DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
PPMY
Uniprot ID:
Q96LT9
Source protein:
RNA-binding region-containing protein 3
Source gene:
RNPC3
Class:
ITCH
Location:
206:209
E3 ligase:
ITCH,NEDD4
DEGRON score:
0.9928
ASA_SCORE:
80.5
COIL:
0.866
CONS_SCORE:
0.4095
DSS_SCORE:
0.4292
HELIX:
0.0888
FCONS_SCORE:
1.0922
RIG_SCORE:
0.6752
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A204V
TCGA-D1-A16G
UCEC
TCGA
PPMY
ITCH
0.2778
p.A204V
DO43074
UCEC
ICGC
PPMY
ITCH
0.2778
p.A204T
TCGA-EY-A5W2
UCEC
TCGA
PPMY
ITCH
0.2778
p.A204T
DO48177
UCEC
ICGC
PPMY
ITCH
0.2778
p.A204T
ACH-000895
Colon/Colorectal Cancer
CCLE
PPMY
ITCH
0.2778
p.P218S
DO8360
COAD
ICGC
PPMY
ITCH
0.0833
p.P201L
DO227987
COCA
ICGC
PPMY
ITCH
0.1944
p.A217E
DO229253
THCA
ICGC
PPMY
ITCH
0.1111
p.A217V
DO229240
THCA
ICGC
PPMY
ITCH
0.1111
Drug responses associated with RNPC3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PPMY
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P13521
Secretogranin-2
ITCH
167:170
PPMY
ITCH,NEDD4
0.519
More...
Q01954
Zinc finger protein basonuclin-1
ITCH
74:77
PPMY
ITCH,NEDD4
0.8829
More...
Q86VH2
Kinesin-like protein KIF27
ITCH
608:611
PPMY
ITCH,NEDD4
0.6139
More...
Q86WA8
Lon protease homolog 2, peroxisomal
ITCH
640:643
PPMY
ITCH,NEDD4
0.768
More...
Q96LT9
RNA-binding region-containing protein 3
ITCH
206:209
PPMY
ITCH,NEDD4
0.9928
More...
Q9HBD1
Roquin-2
ITCH
703:706
PPMY
ITCH,NEDD4
0.9939
More...
Q9HCF6
Transient receptor potential cation channel subfamily M member 3
ITCH
1515:1518
PPMY
ITCH,NEDD4
0.8817
More...
Q9NRJ4
Tubby-related protein 4
ITCH
1241:1244
PPMY
ITCH,NEDD4
0.769
More...
O15255
CAAX box protein 1
ITCH
94:97
PPMY
ITCH,NEDD4
0.956
More...
Q8NA69
Testis-expressed protein 45
ITCH
496:499
PPMY
ITCH,NEDD4
0.9984
More...
Q9P281
BAH and coiled-coil domain-containing protein 1
ITCH
901:904
PPMY
ITCH,NEDD4
0.9559
More...