DegronMD

Uniprot ID: Q8NA69

Source protein: Testis-expressed protein 45

Source gene: TEX45

Class: ITCH

Location: 496:499

E3 ligase: ITCH,NEDD4

DEGRON score: 0.9984

ASA_SCORE: 77

COIL: 0.8788

CONS_SCORE: 0.256

DSS_SCORE: 0.6449

HELIX: 0.0518

FCONS_SCORE: 0.9981

RIG_SCORE: 0.7428

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D490E	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	PPMY	ITCH	0.1667
p.D490E	PC-3_[JPC-3]	lung	COSMIC	PPMY	ITCH	0.1667

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P281	BAH and coiled-coil domain-containing protein 1	ITCH	901:904	PPMY	ITCH,NEDD4	0.9559	More...
O15255	CAAX box protein 1	ITCH	94:97	PPMY	ITCH,NEDD4	0.956	More...
Q86VH2	Kinesin-like protein KIF27	ITCH	608:611	PPMY	ITCH,NEDD4	0.6139	More...
Q86WA8	Lon protease homolog 2, peroxisomal	ITCH	640:643	PPMY	ITCH,NEDD4	0.768	More...
Q96LT9	RNA-binding region-containing protein 3	ITCH	206:209	PPMY	ITCH,NEDD4	0.9928	More...
Q9HBD1	Roquin-2	ITCH	703:706	PPMY	ITCH,NEDD4	0.9939	More...
P13521	Secretogranin-2	ITCH	167:170	PPMY	ITCH,NEDD4	0.519	More...
Q8NA69	Testis-expressed protein 45	ITCH	496:499	PPMY	ITCH,NEDD4	0.9984	More...
Q9HCF6	Transient receptor potential cation channel subfamily M member 3	ITCH	1515:1518	PPMY	ITCH,NEDD4	0.8817	More...
Q9NRJ4	Tubby-related protein 4	ITCH	1241:1244	PPMY	ITCH,NEDD4	0.769	More...
Q01954	Zinc finger protein basonuclin-1	ITCH	74:77	PPMY	ITCH,NEDD4	0.8829	More...

Showing 1 to 11 of 11 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons