P168S
DO463
BLCA
ICGC
PPMY
ITCH
0.6752
p.N177T
TCGA-AP-A1DK
UCEC
TCGA
PPMY
ITCH
0.1389
p.N177T
DO42033
UCEC
ICGC
PPMY
ITCH
0.1389
p.P178H
TCGA-D8-A1JK
BRCA
TCGA
PPMY
ITCH
0.1111
p.P178H
DO3880
BRCA
ICGC
PPMY
ITCH
0.1111
p.R159K
TCGA-F4-6460
COAD
TCGA
PPMY
ITCH
0.1111
p.R159K
DO8850
COAD
ICGC
PPMY
ITCH
0.1111
p.Y170H
TCGA-FS-A1ZZ
SKCM
TCGA
PPMY
ITCH
0.7229
p.Y170H
DO37412
SKCM
ICGC
PPMY
ITCH
0.7229
p.M169L
DO48386
BLCA
ICGC
PPMY
ITCH
0.5999
p.N173S
DO228894
LICA
ICGC
PPMY
ITCH
0.25
p.P178L
DO218697
ORCA
ICGC
PPMY
ITCH
0.1111
p.M169V
SIDM00235
Kidney Carcinoma
GDSC
PPMY
ITCH
0.6097
p.M169V
SIDM00381
Cervical Carcinoma
GDSC
PPMY
ITCH
0.6097
p.M169V
SIDM01435
Hepatocellular Carcinoma
GDSC
PPMY
ITCH
0.6097
p.M169V
SKG-IIIa
cervix
COSMIC
PPMY
ITCH
0.6097
p.M169V
RCC10RGB
kidney
COSMIC
PPMY
ITCH
0.6097
Drug responses associated with SCG2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PPMY
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P13521
Secretogranin-2
ITCH
167:170
PPMY
ITCH,NEDD4
0.519
More...
Q01954
Zinc finger protein basonuclin-1
ITCH
74:77
PPMY
ITCH,NEDD4
0.8829
More...
Q86VH2
Kinesin-like protein KIF27
ITCH
608:611
PPMY
ITCH,NEDD4
0.6139
More...
Q86WA8
Lon protease homolog 2, peroxisomal
ITCH
640:643
PPMY
ITCH,NEDD4
0.768
More...
Q96LT9
RNA-binding region-containing protein 3
ITCH
206:209
PPMY
ITCH,NEDD4
0.9928
More...
Q9HBD1
Roquin-2
ITCH
703:706
PPMY
ITCH,NEDD4
0.9939
More...
Q9HCF6
Transient receptor potential cation channel subfamily M member 3
ITCH
1515:1518
PPMY
ITCH,NEDD4
0.8817
More...
Q9NRJ4
Tubby-related protein 4
ITCH
1241:1244
PPMY
ITCH,NEDD4
0.769
More...
O15255
CAAX box protein 1
ITCH
94:97
PPMY
ITCH,NEDD4
0.956
More...
Q8NA69
Testis-expressed protein 45
ITCH
496:499
PPMY
ITCH,NEDD4
0.9984
More...
Q9P281
BAH and coiled-coil domain-containing protein 1
ITCH
901:904
PPMY
ITCH,NEDD4
0.9559
More...