DegronMD

Uniprot ID: Q9HBD1

Source protein: Roquin-2

Source gene: RC3H2

Class: ITCH

Location: 703:706

E3 ligase: ITCH,NEDD4

DEGRON score: 0.9939

ASA_SCORE: 76.625

COIL: 0.9035

CONS_SCORE: 0.4605

DSS_SCORE: 0.3952

HELIX: 0.0702

FCONS_SCORE: 1.122

RIG_SCORE: 0.7919

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q707R	TCGA-AX-A05Z	UCEC	TCGA	PPMY	ITCH	0.3056
p.Q707R	DO40884	UCEC	ICGC	PPMY	ITCH	0.3056
p.R699C	TCGA-AX-A1C9	UCEC	TCGA	PPMY	ITCH	0.2222
p.R699C	DO43098	UCEC	ICGC	PPMY	ITCH	0.2222
p.R699C	SIDM00680	Colorectal Carcinoma	GDSC	PPMY	ITCH	0.2222
p.R699C	ACH-000957	Colon/Colorectal Cancer	CCLE	PPMY	ITCH	0.2222
p.R699C	LS-180	large_intestine	COSMIC	PPMY	ITCH	0.2222
p.Y706C	TCGA-D8-A140	BRCA	TCGA	PPMY	ITCH	0.7087
p.Y706C	DO2204	BRCA	ICGC	PPMY	ITCH	0.7087
p.N715K	TCGA-EO-A22X	UCEC	TCGA	PPMY	ITCH	0.0833
p.N715K	DO43907	UCEC	ICGC	PPMY	ITCH	0.0833
p.R708Q	TCGA-EW-A1OV	BRCA	TCGA	PPMY	ITCH	0.2778
p.R708Q	DO1550	BRCA	ICGC	PPMY	ITCH	0.2778
p.R699H	TCGA-XK-AAIW	PRAD	TCGA	PPMY	ITCH	0.2222
p.R699H	DO51407	PRAD	ICGC	PPMY	ITCH	0.2222
p.P693S	DO224805	BRCA	ICGC	PPMY	ITCH	0.0556
p.P693S	DO52546	BRCA	ICGC	PPMY	ITCH	0.0556
p.R702H	DO228138	PBCA	ICGC	PPMY	ITCH	0.3056
p.R702H	SIDM00213	Thyroid Gland Carcinoma	GDSC	PPMY	ITCH	0.3056
p.R702H	ACH-000903	Thyroid Cancer	CCLE	PPMY	ITCH	0.3056
p.R702H	FTC-133	thyroid	COSMIC	PPMY	ITCH	0.3056
p.R702C	SIDM00373	Endometrial Carcinoma	GDSC	PPMY	ITCH	0.3056
p.R702C	ACH-000974	Endometrial/Uterine Cancer	CCLE	PPMY	ITCH	0.3056
p.P704A	SIDM00845	Burkitt's Lymphoma	GDSC	PPMY	ITCH	0.7503
p.P704A	SIDM00035	Thyroid Gland Carcinoma	GDSC	PPMY	ITCH	0.7503
p.P704A	SIDM00461	Acute Myeloid Leukemia	GDSC	PPMY	ITCH	0.7503
p.P704A	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PPMY	ITCH	0.7503
p.P704A	SIDM01519	Head and Neck Carcinoma	GDSC	PPMY	ITCH	0.7503
p.P704A	ACH-000037	Sarcoma	CCLE	PPMY	ITCH	0.7503
p.P704A	ACH-000786	Lymphoma	CCLE	PPMY	ITCH	0.7503
p.P704A	S-117	soft_tissue	COSMIC	PPMY	ITCH	0.7503
p.P704A	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	PPMY	ITCH	0.7503
p.P704A	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	PPMY	ITCH	0.7503
p.P704A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PPMY	ITCH	0.7503
p.M705V	SIDM01525	Acute Myeloid Leukemia	GDSC	PPMY	ITCH	0.6097
p.M705V	ACH-000557	Leukemia	CCLE	PPMY	ITCH	0.6097

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13521	Secretogranin-2	ITCH	167:170	PPMY	ITCH,NEDD4	0.519	More...
Q01954	Zinc finger protein basonuclin-1	ITCH	74:77	PPMY	ITCH,NEDD4	0.8829	More...
Q86VH2	Kinesin-like protein KIF27	ITCH	608:611	PPMY	ITCH,NEDD4	0.6139	More...
Q86WA8	Lon protease homolog 2, peroxisomal	ITCH	640:643	PPMY	ITCH,NEDD4	0.768	More...
Q96LT9	RNA-binding region-containing protein 3	ITCH	206:209	PPMY	ITCH,NEDD4	0.9928	More...
Q9HBD1	Roquin-2	ITCH	703:706	PPMY	ITCH,NEDD4	0.9939	More...
Q9HCF6	Transient receptor potential cation channel subfamily M member 3	ITCH	1515:1518	PPMY	ITCH,NEDD4	0.8817	More...
Q9NRJ4	Tubby-related protein 4	ITCH	1241:1244	PPMY	ITCH,NEDD4	0.769	More...
O15255	CAAX box protein 1	ITCH	94:97	PPMY	ITCH,NEDD4	0.956	More...
Q8NA69	Testis-expressed protein 45	ITCH	496:499	PPMY	ITCH,NEDD4	0.9984	More...
Q9P281	BAH and coiled-coil domain-containing protein 1	ITCH	901:904	PPMY	ITCH,NEDD4	0.9559	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPMY

Degron related mutations and impact score

Drug responses associated with RC3H2 mutations

All proteins holding degron of PPMY